"expert reaction to a preprint reviewing the evidence on the origins of SARS-CoV-2"
https://t.co/6kG6rstweP
All your natural origin friends in one place ;)
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 7, 2021
Origins of SARS-CoV-2: A Critical Reviewhttps://t.co/j4A4rtmi8S
via @Topo_Ligio
Fallacy of the "straw mouse", denying evolution in wild type mice, when the claim is actually that it may have "evolved" in hACE2 mice, NOT wild mice. pic.twitter.com/7LCnSAhw6g
Human lung xenograft & adenovirus hACE2 mice need to be immunosuppressed/deficient e.g. SCID or Rag1-2 KO2 mice, so as not to reject the allograft cells & transgenic ACE2.
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 8, 2021
So, why do you think N501Y would emerge in TG hACE2 mice without a functional immune system or mouse ACE2?
Didn\u2019t N501Y come up in ACE2 TG mice too? https://t.co/cRR1qlTUtB
— Stuart Neil (@stuartjdneil) July 7, 2021
Are you just going to quote the entire history of TG mice for CoV research?
— Stuart Neil (@stuartjdneil) July 7, 2021
We know they had Th mice for recombinant CoV infection.
But it\u2019s all irrelevant
They needed to have the right virus. And thus far is there is zero evidence that they did.
So maybe you can tell me why you get adaptive mutations in mouse passage outside spike? Those should happen in Tg mice too. Where are they?
— Stuart Neil (@stuartjdneil) July 7, 2021
https://t.co/I90OOCJg7o
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 8, 2021
I suspect that the reason for the emergence of N501Y in this specific experiment is that the balb/c mice used in the experiment were non hACE2 mice and immunocompetent mice.
It's a simple point, that you are wrong about N501Y
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 10, 2021
"Taken together, these patterns of detectable selection suggest that the adaptive value of signature 501Y lineage RBD mutations may have only manifested after a selective shift that occurred shortly before November 2020"
They haven't even done the basic research.
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 11, 2021
They conjured up a straw lab, the bsl4 lab
Most bat coronavirus work was done at the older complex in xiaohongshan. The labs (plural) and their locations are listed here along with documented biosafety issues:https://t.co/ewo9oZUuqU
That was a surprise. So many well-known supporters of SARS2\u2019s natural origin join forces to publish an opinion piece in\u2026Zenodo \U0001f602https://t.co/led9ZcIokp
— Rossana Segreto (@Rossana38510044) July 8, 2021
2. Worth Reading her investigations and those of @hijodelcuervo as well:
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) March 16, 2021
Robert Kadlec: https://t.co/OEo8WxT50S
Engineering Contagion:https://t.co/xE5P2F2cn7
Dark Winter:https://t.co/p8eUubd9bU
Bioport/Emergent Biosolutions, Hauer. Kramerhttps://t.co/JFGIZsUrCV
4. Some recent investigation of Emergent Biosolutions, kept afloat with generous help of Kadlec and Azar, and now currently minting it with vaccine production..
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) March 16, 2021
A billion doses no less!https://t.co/VtZx0HprvN
Exposed in NYT https://t.co/EcI8n43nEj
How One Firm Put an \u2018Extraordinary Burden\u2019 on the U.S.
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) March 9, 2021
Emergent Biosolutions
HHS- Kramer - Kadlec- Karesh - EcoHealthhttps://t.co/WCcDZJ106G
Finally picked up by mainstream media after the excellent research by @_whitneywebb & @hijodelcuervo & just a little by @BillyBostickson https://t.co/9Wmb8SQ1qH pic.twitter.com/1Rf5VhtJfh