BC WORLD
Saved by @Alex1Powell

The latest S:N501 focal build is now up, with data from 28th Dec:

We can see new sequences from Italy, Israel, Spain, France, & Ireland in the SE England variant (501Y.V1) & Switzerland in the South African variant (501Y.V2).

1/8

https://t.co/PEU7dhptO6

 In 501Y.V1 (SE England variant), we can see 1 new sequence from France & Spain, each. The French sample has a travel history to the UK.

3 new sequences are from Israel (marked 1 & 2). Zooming in on '2' (divergence view) shows they are identical, indicating 1 introduction.

2/8
There are 7 new sequences from Ireland, found roughly in 5 places on the tree (4 are singletons, 3 cluster together - 2nd 'group' from the top).

These indicate at least 5 introductions, but we need to zoom in on the 3 that cluster to see more clearly.

3/8
Zooming in to the 3 that cluster together (divergence view), shows it can be difficult to distinguish introductions sometimes, especially as we expect strong travel links between the UK & Ireland, & may only be sampling the total diversity present in Ireland.

4/8
14 new sequences from Italy are scattered across the tree - some alone & some clustering.

Zooming in on a few clusters shows some seem to be linked, while others are harder to determine.
4 seem to be clearly linked as 1 introduction.

5/8
In 501Y.V2 (SA variant), there are 2 new sequences from Switzerland. As they sit quite separately within this cluster, this indicates two separate introductions to Switzerland.

6/8

https://t.co/6Cux2E3Y6y
Additionally, a new graph showing the proportion of different variants in selected countries is also up.

Note the sharp in increase of N501 (bright pink) at the end of many graphs: this indicates increased interest in sequencing N501 samples.

7/8

https://t.co/AUkR60o0GO
While more sequencing is great, you can see how switching to preferentially sequencing N501 samples will distort our ability to track other variants, both current & emerging.

Long-term, we need coordinated & regular sequencing of many samples to track #SARSCoV2 variants!

8/8
For those for whom it's helpful, there's also a new 'N501-noUK' build up which reduces the number of UK sequences.
*Importantly* one /should not/ use this tree to discern connections between sequences - use in conjunction with the full N501 tree!

https://t.co/9md0yn9Qgp

9/8
Notably, in the '501-noUK' build, an Israeli sequence seems to 'stick out' from the main 501Y.V1 cluster - we've already been in touch with Israeli scientists & there issues with this sequence (mixed base frequencies at some sites) - do not read much into its position!

10/8

More from Dr Emma Hodcroft

Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw


There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12


In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12


The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12


Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0


There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14


First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14


France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14


Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14
FOR LATER READ
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Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4


There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16


Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16


Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16


Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16
SOCIETY
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The focal S:N501 build is now updated with data from 13 Jan!

There are a total of 247 non-UK & non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

I'll do an additional thread later on, covering S:E484 & the 'Ohio variants'.

1/18

https://t.co/3bdttjKVl4


There are 244 new sequences in 501Y.V1 (B.1.1.7) from Australia, Belgium, Denmark, Germany, India, Israel, Italy, Netherlands, New Zealand, Norway, Portugal, Singapore, Spain & USA, as well sequences as from Ecuador and Greece for the first time.

2/18


Greece has 3 new sequences in 501Y.V1 for the first time. They indicate 2 separate introductions.

Ecuador has 2 sequences for the first time. They also indicate 2 separate introductions.

3/18


The USA has 61 new sequences (orange), from Florida, Minnesota, California, Pennsylvania, & New York.

A few of these represent separate introductions. Others form distinct clusters that may indicate ongoing local transmission.

4/18


Israel has 35 new sequences (orange). Some of these show separate introductions, but many link with older sequences, indicating ongoing local transmission.

5/18
SOCIETY
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL


Denmark has 43 new sequences (in orange). These indicate additional introductions, as well as further expansion of the existing large local transmission cluster we saw previously (shown in zoomed divergence view).

2/12


10 new sequences from Portugal (orange) indicate additional, separate introductions.

3/12


Singapore has 5 new sequences (yellow). These indicate at least 5 separate introductions for the total of 6 sequences, with two identical sequences likely being 1 introduction.

4/12


5 new sequences from the US, from Florida & California (older sequences crossed through).

Zooming in (divergence view) on the California cluster, the relationship between these samples is difficult to infer from phylogenies alone.

5/12
WORLD

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THREAD

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#Iran’s regime has a network of apologists/lobbyists in the US influencing foreign policymakers.

