BC SOCIETY
Saved by @jay_millerjay

AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

 In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10
...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10
...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10
...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10
...survival rate after 60 days for the standard-dox group was 0%; and 100% for the pro-dox group.

#AVCT isn't looking to improve chemotherapies by 25-30%, like most drugs in clinical trials.

Its pre CISION has the potential to improve the safety profile - and thus the... 6/10
...efficacy (via increased dosing) - by MULTIPLES. It is not an exaggeration to state that pre CISION could transform the chemo market - in fact, the overall oncology space. Survival rates could increase materially - as the mouse trials demonstrated. 7/10

https://t.co/XOEE45CBtZ
For #AVCT, it stands to reason that if the pro-dox trial is a success, then the pre CISION tech is also highly likely to work for other existing chemotherapies. @avacta has a pipeline of at least a dozen others in development.

AVCT holds the global exclusive licence over...8/10
...the pre CISION tech. It is also combining the tech with its second platform, Affimers - to create a third therapeutic platform, named TMAC.

TMAC will produce Affimer Drug Conjugates - a potentially more powerful class of oncology treatment than Antibody Drug Conjugates. 9/10
More on TMAC and AfDCs another time, but suffice to say that if they do work in man, #AVCT could become one of the most sought after oncology companies, globally.

First though, success for AVA6000 please!

Then hopefully @avacta's first TMAC drug to enter Phase I next year 10/10

More from Society

Coffee Sloth \u2615
Coffee Sloth ☕
@CaseyExplosion
*Heads-up that this thread will feature some extreme examples of homophobia and transphobia.*

Hey folks, have you ever wondered why trans people face constant accusations of fetishism, sexual predation and child abuse/grooming? Well, today let's talk about stochastic terrorism.

So, first we have to talk about what stochastic terrorism actually is. Remember when there was a conspiracy that there was a pedophile ring operating out of a pizza parlour basement, and a crazed gunman showed up? It's that sort of incitement that stochastic terrorism describes.

It's the demonisation or incitement against a group of people or individuals with the intent that other, unaffiliated parties will act upon it; it's the releasing doctored footage and a shooter show up at Planned Parenthood as a direct result of what he's been led to believe.

So with that in mind, let's talk about Russia's extreme anti-LGBT laws that banned the "promotion" of LGBT lifestyles to children. A move that specifically marked LGBT people as a threat to children, and resulted in neo-nazis meting out vigilante "justice" against gay men.


Groups such as this would lure unsuspecting gay men via dating sites, and brutalise and humiliate them on camera. They did so under the guise of combating child abusers, one group calling themselves "Occupy
SOCIETY
wikipedia \u201cseasonal halloween name\u201d brown
wikipedia “seasonal ha...
@eveewing
I’m contemplating leaving @twitter. The platform has proven to be instrumental in harming people with marginalized identities, which normally I wouldn’t blame a media platform for except that @jack has demonstrated negative interest in doing anything about it.

in the past when I’ve thought about this I’ve thought about it from the perspective of my own safety/comfort. And I’m good on that front; I can handle it. But now I’m thinking about it differently: thinking about the people who tell me they join or stay on twitter because of me.

Every time someone in the press refers to me as a “twitter celebrity” (actual phrase that I don’t fully understand or subscribe to but this is what people say) it means that my presence and voice are adding social cachet to a company that I find to be quite terrible.

People tell me that they learn a lot from what I have to say here, and sometimes that it’s their first or only exposure to certain ideas, histories, perspectives, etc. and I have to weigh that too. But I could post that stuff elsewhere.

We’ll see. I’m just thinking aloud for now but I’m watching closely to see what @twitter and @jack do in the coming days and how they respond to what we now know about Cesar Sayoc (beyond one really stupid tweet). Because we know it’s not just him. Big changes need to happen.
SOCIETY
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신념의사나이...
@Belposto_korea
What does Gold- Backed mean?
The Chinese Elders have been accumulating gold for hundreds of years. They are gold-rich. Some of their gold was loaned to the Central Banking System so that it could fund the rebuilding of Europe after the many war-torn years from World Wars I and II

BTW they never returned it but used it to start their financial empire to enslave humanity. This is the Central Bank Banking System./2

Maybe this is why one of the conditions to use their gold for the QFS is the demise and full disclosure of the Central Bank banking system before the RV can take place./3

The Elders have caves of hidden gold and are now using it to gold-back the currencies in the QFS for every country in the world. It is important to understand that the QFS and the money it is about to release is all brand-new currency./4

It was designed by the Alliance to fund the new financial system that will reset all Currencies of the world to Gold-Backed currency./5
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Demagogue_Bingo \U0001f536\U0001f30d\U0001f1ea\U0001f1fa\U0001f95b\u2696\ufe0f\u2694\ufe0f\U0001f989\U0001f41d\U0001f480\U0001f3af\u2638\ufe0f
Demagogue_Bingo 🔶🌍🇪🇺🥛⚖...
@BingoDemagogue
@AuthorMonika No; we have been British here long before we were Scottish. British comes from 'Pritani' which is what the people here called themselves and the whole island before the Romans invaded.

When the Romans were here they Latinised this to Britannia, but also, for example, the Vindolanda tablets found at Hadrian's wall record the locals north of the wall as 'Britunculi' ' the little britons'

Looking at the post Roman period the 'scots' were Irish pirates who started to invade and colonize from the west. There has been a tribal split known between the 'British' - which covered the central belt where most of 'Scots' still live now, and the 'picts' to the North.


Now the latest research on the Picts suggests from their language that they and the 'British' had an originally common source and both from a same root proto-british language.


