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https://t.co/zsc2eBVI4e Tons of great preclinical work on TIE2 MOA showing clear correlation to SC integrity, adult-onset glaucoma, and disease-modifying effects. See mosaic if interested
can you share the preclinical work you describe along with the papers?
— James Brandt (@jmsbrandt) November 20, 2020
What do KOL's think of the new MOA: Special session held at ARVO 2019 to discuss Tie2 for Glaucoma. $ARPO then completed a closely watched P1b with a topical formulation. Now, a P2b trial in 195 pts enrolled within 3 mos, a month ahead of schedule, in the middle of a pandemic.
SOC is PG (-7 mm Hg IOP) +/- adjunct (-1 to -1.5 mm delta). Best efficacy adjunct is Rocklatan (-1.5), but AE profile: hyperemia (60 vs 15%), pruritus (8 vs 2%) site pain (20 vs 7%) vs PG , + other AE’s not seen with PG: 10% conjunctival hemorrhage, 15% verticillata. Almost DOA
But, sells $80 to $100M/yr US (same as $ARPO MC ha!). Every 0.3 mm reduction critical towards delaying vision loss. Rocklatan MOA was projected to make it a $1B drug, until AE profile (& payor delays) killed launch. $ARPO thesis: Raz efficacy >/= Rocklatan, without AE baggage.
What do you do when your hot stock is falling fast?
💥 (a thread)
Check your goals.
When do you need this money?
Now? In a few days? In a few years?
If you have time to wait, then it could make sense to hold on for now.
Remember your why.
Stocks rise and fall. It’s the nature of the market, and swings are the price of investing (h/t @morganhousel).
Just think about Apple. Amazing rally over the past few decades…with a lot of big
What they tell you:
— Callie Cox (@callieabost) September 24, 2020
If you invested $100 in Apple's IPO and and held shares until today, that investment would be worth about $100,000.
What they don't tell you:
If you invested $100 in Apple's IPO and held shares until today, you would've endured 23 declines of 20% or more.
Back to the why. If your why behind buying this stock hasn’t changed, then it might be best to wait this drop out.
The NIO ET7 boasts 621mi range (150kWh battery) for $70k-$80k & Level 3 autonomy. This prices right in-between Model 3 SR+ & base Model S.
2/ $TSLA is down -6% today, largely on this news. Not surprising, but TSLA bulls aren't flinching from this. NIO ET7 isn't really expected to hit the roads until late next year–enough time for Tesla to refresh S/X & boost pack size, TSLA bulls think.
$NIO is up 8.5% today.
3/ BYD (1211 HK) was up 6.7% in China on Monday partially on the news of its surprise unveiling this morning of 3 new "super hybrid" models (PHEV): Qin PLUS DM-i, Song PLUS DM-i, & Tang DM-i.
$BYDDF is up 3.5% today
4/ BYD is also benefiting from #NIODay, as investors are excited about NIO ET7 specs, but it is still at least a year out. More investors are discovering BYD & how far ahead it is TODAY. BYD Han in particular already looks similar to NIO ET7...
$BYDDF $BYDDY
5/ ...and you can buy a Han today for only $32k. Lots of investor attention has been brought to BYD Blade battery, as well.
More on BYD here: https://t.co/rbiX4sZtdN
https://t.co/SYLpij5dTe
$BYDDF $BYDDY
Ok - first, a *quick* history lesson - in the last ~3 months, I have been increasingly obsessed w/ learning about monoclonal antibodies. It started as a simple pattern recognition that a lot of the biotechs I was investing in were in this space - $HGEN $PRVB $MGNX $ONCT etc.
Not to mention, all of these new COVID therapeutics ( $LLY $REGN ) were antibody based - what the heck exactly are these things? I found myself watching basic videos - like this simple 3 minute cartoon summary...
.. to this podcast on the history of monoclonal antibodies, like this Nature podcast: https://t.co/iXcq56RR5l And a bunch of more academic / scientific white papers and articles that are far too dry to share here
Probably a good time to add that I barely made it past high school biology - my academic and professional background is all based around finance / math / SaaS - so as much as I'm interested in biotechnology, it's all self-taught and I needed to start with the basics
Q: Why is $TSLA up 6% on no news?
