BC COVID
Saved by @CalicoSalsa

Breaking—UK scientists just reported a case-control study that the mutated UK 🇬🇧B.1.1.7 variant is not associated w/ more severe #COVID19— “found no significant differences in hospital admissions and case fatality at 28 days, & occurrence of reinfections”, says @mvankerkhove

 2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.

https://t.co/vCoETA8CPn
3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.
4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday. https://t.co/w6ZrtwKB4n
5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.

All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have. https://t.co/F39PjnaiPu

More from Eric Feigl-Ding

Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
⚠️TWO DIFFERENT #COVID19 PANDEMICS—Many think with cases dropping that pandemic is nearly over. But truth is, there are now 2 different #SARSCoV2 pandemics diverging—old strain is waning, while the more contagious #B117 strain is dominating. We will be soon slammed very hard. 🧵


2) Here is what is really going to happen... most countries are having a gentle case decline with R(e) currently around 0.9. But this is deceiving. The #B117 is still relatively rare so far, so the R is being influenced mostly by the old common variant. But not for long...


3) Here is what is going to happen... currently R is ~0.9 in many places, but with the more infectious #B117, the R will jump 50% approximately. And it is inevitable (all CDC and Danish models say this) that B117 will take over as the reigning dominant variant soon...


4) and when that happens, what worked before to keep the pandemic contained at R of 0.9 will no longer work. Here is the model for Alberta, 🇨🇦 by @GosiaGasperoPhD. The B117 dotted red line will soon dominate and drive a new surge in latter half of March and April.


5) And Denmark 🇩🇰 CDC has found the same thing. I GQR works now for keeping R around 0.9 or even 0.8, will absolutely not work anymore once #B117 variant takes over. Forget about it. We will be hit hard. But there is a way—if we suppress R to 0.7 or less.
https://t.co/gOq0put4H5
COVID19
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Stupid—Oregon church has huge 74+ person #COVID19 outbreak after dozens of maskless churchgoers stood onstage singing & clapping inside a packed indoor venue for Easter Sunday service. The Peoples Church, is vowing to do continue church service on Sunday.

2) Now, the Oregon Health Authority says that at least 74 people associated with the church have tested positive for the coronavirus — one of the state’s largest workplace outbreaks.

3) “In a statement, the church’s leaders attributed the outbreak to a recent rise in covid-19 cases in Marion County, Ore.

Murray said the church, which has held in-person services throughout the pandemic, intends to continue with in-person ceremonies on Sunday.

4) Who saw this coming? Countless scientists. If only airborne-denialists didn’t muzzle the airborne aerosols science.
ALL
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
📍DOUBLE REINFECTIONS—wow, both PM Justin Trudeau and Biden’s HHS Secretary Becerra got *reinfected* with #COVID19–from same conference—➡️when did Becerra last get infected? May 18th 2022—not even a full month ago! Trudeau in Jan 2022. I worry it’s reinfections due to #BA5/#BA4.


2) #BA5 and #BA4 are worrisome. They are surging and they have high reinfection potential. Your past BA1/BA2 doesn’t substantially protect you from #Ba5/4


3) Excess deaths—the new #BA4 & #BA5 variants of the coronavirus are currently the **fastest growing** strains in the US & UK. ➡️They are exponentially replacing all other past strains. Learn from South Africa’s early warning signs and their excess deaths. #CovidIsNotOver #COVID


4) Is it a Paxlovid rebound for Becerra, as some are asking? Unclear—Paxlovid rebound usually only happens at day 10-14 that we know of and have data. The FDA says it’s 1-2% rebound but I counted 12% from this Pfizer graph submitted to FDA.


5) and yes, #ba5 / #BA4 are very problematic. they are 2x more resistant than even BA2 for neutralizing the virus compared to those who had breakthrough reinfections from older Omicron.
CATEGORY PDFMAKERAPP GRAB THIS READWISEIO SAVE READWISEIO SAVE THREAD THREADER COMPILE SUMMARIZE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
SCIENCE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
ATROCIOUS big pharma price gouging of insulin:

This crying mother can’t afford the $1000 for her son’s insulin.

📌yet, it only costs pharma $5 to produce.

