So here's something interesting about our latest 'surge'. If one goes to https://t.co/unPSmmc8Mg you can toggle between 'confirmed' cases, 'probable' cases and both of them together.

1 of 16: WE ARE ALL JEWS HERE: THE STORY OF RODDIE EDMONDS

One of the most moving and relevant stories of the Battle of the Bulge, or any American Soldier in any war, is that of Master Sergeant Roddie Edmonds, a Knoxville, Tennessee native, who served with the 106th Infantry.

2 of 16:

Roddie was captured early on in the Battle of the Bulge, on December 19th, when Panzer forces plowed through his unit.

He, along with almost his entire regiment, was forced to surrender.

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The men were transported to the Stalag IX-A POW camp in Ziegenhain, Germany.

Roddie was the senior enlisted American Soldier at the site. As such, he was the conduit between all American Soldiers and their German captors.

4 of 16:

In late January, the camp’s commandant, Major Siegmann [pictured here], ordered Roddie, a Christian, to identify all Jewish Soldiers and order them to stand in formation by themselves the next day.

[Jewish Soldiers were a minority within American units]

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Throughout WWII, captured Jewish Soldiers were often tortured and then killed by their German captors.

In fact, Jewish Soldiers had been told to bury their dog tags before capture. The dog tag identified Jews with the letter “H” for Hebrew.

Offered a guy a ride from Yaba to Obalende this morning. Just as we're approaching Alagomeji, uncle asked me if he can drive. Said he's not comfortable being driven by a woman. I parked and told him to come and take the wheel. Once he got down, I just zoomed off. Arrant nonsense

Funny thing is the guy is quite young. He can't be more than 25. How can someone that young have this sort of mentality?

I actually did not think that the guy could have wanted to get away with my car at the time. Now that I think of it though, that's a big possibility. We need to be careful out there. These thieves now have different ways of operating

Unless we pass laws which support people to enable them to self-isolate properly, any improvements to test & trace will have marginal impact and cases will simply spiral out of control once again as we ease lockdown in December.

A short thread on what we can do and why 👇
1/

Improving the currently poor rates of self-isolation is actually the key point, which many scientists, politicians, & commentators do still seem to be missing.

This requires good public health communication, proper support for those who need to self-isolate, & trust.
2/

Massive testing and tracing will only significantly reduce
transmission if positive cases isolate effectively. Yet
currently fewer than 20% of those who should isolate are fully adherent.

I don't think I need to explain why it's so critical to improve these rates.

3/

Survey data shows intention to adhere to test/trace/isolate behaviours is higher than self-reported adherence: whilst 76% of people intend to share contacts, only 50% of people correctly recognise symptoms &
just 12% get a test, 18% isolate, & 11% of contacts isolate properly.
4

Self-reported ability to self-isolate
is three times lower in those who earn less than £20,000 per year or have less than £100 saved.

5/

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

Thread:
A year ago, at this hour exactly I was in Maujpur in northeast Delhi. For days, weeks & months, I -- like several other reporters -- filed multiple stories on the #DelhiRiots. On the violence, the perpetrators, the victims, the burnt homes & shops, the fear.

I remember every minute of Feb 23, 2020 -- from the speeches to smoke billowing from afar. What I can't ever forget is the face of a man who sat alone in front of a shop, his kurta dusty and torn, blood on his forehead, unable to answer who he was & where he wanted to go.

I've his photo, I never posted it anywhere, and I won't either. He was in such shock, and there was no help around. I tried talking to him but he didn't say a word. He was numb.

It'll take me years before I can fully write down what happened that afternoon -- a stampede, stones flying all around me, a colleague who held nu hand & ran, another who lost her slipper for a minute, tear gas, my inhaler, salt.

I sent my mother messages, my hands trembling. At 1 am, I was home -- my head buried inside a pillow between my parents.