Did we get dietary saturated fats all wrong? The #HADLmodel provides a new understanding and an opportunity to get it right. THREAD👇👇👇
@simondankel @kariannesve

Increased dietary saturated fatty acids lead to increased cholesterol in lipoproteins, but we don’t know why. Enter the #HADLmodel, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that ensure optimal cell membrane fluidity and cell function.

We propose that circulating lipoproteins enable appropriate redistribution of cholesterol molecules between specific cells and tissues, to accomodate changes in dietary fatty acid supply, due to our omnivore nature and variable intake of fatty acids. #HADLmodel

Our #HADLmodel implies that circulating levels of LDL change for protective, not for pathological reasons; an SFA-induced raise in LDL cholesterol in healthy individuals is a normal response, while a lack of this needed response may reflect a deeper pathology in lipid handling.

Circulating lipoproteins may change for pathological reasons, when regulatory mechanisms become disrupted by pathogenic processes related e.g. to inflammatory processes. Diverging lipoprotein responses in healthy versus metabolically unhealthy individuals support this view.

What is carbon capture? And how does it work?

While carbon capture is regularly discussed in the media, no one really ever explains what it is.

Below is a quick thread discussing the technology behind traditional carbon capture 👇

Carbon capture is broadly the "capture" of CO2 emissions from a power plant or other type of industrial facility.

Technology is connected to the "tailpipes" of these facilities and is used to remove CO2 from the plant exhaust.

Once the CO2 is removed from the plant exhaust, it is typically pressurized and sent under ground for permanent storage.

This step is called "sequestration" and is why experts often talks about "carbon capture and sequestration" or "CCS".

So how do you "capture" the CO2 molecules from exhaust?

Currently, one of the most economic forms of carbon capture is called "amine-based" capture.

An "amine" is a special liquid chemical which selectively grabs on to CO2 molecules.

To get the amine to grab on to the CO2, the amine is put into the top of a large column, while the exhaust is put into the bottom of the column.

The exhaust bubbles up through the column, and the amine drips down.

The liquid amine and gas exhaust mix in the column.

1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.

The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.

2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.

3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.

4/ The stretching of the septum builds up an elastic tension in the septum, which is released as recoil, when tension declines in the lateral wall, showing a post systolic shortening in the septum which is due to elasticity.

And since today is International Day of Women and Girls in Science, let's highlight a few of them - just a few women among thousands of others who helped shape the world we live in today.

Thread.

Dorothy Hodgkin discovered the structure of insulin after 36 years of work.

"I was captured for life by chemistry and by crystals."

Sophia Jex-Blake fought for women's rights to study medicine. She was involved in founding two medical schools for women.

"It seemed discreditable to Great Britain that all her daughters who desired a University education should be driven abroad to seek it."

Alice Augusta Ball developed the "Ball Method", the most effective treatment for leprosy during the early 20th century. She was 23.

Ada Lovelace is regarded as the first to recognize the full potential of computers and as one of the first computer programmers.

“That brain of mine is something more than merely mortal; as time will show.”

11 BIG IDEAS OF PHYSICS

via @BlasMoros of @LTCWRK

(Thread 👇)

1. Galilean Relativity

We can never fully grasp, define, or understand a system we are part of.

“Distance provides perspective” and wisdom in life is often about perspective.

2. The Laws of Thermodynamics

The study of the large-scale behavior of systems exchanging work and heat with connected systems or their environment.

- The Transitive Law

- The Law of Conservation

- The “Contrast Advantage” Law

- The “Absolute Zero” Law

3. Newton’s Laws of Motion

Describe how objects in the world move and react to forces.

- The Inertia Law: An object at rest, stays at rest

- Force = Mass * Acceleration (F = ma)

- The Law of Reciprocity: For every action there is an equal and opposite reaction

4. Complexity

A complex system exhibits emergent behavior due to the collective interaction of many individual agents according to simple rules.

Complex systems are sensitive to original conditions, influenced by feedback loops, and buffeted by random outside variables.

https://t.co/xvP6tVlIaE
Quite a surprise. Ferguson isn’t qualified to comment on such things. He lacks understanding of basic biological concepts, partly explaining why his predictions are often so extreme.

That said, I’ll take him as an ally. It’s clear we’re already at herd immunity. How can I be sure? London had a huge peak of excess deaths in spring. The timing of peak deaths showed clearly that the pandemic was self-limiting. Recall much debate about whether the interval...

