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JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz

 2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.
3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117. https://t.co/LBc8eCk3f9
4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved. https://t.co/74dr2pFiRg
5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
6) “New variants of Sars-CoV-2 are being created all the time but the vast majority of them go absolutely nowhere.
It was only when it became obvious that measures in Kent were failing that Public Health England realised the outbreak was being driven by a new variant.”
7) “#SARSCoV2 isn’t the only virus that can linger for an unusually long time within the human body. Ebola virus RNA has been detected in the semen of men a year after recovery. Some people stay infected with norovirus – a common stomach bug – for more than six months.
8) “One man in the UK has excreted infectious poliovirus for at least 28 years. The man had been shedding mutated virus for so long that researchers writing about his infection said that he, and other chronic excretors, pose an “obvious risk to the [polio] eradication programme”!
9) “But the real problem isn’t chronic infection – it’s a situation where pandemic is so out of control that the virus has endless opportunities to mutate into new variants. That situation is a reality in the UK and in dozens of other countries with dangerously high case rates.
10) ““These are all edge cases, but if you have enough people infected over a long time, you run the risk of hitting those edge cases,” says Hodcroft. It is not surprising that some of the most worrying new variants – from Brazil, South Africa and the UK –
11) ...”emerged from parts of the world with relatively high levels of transmission. “When you have millions of people infected, with millions of viruses replicating in each one, there are lots of chances for the virus to explore new mutations and combinations,” says Lauring.
12) ““If we had control of the virus, we wouldn’t be seeing as many variants pop up, because there wouldn't be as many opportunities for evolution to happen.”
13) Since Sars-CoV-2 infects cells relatively quickly, in most cases it enters a host, replicates and then swiftly infects someone else, leaving little time for the virus to acquire many genetic changes.
14) When the virus enters the body of someone who is already immunocompromised, their body is constantly applying evolutionary pressure on the virus – pushing it to evolve into new and, in some cases, more infectious forms.
15) My take: the moral lesson is that, when given time and opportunity, the virus finds a way. The virus is a cunning mutating beast that will try every way to defeat us if we let it keep proliferating. We must stop it FAST, or else it will evade: https://t.co/Zk46pouYLM
16) And the virus will even evade people who has had prior immunity and prior antibodies to the older common #SARSCoV2. Such as this example — here not even people were protected from severe disease even if with prior immunity. https://t.co/yqgeNJsgzj?
17) Now just look where we are... #B117 is threatening to dominate the US soon next month as well. Florida especially. https://t.co/I7zIjne6nD
18) It’s now growing so fast in Florida, #B117 is already at 10% of all cases. And doubling time in 9 days or maybe even less. https://t.co/DlHtxqaXAr
19) If we go for full suppression, then we can have this too https://t.co/6HkE2IoDTY

More from Eric Feigl-Ding

Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Breaking—UK scientists just reported a case-control study that the mutated UK 🇬🇧B.1.1.7 variant is not associated w/ more severe #COVID19— “found no significant differences in hospital admissions and case fatality at 28 days, & occurrence of reinfections”, says @mvankerkhove

2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.

3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.

4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.

5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.

All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
COVID
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
⚠️TWO DIFFERENT #COVID19 PANDEMICS—Many think with cases dropping that pandemic is nearly over. But truth is, there are now 2 different #SARSCoV2 pandemics diverging—old strain is waning, while the more contagious #B117 strain is dominating. We will be soon slammed very hard. 🧵


2) Here is what is really going to happen... most countries are having a gentle case decline with R(e) currently around 0.9. But this is deceiving. The #B117 is still relatively rare so far, so the R is being influenced mostly by the old common variant. But not for long...


3) Here is what is going to happen... currently R is ~0.9 in many places, but with the more infectious #B117, the R will jump 50% approximately. And it is inevitable (all CDC and Danish models say this) that B117 will take over as the reigning dominant variant soon...


4) and when that happens, what worked before to keep the pandemic contained at R of 0.9 will no longer work. Here is the model for Alberta, 🇨🇦 by @GosiaGasperoPhD. The B117 dotted red line will soon dominate and drive a new surge in latter half of March and April.


5) And Denmark 🇩🇰 CDC has found the same thing. I GQR works now for keeping R around 0.9 or even 0.8, will absolutely not work anymore once #B117 variant takes over. Forget about it. We will be hit hard. But there is a way—if we suppress R to 0.7 or less.
https://t.co/gOq0put4H5
COVID19
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
📍DOUBLE REINFECTIONS—wow, both PM Justin Trudeau and Biden’s HHS Secretary Becerra got *reinfected* with #COVID19–from same conference—➡️when did Becerra last get infected? May 18th 2022—not even a full month ago! Trudeau in Jan 2022. I worry it’s reinfections due to #BA5/#BA4.


