11 BIG IDEAS OF PHYSICS

via @BlasMoros of @LTCWRK

(Thread 👇)

In a number of Sunday papers:
Scientific advisers said it was “hard to see” when the restrictions would end as new variants continued to emerge, delivering a potentially devastating blow to the travel industry. The prime minister said that after progress with vaccinations...

...”what we don’t want to see is all that work undone by the arrival of a new variant that is vaccine-busting”.
The idea is planted in people’s mind that this virus is mutating in such a way as to evade prior immunity. This is completely unfounded, certainly as regards immunity..

...gained naturally, after repelling the virus (which well around 99.9% of the population do, fewer, obviously in the very elderly & already ill, more in those younger & well). It’s important to appreciate that upon infection, the human immune system cuts up an infectious...

...agent into short pieces. Each of these short pieces of protein are presented to other cells in the immune system, like an identity parade. Our cells have a truly astonishing range of abilities to recognise different protein structures, and there will be some which recognise...

...each of the pieces of the invader. The cells which recognise a piece are instructed to multiply selectively so that, after a few days to a couple of weeks, our bodies contain large numbers of virus piece specific cells. These have a range of functions. Some make antibodies...

With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

THREAD
The world is littered with hacks and quick fixes.

Magic routines, butter in our coffee, special supplements, exotic foods. All promising to transform our lives.

Nearly all of it is BS. Here are 12 science-backed "hacks" that actually work.

Read a Book.

An expert in their field has taken their vast knowledge and distilled it to what's most important. Writing forces you to make difficult decisions on what's important and what's not. Writing demands clarity. You're getting an expert's lifetime of work for $15.

Talk to people who know more.

The best way to "hack" knowledge? Have a conversation with those who are informed. They've done the hard part of figuring out of sorting through the mess of information AND making sense of it. Having a conversation brings clarity for application.

Show up, no matter what.

Day after day. Sit down to write. Get out to exercise. Whatever the task you're trying to master, just keep showing up.

If you show up enough, you'll get better.

Sleep.

Just getting your 8+ hours has enormous benefits from the psychological to physical. Sleep is when your body restores & grows with its highest output of growth hormones, & when your mind processes and coalesces information. Translating knowledge from superficial to deep