...between lockdown & peak deaths was long enough for lockdown to have been the cause of reducing deaths? The answer was “no”. But it was close & I can understand people thinking “well, it’s close, so perhaps it was lockdown that did it?”, thereby establishing a foundational...

...myth favoured by those who genuinely believe lockdown saves lives (it clearly doesn’t).
I’ll get to London & here immunity. But those wavering about the evidence about lockdown in spring really will benefit from cogitating on this graph.

In blue are the 30 trusts with the earliest date of peak deaths in spring. In red, the 30 with the latest peak deaths. For me, this is proof that national lockdown, which began Mar 23, played no role whatsoever in turning the pandemic. You’ll see some areas had peak daily...

I think I've permanently confused KiCAD
it's reminding me that I need to connect this capacitor to Nothing

attach this end to ground, this end to +5v, and this end to THE VOID

I accidentally made all the capacitors gigantic and they won't fit anymore

halp

gonna design an ISA card using some of these

it's gonna be tricky to fit in the case

that's from this

Here's more on the new mitigation scenario for 1.5C. How does it work? What would society look like? Are we willing to do what's required to stop climate breakdown? See thread.

1. Most models assume we need to keep growing the economy indefinitely. The problem is this makes it impossible to transition to zero emissions quickly enough; so they speculate on geoengineering and negative-emissions technologies to save us. Scientists reject this as too risky.

2. By contrast, this scenario proposes that high-income countries don't *need* more growth, and can scale down unnecessary production and consumption. This reduces energy demand (from 140 EJ in 2020 to 40 EJ in 2050), and enables a rapid transition to renewable energy.

3. What does it require? In the global North (Annex 1 countries)
•a shift from private cars to public transportation
•reduction in flights
•smaller average house size

Meanwhile, consumption in the global South (non-Annex 1 countries) rises to converge.

4. Significant reduction of aggregate material use. How? Longer product lifespans; regionalization of production and consumption; ban on advertising; a shift in taxes from labour to resources. All of this allows us to reduce ground freight, which cuts energy use.

(THREAD CONTINUED)
As mentioned in the above videos human cloning has been confirmed and many of the elites you are now seeing are in fact clones or doubles standing in for themselves. The reason for these clones is because humanity has not yet awakened enough to handle knowing

all the crimes these sick disgusting Deep State Freemasonic Illuminati Cabal Globalist Satanists are truly involved in. The majority of society would literally go mentally insane if they learned all of this information at once.

The Nature versus Nurture is a debate about scientific doctrine. It is a debate about the correct way of explanation for cognition.

The Representation versus Non-Representation shares the same debate. It is also about the correct way of explanation for cognition.

It is also the difference between thinking in nouns versus thinking in verbs. Nature and Representation have deep roots in Western thinking. It is a functionalist and reductionist way of thinking that meets its limits when analyzing complex adaptive systems.

It is perhaps due to this Western bias that concepts from the study of complex systems have had little traction in modern society. It is of course, more than a Western bias, but a human bias to seek out simple causal explanations of this world.

But the world is complex and messy. Spiral dynamics which is an evolutionary model of individuals and society explains how models of the world shape ourselves and our civilization.

In physics, energy is that which is causally invariant or symmetric with respect to time. Said differently, energy is never created or destroyed, it is conserved in the universe.

Now there is a question about information. Is information causally invariant? Does information remain the same with respect to time? To understand this, let's first understand what energy is, then attempt to understand what information is.

The strange thing about energy is that it is this universal currency that seems to be interchangeable between the different forces in nature (i.e. electromagnetic, strong, weak and gravity). It is that thing that makes change possible.

Now let's assume that the universe is computational in nature. That is, anything we see in nature is a consequence of computation. That is, there is computation underneath the physics that is driving the universe to change.

What does it mean then that information is conserved in this computational universe? Also, how is energy conservation related to information conservation?

Why English as the Universal Language of Science Is a Problem for Research

Where do most of the researchers and inventors around the world appear today? What is their mother tongue?
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The obstacle to many researches in our country is that many of the documents and research articles that they need to do research are available in English only 80-90%.

Can't anyone read and understand research articles so easily? Why is that?
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Today most scientific papers are published in English. What is lost when other languages ​​leave?

Plagiarism in research articles Should not be. What is Plagiarism?
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Plagiarism is the representation of another author's language, thoughts, ideas, or expressions as one's own original work.

In educational contexts, there are differing definitions of plagiarism depending on the institution.
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plagiarism is the representation of another author's language, thoughts, ideas, or expressions as one's own original work.

In educational contexts, there are differing definitions of plagiarism depending on the institution.
5/8