2) #BA5 and #BA4 are worrisome. They are surging and they have high reinfection potential. Your past BA1/BA2 doesn’t substantially protect you from #Ba5/4


3) Excess deaths—the new #BA4 & #BA5 variants of the coronavirus are currently the **fastest growing** strains in the US & UK. ➡️They are exponentially replacing all other past strains. Learn from South Africa’s early warning signs and their excess deaths. #CovidIsNotOver #COVID


4) Is it a Paxlovid rebound for Becerra, as some are asking? Unclear—Paxlovid rebound usually only happens at day 10-14 that we know of and have data. The FDA says it’s 1-2% rebound but I counted 12% from this Pfizer graph submitted to FDA.


5) and yes, #ba5 / #BA4 are very problematic. they are 2x more resistant than even BA2 for neutralizing the virus compared to those who had breakthrough reinfections from older Omicron.
CATEGORY PDFMAKERAPP GRAB THIS READWISEIO SAVE READWISEIO SAVE THREAD THREADER COMPILE SUMMARIZE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST IN — "Camp Auschwitz" insurrectionist of the Capitol siege was just arrested this morning in Newport News, VIrginia.

2) this guy was just arrested.


3) We cannot have a repeat of the fascism from WW2. This is @Schwarzenegger’s speech was so powerful.


4) My wife @andreafeigl1’s 🇦🇹 great grandfather secretly fought Hilter’s Nazi regime & smuggled many Jews to safety as an aircraft engineer. He was thrown into a concentration camp, and escaped.

She knows a few things about Nazi history—Jan 6th was downright fascist. Read 👇


5) So this cover is from a semi-tabloid magazine in Germany, according to @andreafeigl1. But even so, how did such a magazine still get it so damn right?! Maybe Germany 🇩🇪 has seen this kinda fascism before...
LEGAL
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Stupid—Oregon church has huge 74+ person #COVID19 outbreak after dozens of maskless churchgoers stood onstage singing & clapping inside a packed indoor venue for Easter Sunday service. The Peoples Church, is vowing to do continue church service on Sunday.

2) Now, the Oregon Health Authority says that at least 74 people associated with the church have tested positive for the coronavirus — one of the state’s largest workplace outbreaks.

3) “In a statement, the church’s leaders attributed the outbreak to a recent rise in covid-19 cases in Marion County, Ore.

Murray said the church, which has held in-person services throughout the pandemic, intends to continue with in-person ceremonies on Sunday.

4) Who saw this coming? Countless scientists. If only airborne-denialists didn’t muzzle the airborne aerosols science.
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More from Science

Sri Krishna
Sri Krishna
@tellkrish
With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3


CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4


So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5
SCIENCE
Dr Naomi Wolf
Dr Naomi Wolf
@naomirwolf
1/Just had an interview scheduled with @goddeketal, Dr Simon Goddek, the post-doctoral researcher at the Faculty of Mathematics and Statistics in the field of biotechnology, at an unnamed Dutch university. This researcher has been publicly pointing out that the paper that...

2/ the PCR test as the gold standard underlying global "lockdowns" was passed after maximum ONE day of peer review, as opposed to the average at that same journal of 172 days in 2019. Also that several authors have conflicts of interest. Unfortunately we were forced to cancel..

3/ because he was strongly advised by his university to maintain silence and not speak publicly -- to step back from this issue. I learned from a source that his university was heavily assailed by many complaints. Other scientists who have signed the review criticizing the PRC..

4/test, the "Retraction Request Letter", a critique that got worldwide attention, have also been bombarded with attacks, their relatives are being called at night, and their universities assailed. Some are at risk of losing jobs. Even former employers are being harassed. I..

