Did we get dietary saturated fats all wrong? The #HADLmodel provides a new understanding and an opportunity to get it right. THREAD👇👇👇
@simondankel @kariannesve

Increased dietary saturated fatty acids lead to increased cholesterol in lipoproteins, but we don’t know why. Enter the #HADLmodel, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that ensure optimal cell membrane fluidity and cell function.
We propose that circulating lipoproteins enable appropriate redistribution of cholesterol molecules between specific cells and tissues, to accomodate changes in dietary fatty acid supply, due to our omnivore nature and variable intake of fatty acids. #HADLmodel
Our #HADLmodel implies that circulating levels of LDL change for protective, not for pathological reasons; an SFA-induced raise in LDL cholesterol in healthy individuals is a normal response, while a lack of this needed response may reflect a deeper pathology in lipid handling.
Circulating lipoproteins may change for pathological reasons, when regulatory mechanisms become disrupted by pathogenic processes related e.g. to inflammatory processes. Diverging lipoprotein responses in healthy versus metabolically unhealthy individuals support this view.
Low grade inflammation can interfere with several fine-tuned signaling pathways necessary for homeostasis, including proper lipid handling. Altered circulating cholesterol levels may here reflect underlying pathogenic processes, unrelated to saturated fat intake. #HADLmodel
Dietary factors causing chronic low-grade inflammation, driven by diet-microbiome interactions, should receive more attention. The role of saturated fats in pathogenesis may be misconceived and greatly exaggerated. #HADLmodel
Is the #HADLmodel impossible? Is there more evidence to support the model? What else do we need to test in high-quality studies? Keep the discussion going - fair and factual. We need to improve the conversation on dietary fats. #publichealth #dietaryguidelines
@zoeharcombe @bigfatsurprise @DrAseemMalhotra @LDLSkeptic @ufferavnskov @malcolmken @LeventalLab @fedonlindberg @drmarkhyman @LorenCordain @chriskresser @ChrisMasterjohn @garytaubes @ProfTimNoakes @PeterAttiaMD @marionnestle @whsource @RobertLustigMD

More from Science

Localized Surface Plasmon Resonance - an overview | ScienceDirect Topics

https://t.co/mzS7vVSREJ

https://t.co/353PdAX2fa

https://t.co/3yBImjOdd4

In some cases, almost 100% of the light energy can be converted to the second harmonic frequency. These cases typically involve intense pulsed laser beams passing through large crystals, and careful alignment to obtain phase matching.

You May Also Like