📌Insulin was invented 100 years ago by Fred Banting—who donated patent for $1 to make it free for all.

Let that sink in.


2) Insulin is one of the most disgusting cases of price gouging ever.

America has long taken a free market approach to pharmaceuticals.
Drug companies haggle separately over drug prices with a variety of private insurers across the

3) “Meanwhile, Medicare, the government health program for those over age 65 — it’s also the nation’s largest buyer of drugs—is barred from negotiating drug prices. That gives pharma more leverage, and it leads to the kind of price surges of EpiPens, opioid antidotes, & insulin.”

4) In 2018:
Johnson & Johnson CEO made $30M
Pfizer CEO made $28M
Merck CEO made $18M
Eli Lilly CEO made $16M
Gilead CEO made $16M

Meanwhile:

📌Americans spent $535B on Rx drugs

📌1/4 of diabetics rationed insulin to survive

📌500K Americans went bankrupt from medical bills.

5) What’s the right price patients should pay for medications? ZERO dollars, because no copay ==> more patients get their medicine ==> saves lives and saves money. Copays decrease adherence, and copays hurt patients who actually need them.
FINANCE

More from Covid

Laurie Garrett
Laurie Garrett
@Laurie_Garrett
In this thread @EricTopol describes evidence from Israel of waning anti-#SARSCoV2 immunity months after mRNA #COVID19 #vaccination.
But as I wrote https://t.co/NZk0v3r6Dc the explanation is about timing. People ARE immune, but after months response goes
MORE

2/ ..into the B cell memory compartment, and circulating neutralizing antibody levels in blood plummet. THAT IS NORMAL with vaccines. The challenge is #DeltaVariant speed of replication is 2-3Xs faster than "normal" #SARSCoV2 so it outpaces antibody production from memory.
COVID
Sumon Chakrabarti
Sumon Chakrabarti
@TorontoIDDoc
I've been wanting to write this thread for a while. It has been inspired by hearing a common thought: why can't people just "listen"? If people just followed the rules, we wouldn't be in this mess. I think this is oversimplification of the problem with COVID: 1/

It is true, there are people who haven't been following guidelines (by definition that happened a LOT at Christmas/NYE in my region), but even before, we know transmission in private gatherings happens. 2/

These private gatherings are pictured to be big raucous parties, but in reality, even before lockdown, this is just people having dinner, watching TV, doing things we did before on a daily basis. These little ripples when added across the country make a big wave.. 3/

...and little can be done about this apart from positive messaging. You can't very well have police patrolling neighbourhoods across the country. 4/

Next thing is we keep hearing over and over and over, stay home. There are diminishing returns with this advice, but also, most people who can stay home ARE. So what's the issue? There are a HUGE # of people who can't stay home because they work in essential jobs 5/
SOCIETY , COVID
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Katherine MacKenzie
Katherine MacKenzie
@FakeNewsHuntres
@PeterSchorschFL @CDCgov @NikkiFried Just now 6 kids are in hospital with Covid in Fl pneumonia is a given, here’s what a 9 yr old with pneumonia looks like. He spent 3 days in P-ICU 6 days in all in the hospital. If you could prevent a child from going through this just by wearing masks why the hell wouldn’t you?
COVID
Thread Reader App
Thread Reader App
@threadreaderapp
@Christi22657596 Salam, the unroll you asked for: THREAD: As news stories drop about COVID+ pandemic deniers &… https://t.co/I0mZD4so2m Enjoy :) 🤖
COVID
Frank Luntz
Frank Luntz
@FrankLuntz
This would also include:

• Tylenol and Advil
• Aspirin
• Pepto-Bismol and Tums
• Benadryl and Claritin
• Sudafed
• Ivermectin‼️

👉🏻 https://t.co/3seDr4CQ8H
COVID

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In 1937, a trucker got frustrated waiting for his cargo to be unloaded. He later sold his company for $1.1 billion.

Here’s the story of how Malcom McLean made a billion dollars and which startup could be following in his footsteps. (Inspired by our episode with @laurabehrenswu)


In the early 1950s, the shipping industry was a dying business.

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As McLean found out, loading ships was difficult and slow.

