BC SCIENCE

$Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193$

Billy Bostickson 🏴👁&👁 🆓
@BillyBostickson 5 years, 4 months ago 1068 views

a6yrWK5dqg

https://t.co/e3RBxj0ly3

1. Monkey Outrage!
The worst treatment was kept for the monkeys. The macaques breed of monkeys are small, relatively light primates, which are often used for animal experiments at LPT. \u2018They are kept in cramped conditions in small cages. https://t.co/6D0yisjd9B
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) August 17, 2020

https://t.co/cJlCMqyP2v

11. Max Planck Monkey Photos (2) pic.twitter.com/0yE9D6iswp
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) August 17, 2020

https://t.co/5n5TK67iKB

https://t.co/r5JIAWB9Oq

More from Billy Bostickson 🏴👁&👁 🆓

$Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193$

Billy Bostickson 🏴👁&👁 ...
@BillyBostickson

!. Simple Sabotage Tips
Unhappy with Everyday Life?
Frothing at the Mouth against oppressive bureaucracy?
Sick of petty tyrants and tin pot dictators?
Tormented by intrusive modern technology?
Feel like "sticking it to the man"?

2. The following is taken from sections 11,12 of the OSS's Simple Sabotage Field Manual, a 1944 document that has been declassified. The OSS became the CIA after WWII. The full document is

3. (a) Organizations and Conferences
Insist on doing everything through "channels." Never permit short-cuts to be taken in order to, expedite decisions.

4. Make "speeches." Talk as frequently as possible and at great length. Illustrate your "points" by long anecdotes and accounts of personal experiences.
Never hesitate to make a few appropriate "patriotic" comments.

5. When possible, refer all matters to committees, for "further study & consideration"
make the committees as large as possible - never less than 5
- Bring up irrelevant issues as frequently as possible
- Haggle over precise wordings of communications, minutes, resolutions

$Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193$

Billy Bostickson 🏴👁&👁 ...
@BillyBostickson

Tip from the Monkey
Pangolins, September 2019 and PLA are the key to this mystery
Stay Tuned!

1. Yang

Meet Yang Ruifu, CCP's biological weapons expert https://t.co/JjB9TLEO95 via @Gnews202064
Interesting expose of China's top bioweapons expert who oversaw fake pangolin research
Paper 1: https://t.co/TrXESKLYmJ
Paper 2:https://t.co/9LSJTNCn3l
Pangolinhttps://t.co/2FUAzWyOcv pic.twitter.com/I2QMXgnkBJ
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) October 11, 2020

2. A jacobin capuchin dangling a flagellin pangolin on a javelin while playing a mandolin and strangling a mannequin on a paladin's palanquin, said Saladin
More to come tomorrow!

3. Yigang Tong
https://t.co/CYtqYorhzH
Archived: https://t.co/ncz5ruwE2W

4. YT Interview
Some bats & pangolins carry viruses related with SARS-CoV-2, found in SE Asia and in Yunnan, & the pangolins carrying SARS-CoV-2 related viruses were smuggled from SE Asia, so there is a possibility that SARS-CoV-2 were coming from

$Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193$

Billy Bostickson 🏴👁&👁 ...
@BillyBostickson

1. WIV Research groups (archived pages) for Reference
dsRNA viruses molecular biology

https://t.co/lwrQoo6ygG

2. Emerging Viruses Group

https://t.co/ND56gVGOAn

3. Structural Biology of Viral Genome Replication
https://t.co/wUqc0YIP3X

4. Molecular Biology of hepatitis Viruses & Gene Therapy
https://t.co/snBbxkhNsC

5. Insect Virus Genetic Engineering Lab
https://t.co/S68mVOA2Ob

$Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193$

Billy Bostickson 🏴👁&👁 ...
@BillyBostickson

November 3 - 9, 2019 -Wuhan Institute of Virology
International Training Course on Biosafety Laboratory Management and Technology
1. Daniel Feakes, head of UN Biological Weapons Convention implementation support agency
2. René Courcol, quality control system expert, France's BSL

List of Lecturers with short bios at
November 3 - 9, WIV Training Course: https://t.co/Bsd9yO40JP
YUAN Zhiming Professor, Wuhan Institute of Virology, CAS (Deputy Director)
SONG Donglin, Professor, Wuhan Institute of Virology, CAS ( Deputy Director of Wuhan BSL-4 Laboratory.)

