The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL

The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4

There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16

Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16

Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16

Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16

Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz

There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20

Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20

Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20

Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20

The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL

In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18

Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18

Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18

France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18

A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0

There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14

First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14

France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14

Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14

There is a recent new word in Chinese that I think deserves introducing into the Western neoreactionary canon.

The word is 内卷 (nei-juan) which has been translated as "involution". Originally a Chinese phenomenon it increasingly applies anywhere there is modernity.

To capture the essence of what "involution" means it helps to picture a spiral in your mind. Our modern narrative says that as we progress technologically we should progress OUT of the spiral and have more free time to be capable of ever more amazing things...

But what if the progression of technology and society actually sends us WITHIN the spiral in an infinite number of ever-decreasing circles? What if we are walking DOWN the spiral staircase of progress rather than UP?

"Involution" in its original meaning has been used to describe agrarian societies and how their development actually leads to self-perpetuating processes that prevent change and progress rather than encourage it.

Increased food production has limited many civilisations and sent them into stagnancy rather than allowed them to grow. This stagnancy can continue for millennia in safe environments till threatened, other times it drives the civilisation into extinction from external threats.

Xi Jinping's speech at Davos boiled down to: The world has no choice but to do business with China, and if you want to do business with China, you need to stop criticizing our tyranny and questioning our lies about the

Xi's address to the World Economic Forum will serve as well as any other moment for historians to mark the beginning of the Authoritarian Era. He said nothing new, but he restated the narratives and demands of Chinese fascism from a post-pandemic position of aggressive strength.

For the first time, Xi spoke to a world that is beginning to accept the tenets of authoritarianism, thanks to the incredible political and economic damage from China's coronavirus. China's ideals have become as viral as Covid-19.

Thanks to the pandemic, the political elites of the world now universally see their citizens as dangerous mobs that must be tightly controlled for their own good. Most of them always thought that way, but now they can say it openly and act aggressively on their prejudices.

Xi clearly stated that China will not be contained, censured, or judged for its actions. He denounced Western ideals of human rights as "arrogance" and imperialism. After Covid and Biden's inauguration, he sees no nation with the strength or will to thwart China's ambitions.

We were pulled over by Nigerian police the last time I was in Naija and this man saw a weapon certification in my wallet and was shocked. The weapon certification had a list of weapons I was qualified to shoot. He yelled "you fit shoot this thing?" I said "yes nau".. he-

Yelled "so if I give you this my gun, you fit shoot am well". I said "boya you should give me and let us see? 🤷🏾‍♂️" He said "who qualify you?". I said "This thing clearly says "Missouri State. Na yankee nah! I mean USA". He yelled "Sergeant Ojo! Sergeant blah blah come o!"

He looked at the uber driver "you come down! And come here! Sergeant! Search the car and search it well. Na huge case dey here! This man fit get guns inside the car! Search it well!" 🤣🤣🤣 I was just laughing! I was like "Mr Police, why you dey harrasss me?"

They all started to cock their guns anyhow "praaaa move! Kini kan! Stay there! Don't move! If you moveeee?!" I was just laughing" They started telling the bystanders to not move! People were putting hands on their heads like we had done something wrong.

The uber driver started crying "I said guy calm down, no dey give this people chance." They searched o! And found nothing as expected. The boss asked where I lived, and I explained I just came back from the US. I presented my passport and boarding passes to him to back it up.