Solara Active Pharma Science con call was today at 3:30 PM.

@Gautam__Baid @unseenvalue @drprashantmish6 @rdkriplani

Here are the key takeaways of the call. 👇🧵

Business Updates:

• Speed of filing products has been increased. Filed 5 new DMFs – 3 in US and 2 in EU
• Currently ramping up the facility in VIZAG with strong customer attraction, and will be commercialized as planned in Q3
• VIZAG EBIDTA growth guidance changed to 40%+ YoY

• Growth Driver: Broad based growth in other products and Vizag.

• PLI: Company has filed Mysore for PLI scheme for 1 molecule.

• Technology: Company is about to complete its 2 out of 3 technology, which will enhance efficiency for Solara.

Demand in some of sectors is moderated:
• Mgmt expected moderation in demand, hence company has taken necessary steps for those products.

Gross Margins:
• It was down a bit due to product mix however.

Fiscal 2022:
• Solara has grown in regulated market space.
• Vizag will kick in. CRAMS will support tailwind.
• Most of the CRAMS is commercial API.

• Most of the product is expected to be stable both in term of demand and price in the coming few quarter

1) Science denial is destroying our societies, our civilization. Various vested interests, usually right wing ideologues find various scientific facts and information contrary to their agenda, so through propaganda they are orchestrating the public into denying this science.

2) We are seeing this with regard to the COVID virus, where a range of denial is being promoted, ranging from absolute denial the virus exists, to different levels of denial, such as only some people are vulnerable to the virus, to facilitate business as usual.

3) For a long time, to promote business as usual, vested interests have been promoting the denial of the climate and ecological crisis through propaganda. The aim being to create a large enough body of public denial to prevent action which can change anything.

4) We have seen similar patterns over a long time, such as when tobacco companies promoted denial of the emerging scientific evidence of how harmful and addictive tobacco smoking was. This further denial uses exactly the same methods.

5) Understandably, the public can't be educated about everything and have to rely on experts to inform them of concerns about threats to public safety. Malicious vested interests take advantage of this by using pseudo-experts to misinform the public.

Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval

⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.

Fellow academics, when are we going to start fixing our urgent structural problems that strain family bonds and present ongoing barriers to diversifying our educational and scientific leadership? You wonder, what the heck is this guy talking about?
1/n

We’re all very familiar what I am talking about, actually: the impossibility for most academics in the life sciences to do their jobs in a reaonable amount of time, due to more and more demands on writing grants, and to a lesser degree, papers.
2/n

As of yesterday I hadn’t intended to write about this subject, but was wondering as I finished a Saturday of straight work, what happened to all my time? Why has WFH not reduced my pile of tasks to do? Instead why is my to-do list growing bigger and bigger?
3/n

I decided to figure out how much time our jobs actually require. I estimated per year (m=month, w=week, d=day, h=hour):
Teaching: 20h/w x 20w = 400h
Meetings of all sorts: 10h/w x 48w= 480h
Replying to email: 2h/d x 365d = 730h
Attending and giving talks: 2h/w x 50w = 100h
4/n

Papers: If each person needs 2 papers during a 5y stint, and you run a 7.5-person lab, then you need 7.5 papers per 2.5y = 3 papers/y. Throw in a review and it’s 4 papers. If you need 15d at 8h/d per paper, that’s 480h writing papers.
5/n

Today, we are bringing other exciting results involving black holes and AI. We released a new paper:

"Black Hole Weather Forecasting with Deep Learning: A Pilot Study"

Work by Roberta Duarte (@import_robs), Rodrigo Nemmen (@nemmen) and João Paulo Navarro (from @NVIDIABrasil).

The authors used deep learning to simulate the dynamics of gas accreting onto a black hole, i.e., black hole weather forecasting.

They trained the model (U-Net) with frames from numerical solutions of the hydrodynamical equations.

Numerical simulations are time-consuming. A simple simulation can take as long as 7 days to finish. If we go with more complex simulations, this time may increase.

We want to investigate if deep learning can be a new method to simulate accurately in less time!

In the paper, they discussed two examples:

1- The model simulating only one system after learning only from this system
2- The model simulating an unseen system after training with several systems with different initial conditions

In the first example, they trained the model with a single system and analyzed how the model simulates by iterative predictions.

The result is that the model can simulate up to 8e4 gravitational time accurately with a speed-up of 30000x faster!

It is astonishing that most of cognitive science ignores an obvious reality. That there are two kinds of humans.

Tomasello has a very credible hypothesis that what distinguishes humans from the great apes is the inclination towards shared intentional behavior. What is innate is the disposition and like personalities, it is what defines our cognition as we grow.

If cognitive preference is so critical in cognitive development then why is it that we seem to have completely ignored the difference in cognitive preferences between men and women?

Humans are that species of primates that wandered out into the savannah. The savannah is different enough from a dense jungle to exert the evolutionary pressures that encourage the development of planning and forecasting skills.

Furthermore, human infants required a disproportional amount of effort to rear. This meant the specialization of roles between women who were responsible for rearing offspring and men who were responsible for bringing home the bacon. Failure in either implied death.

I recently submitted my PhD dissertation titled "Illiberalism Beyond Borders. Dissecting Russian and Turkish External Influence in Bosnia and Georgia" at @FU_Berlin. Interested in what I found? Read this thread ⬇️

To begin with, I hypothesise that illiberal external influence (IEX) is more likely to contribute to the contestation of #democracy in a given polity when it appears in the context of a favorable domestic environment and the absence of liberal external counterpressure.

I particularly scrutinise the role of domestic elites in facilitating/obstructing IEX, based on findings by J. Tolstrup, @otansey, R. Vanderhill et al. I also look at how liberal ext. counterpressure can help prevent a major contribution of IEX to the contestation of #democracy.