GB: Because it was down 8% yesterday on no news - unless you call a 10 bp rise in treasury yields and $BTC collapsing news. You still short?
I had a two-day email exchange with a guy I used to work with who now runs a $600M hedge fund and shorted $TSLA at $600. He\u2019s now kicking himself as $TSLA approaches $700. Amazingly:
— Gary Black (@garyblack00) December 28, 2020
1/ He\u2019s a value investor who doesn\u2019t own growth stocks, but thinks he can short growth stocks.
2/ Q: Of course I’m still short. It’s up another 30% since we talked two weeks ago. It’s all mo’.
GB: $TSLA MIC Y has a 4 mo wait. It’s entering India. Analysts are playing leapfrog raising PTs. Active mgrs have to own it or get fired. It’s cheap at 80x 2022 EPS vs 55% growth.
3/ Q: Your earnings estimates are like twice consensus.
GB: The Street’s been wrong on $TSLA forever. Why do you listen to them? You really shouldn’t be short going into Biden’s inaugural speech and the FY’21 volume guide at the end of Jan. You’re going to get run over.
4/ Q: Whatever.
GB: Did you rent a Tesla for a week like I told you?
Q: No. You know I don’t drive.
GB: Did you build a $TSLA 5-yr volume, earnings, cash flow model?
Q: No. No one can forecast out 5 years.
GB: Did you talk to any Audi or BMW dealers? Or Tesla owners?
5/ Q: I don’t have time for that.
GB: Q, you haven’t done any real research. $TSLA ‘s up 40% since you shorted it. Maybe you should figure out why it keeps going up.
Q: It keeps going up because people like you are pumping it.
GB: You’re giving people like me too much credit.
Please do not invest money you can't afford to lose.
"We are seeing a new reality," says @alexisohanian. "This is a drastic shift--the menu is open with this combination of technology and ubiquity of connected people sharing insights and opinions." pic.twitter.com/vuiRb9crOy
— Squawk Box (@SquawkCNBC) January 28, 2021
https://t.co/ypc8ViK1Gq
This is personal for a lot of people. We've never seen anything like this.
These aren't just random comments on the internet, community is meaningful, this is a person standing up in a stadium of millions of people they consider allies/friends/confidants speaking their painful truth and getting a a roar of applause and cheers and support.
This is going to be in textbooks one day
I did not *write* much this year, but I was lucky to have a few things published anyway:
1. My essay “What *was* primitive accumulation?” — which has been online since 2017 — got its permanent published form in @EJPTheory vol. 19, issue 4:
The article argues against the recent revisionist accounts of primitive accumulation.
2. My highly critical review of Gareth Stedman Jones’s biography of Marx was published in Historical Materialism: https://t.co/tTh3FUaW1s An excerpt:
3. My engagement with @martinhaegglund’s This Life: Secular Faith and Spiritual Freedom appeared in @LAReviewofBooks, as part of a symposium on Hägglund’s book.
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SPAC - $SSPK Silver Spike Acquisition Comp
They are merging with WM Holdings, Inc who owns Weedmaps. Founded in 2008. Lead by CEO Chris Beals. Former life-sciences attorney (important - will come in later).
Started a new position today. Will be working on my first in-depth write-up.
— Plant (@plantmath1) December 16, 2020
Basic Description:
The business is a two-sided marketplace which serves customers and sellers of marijuana products.
Who are they?
On the consumer side, https://t.co/sHZKPFCY7I which is a marketplace for standardized marijuana products.
Weed Maps is the world’s largest base of cannabis users with over 10M MAUs, 90% of which are cannabis users, and a stunning 70% are DAILY users.
A key part of the marketplace is the differentiation between alcohol/tobacco and cannabis. Cannabis is *not* a standardized product so Weedmaps compiles millions of data points from strain traits, user feedback, effects, etc., to suggest the best products for the user.
Weedmaps is operating at a 1.5B GMV run rate. With cannabis illegal on the Federal level, they do not currently take a percentage of this GMW but stated that they plan to with Federal legalization.