AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10
...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10
...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10
...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10
...survival rate after 60 days for the standard-dox group was 0%; and 100% for the pro-dox group.

#AVCT isn't looking to improve chemotherapies by 25-30%, like most drugs in clinical trials.

Its pre CISION has the potential to improve the safety profile - and thus the... 6/10
...efficacy (via increased dosing) - by MULTIPLES. It is not an exaggeration to state that pre CISION could transform the chemo market - in fact, the overall oncology space. Survival rates could increase materially - as the mouse trials demonstrated. 7/10

https://t.co/XOEE45CBtZ
For #AVCT, it stands to reason that if the pro-dox trial is a success, then the pre CISION tech is also highly likely to work for other existing chemotherapies. @avacta has a pipeline of at least a dozen others in development.

AVCT holds the global exclusive licence over...8/10
...the pre CISION tech. It is also combining the tech with its second platform, Affimers - to create a third therapeutic platform, named TMAC.

TMAC will produce Affimer Drug Conjugates - a potentially more powerful class of oncology treatment than Antibody Drug Conjugates. 9/10
More on TMAC and AfDCs another time, but suffice to say that if they do work in man, #AVCT could become one of the most sought after oncology companies, globally.

First though, success for AVA6000 please!

Then hopefully @avacta's first TMAC drug to enter Phase I next year 10/10

More from Society

A long thread on how an obsessive & violent antisemite & Holocaust denier has been embraced by the international “community of the good.”

Sarah Wilkinson has a history of Holocaust denial & anti-Jewish hatred dating back (in documented examples) to around 2015.


She is a self-proclaimed British activist for “Palestinian rights” but is more accurately a far Left neo-Nazi. Her son shares the same characteristics of violence, racism & Holocaust denial.

I first documented Sarah Wilkinson’s Holocaust denial back in July 2016. I believe I was the 1st person to do so.

Since then she has produced a long trail of written hate and abuse. See here for a good summary.


Wilkinson has recently been publicly celebrated by @XRebellionUK over her latest violent action against a Jewish owned business. Despite many people calling XR’s attention to her history, XR have chosen to remain in alliance with this neo-Nazi.

Former Labour Shadow Chancellor John McDonnell MP is among those who also chose to stand with Wilkinson via a tweet.

But McDonnell is not alone.

Neo-Nazi Sarah Wilkinson is supported and encouraged by thousands of those on the Left who consider themselves “anti-racists”.
@Suman68082748 @thetwinkwolff @x_karran_x @Sunil9130 Lets stop the criticism guys. The lad is good. Losses happen. Losses to unranked players happen too. As do wins vs top 10ers. Let's accept both. Remember Sumit and the likes of him are the best we have. See the bigger picture please.

@thetwinkwolff @x_karran_x @Sunil9130 When the Europeans or South Americans were getting quality practice and tourneys week in week out at reasonable costs, our kids were playing on dung courts or learning outdated serve and volley on grass. Appreciate the fact that the last 10 years have been a hell lot better than

@thetwinkwolff @x_karran_x @Sunil9130 the 10 before that. Real change can't come in a day or even in 10 years. So let's grit our teeth and bide our time till we have an organic self sustaining system in place.

@siyer30 @SportaSmile @Cric_Writer @RomilShukla @amanthejourno

@thetwinkwolff @x_karran_x @Sunil9130 @siyer30 @SportaSmile @Cric_Writer @RomilShukla @amanthejourno Tennis is my favourite sport in the universe. Has always been. Will always be. I was in love with Steffi and Pete a lot before I fell for Sachin. And while I would love every toddler in my family to play sports professionally, I won't encourage them to pursue my favourite sport.

@thetwinkwolff @x_karran_x @Sunil9130 @siyer30 @SportaSmile @Cric_Writer @RomilShukla @amanthejourno It will be career suicide. In other sports, I can actually plan for my ward to be the next Lin Dan or the next Tiger Woods or the next Schumacher even from a base in India. With tennis, in 2020 I can't do that realistically. Just doesn't adds up. Even for total freaks of nature.

You May Also Like