Lots of tweets about this today!
Let's see what we can see in the focal S:E484 build!

Phylogenetics (what I do - making 'family trees' from virus genetics) can be very informative to see how different variants are spreading, and how cases

The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4

There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16

Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16

Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16

Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16

A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0

There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14

First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14

France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14

Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14

To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw

There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12

In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12

The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12

Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12

The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL

In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18

Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18

Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18

France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18

My little Jacob Wohl story: August 2016, we're sitting around the trading turrets at my office on a bored to tears slow day. Our receptionist said someone was here for his 2pm appointment. None of us had an appointment on schedule. Who is it? we ask? Some guy named Jacob Wohl 1/

Jacob Wohl, for those out of loop, gained quite a bit of notoriety for becoming the youngest guy to ever get himself barred for life from the financial industry. Now he's waiting in our lobby to pitch something. We're a large merchant bank. 2/

Send him in, we said. In walks young Jacob asking to be seeded with $25mm to start a new hedge fund in exchange for an ownership stake in it. Oh, & he needs an office. And a Bloomberg station. And needs to borrow staff until he can hire some guys. And he needs a leased car... 3/

And he needs an answer today. Right now. Because there's a competing offer from Izzy Englander's firm Millenium (we know those guys well). We fight the urge to literally start laughing, but do ask him...hey, you the same guy who got banned by regulators? He didn't even flinch 4/

He went on about that being untrue & handed over a letter he said was from his lawyer who had confirmed he was not barred, had been vindicated but it 'just wasn't in the system yet at the SEC, CFTC'...whatever that means. 5/

SocialCops’ 10 (base 10) Engineering Commandments — the values that drive everything for the #Engineering Team #InsideSocialCops 🙌

(Thread👇) Tell us if you can relate to any of these? Do you have your own values that guide your decisions? Share them with us! ⛳

0. Coder != engineer

Coders focus just on writing code to make something work. Engineers take a much wider view, focusing on both the problem and every aspect of the solution. 🤓

1. “Import lib”

It's not wise to waste time building tools or libraries if there’s already something that does the same job! Wherever possible, extend existing libraries and contribute back to the community. 💁‍♀️

2. With great power comes greater responsibility

Every choice we make on our platform and every feature we build stands up to a responsibility — helping people make more data-driven decisions and bring about real change for millions of people. 💪

3. Fail fast and keep learning

Failing fast is about doing lots of fast iterations and learning from each, rather than getting stuck on one solution or decision. 👊

Shocking fact: Millennial men are less likely to work than any other age and gender demographic in America.

Today, there are 500,000 young men missing from the U.S. workforce.

Research suggests video games & improved leisure tech plays a role in the problem. 👇 Thread:

Following the 2007 to 2009 recession, 25 to 34 year old men exited high school with fewer middle-skill job opportunities than years prior.

During this time, we saw an increased number of men living with parents & choosing unemployment over lower paying jobs.

It's estimated that 24M millennials live w/ their parents.

1 in 4 living in their parents’ home neither go to school nor work.

What's more surprising? 9 in 10 who lived with their parents a year ago are still living there w/ no plans to leave.

Economists are calling millennial men a lost generation.

According to economist David Dorn:

“If you get to the point where you’re turning 30, you’ve never held a real job and you don’t have a college education, then it is very hard to recover at that point.”

Economists suggest this choosiness is a generational trait.

Forbes interview w/ a high school educated man:

"I’m very quick to get frustrated when people refuse to pay me what I’m worth."
“People feel that they have choice nowadays, and they

at some point we have to recognise that the financial anxiety young people are living through is not normal. monetising all your hobbies is not normal. hustle culture is not normal. glorifying precarious work is not normal. self-optimisation is not normal.

all these issues have a single root and guess what? it's the economic system we live under!! but we're too fucking exhausted to even see an alternative to capitalism because we're so broken and fatigued by it. it doesn't have to be this way, we can seek a different future.

As Mark Fisher argued, it's easier to imagine the end of the world than it is the end of capitalism. We've been utterly brainwashed by every part of our society to think that everything we're experiencing right now is extremely normal! But clearly, capitalism is failing us.

How about instead of “manifesting” money on TikTok, we work towards building a more equal society? Just a thought.

Incredible! People in the replies to this are like “people who hustle will be relaxing when they get wealthy”. That’s IF and not when and still, that’s not a given. The fact we don’t see having a regular full-time job as enough “hustling” or whatever is so scary to me.