Dr. TONG Xiao Senior Engineer at WIV (Molecular Virology & (HIV) infection, mechanical & vaccine immunology) On-site Manager & Chief engineer for WIV BSL-4 Lab construction, maintenance & biosafety equipment R&D.

Zhengli Shi, Director of WIV Center for Emerging Infectious Diseases, now in charge of scientific activity in BSL3 & BSL4. Viral pathogen discovery through sequencing techniques, wildlife-borne viral pathogens, particularly bat-borne viruses since 2004.

DENG Fei, Principle Investigator in Research Group on Viruses Resources & Biotechnology in WIV, also Director of Microorganisms & Viruses Resource Center.
Graduate of ECUST, went to Great Lakes Forestry Center, Canada in 2001 & Wageningen University, NL to study baculovirus.

$Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193$

Billy Bostickson 🏴👁&👁 ...
@BillyBostickson

1. Finally!
I found the original H1N1-H5N1 "novel" viruses emails! Yes!
https://t.co/MoPgxYJIEv
Kawaoka Busted!

2. Kawaoka Busted!
More email evidence here:
More Smoking Gun Emails From Kobe University Virologist Teridah Ernala Ginting
Acts Of Espionage Against Indonesia by Akiko Makino and Others From Kobe University's "Secret"

3. NAMRU 2 Indonesia
(where Kawaoka organised theft of viruses)
(Now moved to Phnom Penh)
https://t.co/snRmicOIGN
History:
https://t.co/vEjltSDTOj
Perspectives on the DOD Global Emerging Infections Surveillance System:
GEIS at NAMRU 2, Indonesia (PDF)
https://t.co/SKm22oqBD4

4. NAMRU 2 Indonesia Controversy (2008)
Indonesia Suspends US NAMRU Lab Operations
https://t.co/kLW3zhiDVz
Supari On NAMRU-2
https://t.co/0wPbF4TpTJ
Indonesian Lawmakers Call For NAMRU-2 Probe
https://t.co/S4zZ4TaksW
NAMRU-2 Debate Turns

5. NAMRU Indonesia Controversy Part 2
U.S. insists on immunity for all Namru-2 laboratory staff
https://t.co/KelkEqJQTn
A "fact sheet" on NAMRU-2
https://t.co/Z08aLEDIJ4
US Embassy Half Truths:
https://t.co/b0nP0aVIwV
Indonesia: More attacks on

More from Science

Marina Amaral
@marinamaral2

And since today is International Day of Women and Girls in Science, let's highlight a few of them - just a few women among thousands of others who helped shape the world we live in today.

Thread.

Dorothy Hodgkin discovered the structure of insulin after 36 years of work.

"I was captured for life by chemistry and by crystals."

Sophia Jex-Blake fought for women's rights to study medicine. She was involved in founding two medical schools for women.

"It seemed discreditable to Great Britain that all her daughters who desired a University education should be driven abroad to seek it."

Alice Augusta Ball developed the "Ball Method", the most effective treatment for leprosy during the early 20th century. She was 23.

Ada Lovelace is regarded as the first to recognize the full potential of computers and as one of the first computer programmers.

“That brain of mine is something more than merely mortal; as time will show.”

Sri Krishna
@tellkrish

With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

Katie Mack
@AstroKatie

Light travels at about 1 foot per nanosecond.

Hold your hand up 12 inches from your face: you’re seeing your hand as it was a nanosecond ago. Everything you look at is, to one degree or another, in the past. The farther away in space, the more ancient in time.

You can’t see the Sun as it is now, but you can see it as it was about 8 minutes ago. You can’t see Alpha Centauri now, but you can see it 4.4 years ago. You can see the Andromeda Galaxy as it was 2.5 million years in the past. And so on.

With powerful telescopes, we can see galaxies whose light has been traveling to us for more than 13 billion years. We see them shining in a universe that’s still young, where gravity has just begun to pull matter together into stars and galaxies.