Kaveh Afrasiabi was recently arrested for acting as an agent of #Iran's regime.
https://t.co/fJq6jRtBha

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@atsumori5834 An Argentinian variant of Italian fascism with stuff from German National Socialism that took an unexpected turn and led to a globalist and progressive ideology. Menemism was a conservative variant but not faithful to the doctrine and from that new generation arose Kirchnerism.

The Kirchnerists are antifascists and "supercapitalists", which is a term used by Juan Perón to refer to a deformed, monstrous style of government, the result of the fusion between Marxism and Capitalism (Globalism).

The Kirchneristas dubbed themselves Peronism and little by little they are making the orthodox Peronists treated like outdated garbage and surely soon persecuted as if they were authentic NationalSocialists. A tragedy.

Peronism is full of progressives, globalists, left liberals, feminists, zionists...
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Right: Alberto Fernandez, actual leader of the Peronist movement. Pathetic.


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Josh
Josh
@Josh731_
-Thread-

The Bolshevik Revolution was Jewish, 6/8 Soviet leaders from Lenin to Gorbachev were Jewish AND all three Presidents since the (fake) fall of the Soviet Union are Jewish

Lenin✡️
Stalin✡️
Khrushchev✡️
Brezhnev✡️
Andropov✡️
Gorbachev✡️
~
Yeltsin✡️
Medvedev✡️
Putin✡️


First Soviet government mostly Jewish:

Funded by International Jewish bankers;

https://t.co/qdmhsmSRFz

Ariadna Tyrkova-Williams on Bolshevik revolution:

“In the Soviet Republic, all the committees and commissaries were filled with Jews”

https://t.co/iysRhViRe3


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https://t.co/vWoUqvmXc4


Stalin:

B’nai Brith report - Stalin is Jewish (pg 35)
https://t.co/Km9UClfrRt

Stalin's Jewish mother (Jewish Cup Kiddush covered with a shroud - on the grave of Stalin's mother) https://t.co/XXAkeC6wID

Soviet Analyst, Volume 31, Issues 1-7
https://t.co/ycZG4XshNC


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Nikita Salomon PEARLMUTTER. (img 1) https://t.co/aVLCetMf3w

Another source for Pearlmutter (img2)
https://t.co/m6JzRrD1BJ

"Khrushchev, also, promptly added that the Soviet Government is based today on Jewish leadership"
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MEWAS
MEWAS
@KeithMEWAS
As witch-hunt #3 gets underway by @BeatriceJanzon
@sverigesradio @sr_ekot against me, Keith Begg, a citizen of Ireland and Sweden and no doubt some members of the FB Group I would like to post some questions to the above:
🆘Is it ethical, that the tactics and antics of a state


media station, paid for with taxpayers money, can infiltrate a Private FB group and try to discredit them? This is done in the most authoritarian of states.
🆘Is it ethical that the Honorable David Nabarro from @WHO had to issue a press release due to being deliberately


misquoting in Swedish media?
🆘Are these headlines reflective of what you would see in free media in a democracy, when the rest of the world was posting quite opposite headlines about Sweden?
🆘Does the deliberate distortion of information on Swedish TV constitute any


breaches of trust? Why was it done? After all when the government changed its C19 strategy on the Gov website, they deemed it a mistake?
🆘Not to mind the Italian embassy having to issue three statements over false claims by Tegnell


which were picked up by the media. Do I as a private citizen think that @RSF_en made a big mistake by recognizing Sweden as #4 in terms of Freedom of the Press? ABSOLUTELY. We want to know what they based their decisions on. Because it is clear to many
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Mentorshipzim
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MIGRATING TO AUSTRALIA
International borders are currently closed and migration for offshore candidates next to zero but I will share this info so you can prepare, if interested. There are still things you can do in preparation

Migrating to Australia is a process and a half. It is costly and the process is long. It can take a year or so for the whole process to come full cycle. What I can not emphasise enough is that IT IS WORTH IT. There are a few visas available for trades people.

Please note that Australia does not classify trades people. You are either one or not. Whether you are class 2 or class 1, apprenticeship trained or not, if you have the required experience and pass their skills assessment you get the same certificate.

The most common visa is the State nomination visas, followed by the employer nominated visas. I will expand on these below. Between 2012 and 2017 you could easily get PR straight up, but they have since changed the rules to balance and spread people across other states.

PR allows you to work anywhere in Australia. Most people chose Western Australia as that is where most of the mining happens, leaving other states with skills shortage. Before we go into details about visas, I will share what you need to be eligible.
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