Between 2016-2018, I conducted 95 interviews in #Tbilisi, #Moscow, #Sarajevo & #BanjaLuka (thx to all interlocutors!). Given the increasingly unfree environment in Turkey, I didn't dare to make a trip to Ankara, but talked to local experts about Turkish IEX in BiH & Georgia.

In #Bosnia, #Ankara has engaged in illiberal sponsorship of the Party of Democratic Action for many years. However, in both Bosnia and #Georgia, Ankara mostly exerted illiberal external influence after the 2016 coup attempt, following which it exerted pressure on the rule of law.

Thread for folks looking for roles in biopharma VC. Nearly every week I speak to someone who wants to get into biopharma VC. One high-level theme: even for entry roles, you *generally* need to check the box “understands science” as well as the box “can do basic financial... 1/9

Azar just released a delusional, alternative history of Covid testing in the US. I’m mad because our testing failures allowed this outbreak to blow-up. We can’t fix our system if we ignore where it is broken. I suspect @PublicHealth agrees.

My fact-check on remarks @HHSGov 🧵

“It is indisputable that the United States has built the most extensive testing system and strategy of any major country,” says Azar.

False. Several countries have had percent positivity ~1% whereas US has never been below 5% and is >10% today. Refs KCDC & USA @JohnsHopkins

"The federal government got out of the way of test development in safe and sensible ways,” says Azar.

False. In Feb, CDC & FDA blocked labs from testing as the disease spread exponentially. I broke this story👇🏼& wrote more like it as the year wore on.

Azar defends questions about why the CDC refused an early German test vetted & distributed by WHO, by saying it was ‘unapproved’ & beneath us.

False. Top US researchers in my stories vetted several tests as early as Feb,& found that the one recommended by WHO was ideal.

Azar refuses to concede that other countries handled Covid better. He attributes Koreas success to less travel, invasiveness & private sector.

False. Korea's gov't marshaled the private sector & tracing success was largely from hiring tons of tracers.

Extremely excited today to reveal the first of two great works (magnus opera?), just posted on bioarxiv, applying regulatory network analysis techniques to PDAC expression data to dissect the underlying biology of the disease. Tweetorial time! 1/

Eight years ago I launched an enduring collaboration with Andrea Califano @ColumbiaCancer to apply his regulatory network analysis techniques to #pancreaticcancer. So many amazing scientists have contributed to this work: @paslaise @hc_maurer @AlvaroCurielGa1 @ElyadaEla 2/

What is “regulatory network analysis”? At it's heart, it's a way of extracting more useful information from expression profiles. A fundamental flaw of differential gene expression (DGE) analysis is the assumption that each gene is independent. Biologist KNOW this is not true! 3/

DGE treats all ~25K detectable genes as SEPARATE variables, performs 25K T-tests, and then slaps on a multiple hypothesis correction to make the statisticians less dyspeptic. There is no consideration of the relationships between genes! 4/

Yet we KNOW genes are co-regulated in SETS by transcription factors and other REGULATORY FACTORS. Biologist: “p21 is a target of p53”. DGE: “Shhhh”. These relationships are completely ignored by expression analysis. THIS IS A TRAVESTY! 5/

All Biological life on earth is possible because of a discrete digital mechanism of preservation and replication.

The mechanism of signaling between the superorganism we know of as bacteria and its ongoing war against viruses is through a digital mechanism.

The source of innovation in biology is in this milieu of microbiome and viromes that are ubiquitous in every complex multicellular organism on earth. Humans are walking ecologies and cannot survive stripped of these ecologies.

We can picture this as a cloud of digital interaction that surrounds all of us.

The cells of multicellular creatures however do not communicate in the same way as bacteria. The DNA of mammals are sequestered from daily activity so as to prevent wear and tear.

What is MKULTRA? - THREAD 🔥🔥🔥🔥🔥🔥🔥
CIA MKULTRA / Mind Control

Project MKUltra—sometimes referred to as the CIA’s mind control program—was the code name given to an illegal program of experiments on human subjects, designed and undertaken by the United States Central

So where are we at with this virus people?

HOW TO STAY YOUNG:

Starve-destroy-recycle-eat-build-eat-build-starve...

The human ecosystem (our internal environment) has the same processes as the environmental ecosystem. Destruction & Reconstruction is a universal process. This is how we stay young.

We should take our cue from the senolytic processes of nature. A coppiced Hazel tree is near immortal.

Too much destruction (chronic calorie restriction) and too much growth (hyperfunction/ constant eating) are both bad and lead to derangement.

'A single bout of resistance training induced rapid clearance of senescent cells in muscle' h/t @Mangan150

"Conc: Rapid senescent cell clearance of human skeletal muscle during resistance exercise seems to associate with enhanced in situ phagocytosis. High protein availability accelerates resolution of muscle inflammation and promotes muscle increment after training" h/t @SPKP1124

As promised, a thread explaining our newest BioRxiv paper, where we’ve discovered that C. elegans can transfer memories of pathogen avoidance to naïve individuals.

What if one worm could tell another that it has learned it is infected with a pathogen, and warn others? The idea of memory transfer has a checkered past, since the earliest reports of memory transfer in planaria.

We- @rebeccasmoore1 and Rachel Kaletsky, primarily- have been studying how C. elegans learns to avoid Pseudomonas after becoming sick. We previously found that they eat bacterial small RNAs, and one small RNA (P11) that is only around when the bacteria are pathogenic triggers...

...an avoidance response that happens not only in mothers, but is remembered by four generations of their progeny. We know that this process involves uptake and Dicer processing of small RNAs in the intestine, germline amplification, piRNAs,

and downregulation of a neuronal gene, maco-1, in the ASI neuron.