Then if you move forward to the Declaration of Arbroath - it literally says that the Scots invaded from Ireland and 'expulsis primo Britonibus et Pictis omnio deletis' - 'first routed the British then destroyed every single Pict'
SOCIETY
Sam Parker \U0001f1fa\U0001f1f2
Sam Parker 🇺🇲...
@SamParkerSenate
Shall we do a thread of Blue Checks spewing hatred towards Rush Limbaugh and the rest of us on the Right?

https://t.co/eXLNam2gv4
SOCIETY

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Devdutta
Devdutta
@Devdutta96
Please please please take your cyber security seriously even if you don’t consider yourself a high risk person. Here are a few easy things to start with. 1/n

Switch from WhatsApp to Signal and enable disappearing messages. Most of us cannot stop using WhatsApp entirely but at least turn off back ups to Google Drive or iCloud. 2/n

Do not have private conversations using the messaging service on any social media platform like Facebook, Instagram or Twitter. 3/n

Switch from Gmail to ProtonMail or any other secure email service provider. 4/n


Switch from Google Docs to CryptPad or RiseUp Pad.
CYBER SECURITY , IT PRIVACY , CYBER SECURITY STEPS
asif
asif
@aj_raja
THE LAST PRINCESS OF LAHORE - BAMBA DULEEP SINGH (1869 - 1957)

Thread

Post partition, every morning a weak old woman would board the Model Town bus service headed to the city. The conductor never asked her for money or he would invite anger of the last Queen of Punjab.

1/n


Princess Bamba Sutherland, the eldest daughter of Maharaja Duleep Singh and grand-daughter of Maharaja Ranjit Singh, was born on Sep 29, 1869, in London.

Duleep Singh, the last Maharaja of Punjab was taken away to England by British after annexing Punjab.

2/n


Since he was still a child he was forcibly converted to Christianity and made to adopt British values in order to prevent him from ever thinking about regaining Punjab.

He was also kept away from his mother Maharani Jindan.
When he finally met his mother years later...

3/n

...he was told about his lost kingdom and religion after which he decided to reclaim it from British treachery.
During his struggle he married and had six children, 3 sons & 3 daughters from the 1st marriage.

Bamba was the most colorful character among 6 and was a rebel...
4/n

...like her father and daring like her Grandfather Ranjit Singh. She married Col Sutherland who later became principal of King Edward Medical College.

When she got permission to bring her grandmother Maharani Jindan's ashes to Lahore in 1924, she saw a huge crowd gathered...
5/n
HISTORY
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Anu Satheesh
Anu Satheesh
@AnuSatheesh5
Puthucode Annapoorneshwari Temple,
Palakkad, Kerala 🚩
#keralatemples
अन्नपूर्णे सदापूर्णे शङ्करप्राणवल्लभे 
ज्ञानवैराग्यसिद्ध्यर्थं भिक्षां देहि च पार्वति 

Temple is also called Puthukode Bhaghavathy Kshetram
Parasurama did Prathishta of Devi here. Temple is one amoung 👇


108 Durga temples
Navarathri festival is celebrated in a grant manner here. Annadanam is done daily on these days. The Idichu pizhinja payasam/ Chathachatayam is the main nivedyam in Annapoorneswari temple during Navarathri.
In the mornings, Devi Mahatmyam and Sundarakandam are


recited here daily.
Sri Godavarma Raja gifted lots of rice fields for the maintenance of the temple.
Annapoorneshwari holds Shanku and Chakra in her hands. Puthucode Annapoorneswari Temple is managed by the Naduvil Madom Devaswom.
🙏🕉🙏
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Jaya_Upadhyaya
Jaya_Upadhyaya
@Jayalko1
SRISAILAM: KASHI OF THE SOUTH (AP)
#andhratemples

The divine abode of Mallikarjuna Swamy (Jyotirlinga) and Devi Brahmaramba (Shaktipeeth).

When Ganesha was married before Kartikeya, he left in anger to Kraunch mountain. Shiva and Parvati also followed him there.


Shiva assumed the form of Jyotirlinga and resided on the mountain by the name of Mallikarjuna. Mallika means Parvati while Arjuna is another name of Shiva
It is also said that once, a princess Chandravathi, saw a cow shedding milk on a rock resembling a shivlingam.
@DubeyYash1911


She started praying to the lingam daily and used to offer jasmine (mallika pushpam) daily. Pleased Shiva appeared before her and agreed to wear jasmine garland (mallika pushpmala) on his head permanently. Since then, Shiva became known as Mallikarjun Swamy.


At this place, Shakti took the form of Bhramaram (bee) to kill Arunasur and settled as Bhramaramba Devi. The place is a Shakti Peeth as the neck portion of Devi Sati fell here.

It is said that by merely seeing the hill, one is emancipated from all his sins and worries.
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Erik Torenberg
Erik Torenberg
@eriktorenberg
1/ Someone emailed me asking how to break into VC, so I wanted to answer on Twitter where others could see and contribute to the conversation.

2/ “Being a VC” can mean a lot of different things, so it’s worth asking:

What actual activities do you want to do?

- Deep market analysis?
- Be in the flow of information and people?
- Make deals?
- Work closely w/ founders over time (e.g take board seats?)
- Manage capital?

3/ It’s worth specifying what type of VC you might like to become — as there are different archetypes. E.g.

- Benchmark (Lead series A/B - couple investments a year)
- First Round (Lead seed rounds, partner w/ a few companies a year)
- SV Angel (Make lots of seed investments)

4/ Continued:

Expa - Incubate companies

YC / Village Global - Build a platform to help entrepreneurs at scale

Do you want to join a firm or start one? There’s a lot to consider.

Different paths will require different skillsets & sets of experiences.

5/ Since the person who wrote the email is a young person trying to break into VC by joining a firm (and who doesn’t want to start a company), I’ll tailor this tweet storm to that goal. There’s some overlap.
STARTUPS