We can see something even more distant, and more ancient, than the first galaxies. If we peer out far enough, in between the galaxies, we can see parts of the Universe that are so far away, it has taken the light from that distance almost the entire age of the cosmos to reach us.

$Asbj\xf8rn St\xf8ylen$

Asbjørn Støylen
@strain_rate

1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.

The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.

2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.

3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.

4/ The stretching of the septum builds up an elastic tension in the septum, which is released as recoil, when tension declines in the lateral wall, showing a post systolic shortening in the septum which is due to elasticity.

Michael Wara
@MichaelWWara

Ever since @JesseJenkins and colleagues work on a zero carbon US and this work by @DrChrisClack and colleagues on incorporating DER, I've been having the following set of thoughts about how to reduce the risk of failure in a US clean energy buildout. Bottom line is much more DER.

Rooftop solar can play a key role in a transition to 100% renewable energy - and it can help American's pocketbooks #GoSolar https://t.co/6p9jb62EGW
— Environment America (@EnvAm) January 14, 2021

Typically, when we see zero-carbon electricity coupled to electrification of transport and buildings, implicitly standing behind that is totally unprecedented buildout of the transmission system. The team from Princeton's modeling work has this in spades for example.

But that, more even than the new generation required, runs straight into a thicket/woodchipper of environmental laws and public objections that currently (and for the last 50y) limit new transmission in the US. We built most transmission prior to the advent of environmental law.

So what these studies are really (implicitly) saying is that NEPA, CEQA, ESA, §404 permitting, eminent domain law, etc, - and the public and democratic objections that drive them - will have to change in order to accommodate the necessary transmission buildout.

I live in a D supermajority state that has, for at least the last 20 years, been in the midst of a housing crisis that creates punishing impacts for people's lives in the here-and-now and is arguably mostly caused by the same issues that create the transmission bottlenecks.

THREAD: 15 of the most useful razors and rules I've found.

Rules of thumb that simplify decisions.

Bezos' Razors:

• If unsure what action to take, let your 80-year-old self make it.

• If unsure who to work with, pick the person that has the best chances of breaking you out of a 3rd world prison.

Skinner's Law:

• If procrastinating on an item, you only have 2 options:

1. Make the pain of not doing it greater than the pain of doing it.

2. Make the pleasure of doing it greater than the pleasure of not doing it.

Luck Razor:

• If stuck with 2 equal options, pick the one that feels like it will produce the most luck later down the line.

I used this razor to go for drinks with a stranger rather than watch Netflix.

In hindsight, it was the highest ROI decision I've ever made.

Bragging Razor:

• If someone brags about their success or happiness, assume it’s half what they claim.

• If someone downplays their success or happiness, assume it’s double what they claim.

The map is not the terrain.

Jijo Sunny
@JijoSunny

1/ 👋 Excited to share what we’ve been building at https://t.co/GOQJ7LjQ2t + we are going to tweetstorm our progress every week!

Week 1 highlights: getting shortlisted for YC W2019🤞, acquiring a premium domain💰, meeting Substack's @hamishmckenzie and Stripe CEO @patrickc 🤩

2/ So what is Brew?

brew / bru : / to make (beer, coffee etc.) / verb: begin to develop 🌱

A place for you to enjoy premium content while supporting your favorite creators. Sort of like a ‘Consumer-facing Patreon’ cc @jackconte

(we’re still working on the pitch)

3/ So, why be so transparent? Two words: launch strategy.

jk 😅 a) I loooove doing something consistently for a long period of time b) limited downside and infinite upside (feedback, accountability, reach).
cc @altimor, @pmarca

4/ https://t.co/GOQJ7LjQ2t domain 🍻

It started with a cold email. Guess what? He was using BuyMeACoffee on his blog, and was excited to hear about what we're building next. Within 2w, we signed the deal at @Escrowcom's SF office. You’re a pleasure to work with @MichaelCyger!

5/ @ycombinator's invite for the in-person interview arrived that evening. Quite a day!

Thanks @patio11 for the thoughtful feedback on our YC application, and @gabhubert for your directions on positioning the product — set the tone for our pitch!