A truck or train would deliver items to the port. Each item was unloaded separately, recorded, and carried to storage.

When a ship was ready, each item was taken from storage, counted again, and hauled on-board.


The cost of this labor was significant. As one expert at the time explained:

“A four-thousand-mile voyage for a shipment might consume 50 percent of its costs in covering just the two ten-mile movements through two ports.”


Yet, despite the industry’s issues, it felt little pressure to change.

Foreigners were barred from operating domestically. Cartels ran international routes. And gov. subsidies eased the pain of labor costs.

Reshaping the industry needed an outsider.

Enter Malcolm McLean.
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Dr. Anandibai Joshi

Upon her birth on 31 March 1865 she was named Yamuna, after the holy river. Her parents Gunputrao Amritaswar Joshee & Gungabai Joshee came from a long lineage of wealthy landlord family in Kalyan of Bombay Presidency, whose wealth was now waning.


Anandi was the sixth of 10 children, & had 4 brothers (only two of which survived) & five sisters. Her father was particularly fond of her, as she was a bright child with an inquisitive mind. Being an educated man himself, Ganpatrao assured that his daughter was taught Marathi.

As was common practice she was married at a tender age of 9, to Gopalrao Joshi, a 29 year old widower who worked as a postal clerk in the same city. After marriage her husband named her ‘Anandibai’ (which means ‘Joy of my heart’).

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Nicolas
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A brief analysis and comparison of the CSS for Twitter's PWA vs Twitter's legacy desktop website. The difference is dramatic and I'll touch on some reasons why.

Legacy site *downloads* ~630 KB CSS per theme and writing direction.

6,769 rules
9,252 selectors
16.7k declarations
3,370 unique declarations
44 media queries
36 unique colors
50 unique background colors
46 unique font sizes
39 unique z-indices

https://t.co/qyl4Bt1i5x


PWA *incrementally generates* ~30 KB CSS that handles all themes and writing directions.

735 rules
740 selectors
757 declarations
730 unique declarations
0 media queries
11 unique colors
32 unique background colors
15 unique font sizes
7 unique z-indices

https://t.co/w7oNG5KUkJ


The legacy site's CSS is what happens when hundreds of people directly write CSS over many years. Specificity wars, redundancy, a house of cards that can't be fixed. The result is extremely inefficient and error-prone styling that punishes users and developers.

The PWA's CSS is generated on-demand by a JS framework that manages styles and outputs "atomic CSS". The framework can enforce strict constraints and perform optimisations, which is why the CSS is so much smaller and safer. Style conflicts and unbounded CSS growth are avoided.
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Tip from the Monkey
Pangolins, September 2019 and PLA are the key to this mystery
Stay Tuned!


1. Yang


2. A jacobin capuchin dangling a flagellin pangolin on a javelin while playing a mandolin and strangling a mannequin on a paladin's palanquin, said Saladin
More to come tomorrow!


3. Yigang Tong
https://t.co/CYtqYorhzH
Archived: https://t.co/ncz5ruwE2W


4. YT Interview
Some bats & pangolins carry viruses related with SARS-CoV-2, found in SE Asia and in Yunnan, & the pangolins carrying SARS-CoV-2 related viruses were smuggled from SE Asia, so there is a possibility that SARS-CoV-2 were coming from
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David Rothkopf
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Pretending that voting for Trump or denying climate change or suggesting the solution to every problem is more guns is a legitimate point of view, worthy of respect is not "how America works." It is how it dies.

People in a free society are entitled to any point of view no matter how obviously wrong or outlandish or destructive provided they do not impose their views on others.

But suggesting that something ignorant or divorced from reality warrants the same kind of treatment in public debate as something based in fact or at least credible is absurd and when done on behalf of a society in public media or academic settings it is self-destructive.

We would not grant media coverage or much bandwidth at all to a group that argued that unicorns exist or that there was a pot of gold at the end of the rainbow. Yet views like denying climate change or basing policy decisions on sweeping, obvious lies, are just as unsound.

Somewhere, somehow, judgments must be made. Some behaviors are wrong and must be condemned. Someone must challenge lies and demand facts. Coddling people who embrace idiocies does not help them no matter how loudly they demand to be coddled.
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