AGI Significance Paradox: As progress accelerates towards AGI, the number of people who realize the significance of each new breakthrough decreases.

We wake up each day with the same attention budget as everyone else. This is the one thing all humans equally share.

Spending that attention budget by doing this is what gives meaning to our lives.

It's is only through doing that we learn. It is only through learning that we find meaning.

Yet many of us waste attention budget exclusively on consumption. Seeking the random dopamine hits that tickle our curiosity. Yet we seek only the convenient things to do.

Activities that are convenient, that takes little effort don't consume a lot of attention. But enough of these small distractions will. But unfortunately, there's little learning taking place.

All Biological life on earth is possible because of a discrete digital mechanism of preservation and replication.

The mechanism of signaling between the superorganism we know of as bacteria and its ongoing war against viruses is through a digital mechanism.

The source of innovation in biology is in this milieu of microbiome and viromes that are ubiquitous in every complex multicellular organism on earth. Humans are walking ecologies and cannot survive stripped of these ecologies.

We can picture this as a cloud of digital interaction that surrounds all of us.

The cells of multicellular creatures however do not communicate in the same way as bacteria. The DNA of mammals are sequestered from daily activity so as to prevent wear and tear.

Star Wars has a simple dichotomy between good and evil. But as the stories have evolved, the nuances between these distinct poles also has acquired a richness that is hard to dismiss.

In the latest trilogy, we discover a dysfunctional civilization even after the defeat of the empire. The argument that the remnants of the empire make is that the galaxy stills seeks a need for order. Order and chaos are at seperate poles where evil is aligned with order.

We know however from D&D alignment charts that good and evil, order and chaos can exist in many combinations:

It is also interesting that the Sith (the Evil sorcerers) only come in pairs as opposed to the Jedi that can be entire communities. Apparently, to sustain evil one has to restrict agency and individuality to just a few. A community of evil-doers very quickly turns on itself.

So at one extreme we have evil, order, individuality and at the other we have good, chaos, collective. Which brings up the question, what is the definition of evil and good? Something that we took for granted ever since the first Star Wars movie.

In physics, energy is that which is causally invariant or symmetric with respect to time. Said differently, energy is never created or destroyed, it is conserved in the universe.

Now there is a question about information. Is information causally invariant? Does information remain the same with respect to time? To understand this, let's first understand what energy is, then attempt to understand what information is.

The strange thing about energy is that it is this universal currency that seems to be interchangeable between the different forces in nature (i.e. electromagnetic, strong, weak and gravity). It is that thing that makes change possible.

Now let's assume that the universe is computational in nature. That is, anything we see in nature is a consequence of computation. That is, there is computation underneath the physics that is driving the universe to change.

What does it mean then that information is conserved in this computational universe? Also, how is energy conservation related to information conservation?

Did you know that all the nuclear bombs we exploded in the '40s-50s-60s have permanently contaminated all the steel the world has produced since then? All steel in the world is divided into two categories: pre-1945 non-contaminated steel, and post-1945 contaminated steel.

How?

Nuclear bombs (including the tests) create a lot of radioisotopes that are not found in nature. For example Cobalt-60 (a radioactive version of Cobalt-59). And since the 1945 Trinity test, these have all dispersed in the atmosphere.

What does this have to do with steel?

The process of manufacturing steel uses atmospheric air (or atmospheric oxygen). Some of the radioisotopes like Cobalt-60 get pulled in too, and as a result, any steel produced after 1945 has embedded in it some of these radioisotopes, sitting there emitting gamma rays.

Why do we care about traces of radioisotopes in steel? When making Geiger counters, or medical devices to check for radioactive contamination, or astronomical instruments, the emissions from the contaminated steel would interfere with the measurements.

So we need pre-1945 steel

Pre-1945 non-contaminated steel is called "low background steel". And when we need it, where do we get it from?

We go, find pre-World-War-II sunken shipwrecks, and then salvage the steel (and lead) from those to build our instruments which need heavy radiation shielding.

I think I've permanently confused KiCAD
it's reminding me that I need to connect this capacitor to Nothing

attach this end to ground, this end to +5v, and this end to THE VOID

I accidentally made all the capacitors gigantic and they won't fit anymore

halp

gonna design an ISA card using some of these

it's gonna be tricky to fit in the case

that's from this

With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

The Nature versus Nurture is a debate about scientific doctrine. It is a debate about the correct way of explanation for cognition.

The Representation versus Non-Representation shares the same debate. It is also about the correct way of explanation for cognition.

It is also the difference between thinking in nouns versus thinking in verbs. Nature and Representation have deep roots in Western thinking. It is a functionalist and reductionist way of thinking that meets its limits when analyzing complex adaptive systems.

It is perhaps due to this Western bias that concepts from the study of complex systems have had little traction in modern society. It is of course, more than a Western bias, but a human bias to seek out simple causal explanations of this world.

But the world is complex and messy. Spiral dynamics which is an evolutionary model of individuals and society explains how models of the world shape ourselves and our civilization.

Wonder why your Ph.D./Master's application is being rejected?

Here are some insider reasons (from a committee member) that result in such "Love Letters" 👇

- A Short Thread

1) First, you should know that sometimes, an independent reviewer is required (especially in the US) to review applications even after PIs must have selected their candidates. So, even if any bias slips through the PI, the independent reviewer will pick it up.

2) Having said this, there are three major issues that application reviewers/committees often find with your application. These three components make your applications almost challenging to assess.

3) NUMBER ONE - Incomplete Applications

This occurs when you do not upload the requested documents needed to evaluate your file. Think of a candidate that did not send a GRE score when the institution clearly requires it for admission.

4) NUMBER TWO - Error laden Essays

This is particularly interesting because based on reports from this resource person, it is not particularly about how little your experience is but how you communicate it error-free or at least extensively minimized. This gives headache!