5/ Note : scientists around the world are being silenced and harassed if they speak up in normal criticism of the scientific methods or conclusions used to advance the lockdown agenda and COVID testing. This is not post-enlightenment scientific discourse, this is how scientists
SCIENCE
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foone
foone
@Foone
I think I've permanently confused KiCAD
it's reminding me that I need to connect this capacitor to Nothing


attach this end to ground, this end to +5v, and this end to THE VOID

I accidentally made all the capacitors gigantic and they won't fit anymore

halp


gonna design an ISA card using some of these

it's gonna be tricky to fit in the case


that's from this
SCIENCE
Jimmy Bernot PhD \U0001f990\U0001fab1\U0001f3f3\ufe0f\u200d\U0001f308
Jimmy Bernot PhD 🦐🪱🏳️‍...
@JimmyBernot
Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t]
#ScienceTwitter
imgs: https://t.co/hH5YsfS0ay https://t.co/kVurE6BbTS


1st some background on the parasites I got. Hookworms are blood-feeding nematodes that live in the intestine of mammals including cats, dogs & humans. ~500 million people are infected with hookworm, mostly in tropical and subtropical areas including the southern USA

Infection with many worms (100+) can cause anemia, which is most problematic in kids, pregnant women, and the elderly. This clinical study was launched to try to develop a vaccine against hookworms to prevent infection

People become infected when baby worms living in the soil penetrate their skin. Baby worms hatch from eggs that infected people poop out. Where plumbing is scarce, poor waste disposal is a common source of heavy infections (100s to 1,000s of worms)

I volunteered to be vaccinated with an experimental hookworm vaccine (I was also paid). After vaccination, the vaccine (or placebo idk) was tested by infecting me with 50 hookworms (Necator americanus) that penetrated my skin from a patch of gauze I wore on my wrist for 1 hour
SCIENCE
10-K Diver
10-K Diver
@10kdiver
1/

Get a cup of coffee.

In this thread, I'll help you understand the basics of Binomial Thinking.

The future is always uncertain. There are many different ways it can unfold -- some more likely than others. Binomial thinking helps us embrace this view.


2/

The S&P 500 index is at ~3768 today.

Suppose we want to predict where it will be 10 years from now.

Historically, we know that this index has returned ~10% per year.

If we simply extrapolate this, we get an estimate of ~9773 for the index 10 years from now:


3/

What we just did is called a "point estimate" -- a prediction about the future that's a single number (9773).

But of course, we know the future is uncertain. It's impossible to predict it so precisely.

So, there's a sense of *false precision* in point estimates like this.

4/

To emphasize the uncertainty inherent in such predictions, a better approach is to predict a *range* of values rather than a single number.

For example, we may say the index will return somewhere in the *range* of 8% to 12% (instead of a fixed 10%) per year.

5/

10 years from now, this implies an index value in the *range* [8135, 11703]:
SCIENCE

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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
🌺श्री गरुड़ पुराण - संक्षिप्त वर्णन🌺

हिन्दु धर्म के 18 पुराणों में से एक गरुड़ पुराण का हिन्दु धर्म में बड़ा महत्व है। गरुड़ पुराण में मृत्यु के बाद सद्गती की व्याख्या मिलती है। इस पुराण के अधिष्ठातृ देव भगवान विष्णु हैं, इसलिए ये वैष्णव पुराण है।


गरुड़ पुराण के अनुसार हमारे कर्मों का फल हमें हमारे जीवन-काल में तो मिलता ही है परंतु मृत्यु के बाद भी अच्छे बुरे कार्यों का उनके अनुसार फल मिलता है। इस कारण इस पुराण में निहित ज्ञान को प्राप्त करने के लिए घर के किसी सदस्य की मृत्यु के बाद का समय निर्धारित किया गया है...

..ताकि उस समय हम जीवन-मरण से जुड़े सभी सत्य जान सकें और मृत्यु के कारण बिछडने वाले सदस्य का दुख कम हो सके।
गरुड़ पुराण में विष्णु की भक्ति व अवतारों का विस्तार से उसी प्रकार वर्णन मिलता है जिस प्रकार भगवत पुराण में।आरम्भ में मनु से सृष्टि की उत्पत्ति,ध्रुव चरित्र की कथा मिलती है।


तदुपरांत सुर्य व चंद्र ग्रहों के मंत्र, शिव-पार्वती मंत्र,इन्द्र सम्बंधित मंत्र,सरस्वती मंत्र और नौ शक्तियों के बारे में विस्तार से बताया गया है।
इस पुराण में उन्नीस हज़ार श्लोक बताए जाते हैं और इसे दो भागों में कहा जाता है।
प्रथम भाग में विष्णुभक्ति और पूजा विधियों का उल्लेख है।

मृत्यु के उपरांत गरुड़ पुराण के श्रवण का प्रावधान है ।
पुराण के द्वितीय भाग में 'प्रेतकल्प' का विस्तार से वर्णन और नरकों में जीव के पड़ने का वृत्तांत मिलता है। मरने के बाद मनुष्य की क्या गति होती है, उसका किस प्रकार की योनियों में जन्म होता है, प्रेत योनि से मुक्ति के उपाय...
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Hermann Peterscheck
Hermann Peterscheck
@petershk
For fun I made a Robinhood account. It took me 5 minutes to sign up, get approved and transfer funds for trading...

