Wow. 1 in 3 hospitalized with #COVID19 gets readmitted to the hospital within a few months after discharge. ~48,000 UK patients.
Great animated lecture on #LongCovid by @Dr2NisreenAlwan, animated by @VickiGSP using info from UK @IndependentSage experts.
Lecture again by @Dr2NisreenAlwan
LONG COVID\u201430% of hospital recovered #COVID19 patients end up back in hospital in <5 months; up to 12% die of complications. \u201cwe really need to prepare for #LongCovid. It\u2019s a mammoth task to follow up w/ these patients, but monitoring needs to be arranged\u201dhttps://t.co/h0y8WUn8sQ pic.twitter.com/Pk8GhQc9J5
— Eric Feigl-Ding (@DrEricDing) January 18, 2021
Psssst... pass it on:
— Eric Feigl-Ding (@DrEricDing) January 17, 2021
\u27a1\ufe0f COVID LUNG is worse than smoker\u2019s lung.
"Post-COVID lungs look worse than any type of terrible smoker's lung we've ever seen. And they collapse. And they clot off. And the shortness of breath lingers\u201d says Dr @BKendallMD. #COVID19 pic.twitter.com/h3PrzzN3rR
More from Eric Feigl-Ding
2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.
3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.
4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.
5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.
All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
Why a SARS-CoV-2 variant that's 50% more transmissible would in general be a much bigger problem than a variant that's 50% more deadly. A short thread... 1/
— Adam Kucharski (@AdamJKucharski) December 28, 2020
2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.
same thing happened in Boston in another immunocompromised person that was sick for 155 days.
3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.
Immunocompromised 45 year old suffered from #COVID19 for 155 days before he died. The virus was changing very quickly inside the man's body\u2014it acquired a big cluster of >20 mutations\u2014resembled the same ones seen in #B117 & #B1351. (NPR audio Part 1 of 2)\U0001f9f5https://t.co/7kWiBZ1xGk pic.twitter.com/ZJ7AExB78Y
— Eric Feigl-Ding (@DrEricDing) February 8, 2021
4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.
2) NPR report audio part 2 of 2:
— Eric Feigl-Ding (@DrEricDing) February 8, 2021
Dr. Li couldn't believe what they found. "I was shocked," he says. "When I saw the virus sequences, I knew that we were dealing with something completely different and potentially very important." pic.twitter.com/HT3Yt6djFd
5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
HHS @SecBecerra has tested positive for COVID-19 again, the agency just announced. Last time he tested positive was May 18, after attending the G-7 Summit.
— Ariel Cohen (@ArielCohen37) June 13, 2022
2) #BA5 and #BA4 are worrisome. They are surging and they have high reinfection potential. Your past BA1/BA2 doesn’t substantially protect you from #Ba5/4
\U0001f4c8Surging #BA5 & #BA4 variants in both US & England. It\u2019s looking like #Ba5 is the new fastest strain\u2014which has ~10x increased in England in 1 month. Also notice that older #Omicron #B11529/#BA1 are already near *extinct*. I worry the \u201cnew\u201d Omicron BA1 bivalent vaccine is behind. pic.twitter.com/kLNH0gzPk3
— Eric Feigl-Ding (@DrEricDing) June 9, 2022
3) Excess deaths—the new #BA4 & #BA5 variants of the coronavirus are currently the **fastest growing** strains in the US & UK. ➡️They are exponentially replacing all other past strains. Learn from South Africa’s early warning signs and their excess deaths. #CovidIsNotOver #COVID
To anyone pointing to South Africa to suggest the impact of the omicron wave has been 'mild' or that the BA.4/5 haven't had much impact, I'd urge you to look at excess deaths. 29,500 excess deaths since Jan (omicron wave) & a peak of 1,844 excess deaths/wk during BA.4/5 wave.\U0001f9f5 pic.twitter.com/r7kLzmD5dG
— Dr. Deepti Gurdasani (@dgurdasani1) June 11, 2022
4) Is it a Paxlovid rebound for Becerra, as some are asking? Unclear—Paxlovid rebound usually only happens at day 10-14 that we know of and have data. The FDA says it’s 1-2% rebound but I counted 12% from this Pfizer graph submitted to FDA.
4) Look at these 97 Paxlovid patients here with viral RNA load data over time. Of 97, i conservatively counted at least 12 of 97 (12%) with viral load rebound after day 10. Even more if you count rebound after day 5. Thus, FDA\u2019s 1-2% doesn\u2019t match up here. https://t.co/bNoqj5W3Sk pic.twitter.com/B3Kh0Lc1A4
— Eric Feigl-Ding (@DrEricDing) May 5, 2022
5) and yes, #ba5 / #BA4 are very problematic. they are 2x more resistant than even BA2 for neutralizing the virus compared to those who had breakthrough reinfections from older Omicron.
Unfortunately neutralization experiments found that BA.4/5 is 2x more resistant than BA.2 to the blood obtained from vaccinated individuals who had a breakthrough infection with BA.1 or BA.2. 4/ pic.twitter.com/MEOPXuqTgg
— Dr. Jeff Gilchrist (@jeffgilchrist) June 13, 2022
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