Here's some details... Read on.

...it took me another 5 minutes to get qualified for options.

If I share a sign up I get "free shares" and I can share as much as I want up to 500$ worth.

The main UI has a prepopulated "list" of stocks/crypto to watch and links to news.


Clicking a stock opens a "trade" button that looks like this.

Notice options is first, buy second.

Options took me to an approval process (which took about a minute) and now away I go trading Baba options.


Buying stock looks like this. It emphasizes fractional shares.
TRADING
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Vibhu Vashisth \U0001f1ee\U0001f1f3
Vibhu Vashisth 🇮🇳...
@VIBHU_Tweet
MAHARAJA CHHATRASAL BUNDELA was the great Bundela King who revolted against the Mughal ruler Aurangzeb.
Chhatrasal Bundela was born in year 1649 CE in Maur Hill of Bundela region to Champat Rai and Lal Kunwar. He was the descendent of Rudra Pratap of Orchha.


His ancesters were the vassals of Mughal Emperor. He drew inspiration from his father and revolted against the alien rule of Mughals. He was just 12 yrs old when his parents died in fight against the Mughal Army of Aurangzeb in 1661.

When his beloved father attained martyrdom in the year 166, the young Chatrasal was present in the last battle of his father against the Mughal and from these valiant campaigns,..

..he gathered the courage to free Bundelkhand from Aurangzeb’s rule.
He joined the Mughals initially, and was recommended by the Rajput King Mirza Jai Singh to be recruited in the Mughal Army in order to support their Deccan Campaigns.


But serving the alien rule of Mughals which brought chaos and misery to Bundelkhand was unacceptable for Chatrasal Bundela and his father’s incessant struggle against the Mughals kept the fire of independent Bundelkhand alive in his heart.
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WORLD OF SANATAN DHARMA
WORLD OF SANATAN DHARM...
@world_sanatan
MINUTE DETAILS ABOUT THE ATTACK ON SHAISTA KHAN AT LAL MAHAL

Remarkable Commando op

A long 🧵 but worth your time

Aurangzeb sent his maternal uncle Shaista Khan with powerful army over 1,50,000 on the request of Badibegum Sahiba, Adilshahi sultanate

1/


Shaista Khan entered Deccan to kill Chhatrapati Shivaji Maharaj & to destroy his empire. Shahista Khan captured a lot of province and fort of Chakan near Pune.

2/


Till 3 years he gave lot of troubles to the subjects of Chhatrapati Shivaji Maharaj and he personally made Lal Mahal his destination to live at , which was the property of Chhatrapati Shivaji Maharaj . Lal Mahal, where Chhatrapati Shivaji Maharaj spent his childhood.

3/

1. In the April 1663 Chhatrapati Shivaji Maharaj personally made a surprise attack on Shahista Khan in the Lal Mahal Pune.

2. Chhatrapati Shivaji Maharaj attacked with 300 soldiers at the midnight while Lal Mahal had strong security of 1.5 lac soldiers for Shahista Khan.

4/

3. He entered in Pune, he made a drama of wedding ceremony to enter in Pune near Lal Mahal.

4. During the night they made big hole at the wall of Lal Mahal and entered into the palace.

5/
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Anu Satheesh
Anu Satheesh
@AnuSatheesh5
Dhanwanthari Temple, Nelluvai
Thrissur District, Kerala.🚩🚩

ॐ नमो भगवते वासुदेवाय धन्वन्तरये अमृतकलश हस्ताय
सर्वामय विनाशनाय त्रैलोक्यनाथाय श्री महाविष्णवे नमः
#temples

Dhanwanthary Moorthy temple in Nelluvai is one among the ancient temples in Kerala.


Dhanwanthari is the Deva of Ayurveda. It is said that the murthy at the temple was installed by Ashwani Devas and it was the same idol worshipped by Sri. Vasudevar in the Dwapara Yuga. The Dhanvanthari Moorthi is facing towards the west
@SriramKannan77


Smrata-Matrarti-Nasanah', Srimad Bhagavatam states that the one who remembers the name of Dhanwantari will be cured and protected from all the diseases. Temple is known for its Oushada Prasada with Ayuvedic medicinal values, called Mukkudi.


Mukkudi Nivedyam is a very special offering to Dhanwantari. It is prepared by using dry ginger, pepper, pomegranate peel, cumin seed, turmeric, rock salt and other medicinal items. It is offered during 'Usha- Pooja', and is later on distributed to the devotees present there.
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