Each day brings new challenges, but here's an update to the dedicated S.N501 build, using data from 6 Jan 2021 to keep you going.

There are 42 new non-UK sequences in 501Y.V1 (B.1.1.7) & 7 new non-South-African sequences in 501Y.V2.

1/14

https://t.co/kT1gFsSZn0

There are 42 new non-UK sequences in 501Y.V1 from the Netherlands, Italy, Hong Kong, Finland, Sweden, Germany, USA, Switzerland, Brazil, and the first sequence from 501Y.V1 in Oman.

https://t.co/XA8VR8HiEq

2/14
Oman has their first sequence which falls into 501Y.V1:

3/14
Finland has 12 new sequences (orange), which mostly represent separate introductions. Zooming in (divergence view), we can see 3 of the new sequences are identical (red), which may indicate the cases are connected.

4/14
Sweden has 8 new sequences (orange), which indicate separate introductions.

5/14
Italy has 6 new sequences (orange), which indicate additional independent introductions.

6/14
Netherlands has 4 new sequences (orange), indicating 1 clear additional introduction. The other new sequences cluster with older sequences, possibly indicating local transmission.

7/14
Switzerland has 3 new sequences (orange). 1 is clearly a separate introduction.
Zooming (divergence view), we can see 2 of the new sequences differ by 1 mutation, & connect to a UK sequence. More info would be needed to conclusively determine if this is local transmission.

8/14
Brazil has 2 new sequences, 1 (marked) shows a new introduction. The other connects to a previous sequence. Zooming in (divergence view) we can see this more clearly - they are identical, and this may indicate local transmission.

9/14
Hong Kong, Germany and the USA (from New York), each have 1 new sequence (orange), indicating additional introductions.

10/14
Moving on to 501Y.V2, there are 7 new non-South-African sequences in 501Y.V2, from the United Kingdom (6) and Sweden (1).

11/14

https://t.co/fOPgetG9S8
Sweden has a sequence in 501Y.V2 for the first time.

12/14
UK has 6 new sequences in 501Y.V2 (orange), including 1 from Scotland. Most indicate separate introductions, but 1 new seq links to the older 1 (blue). Zooming (divergence view), they are separated by 1 mutation. This could indicate local transmission or the same exposure.

13/14
As always, the graph of variants per country is updated (remember: as people are preferentially sequencing S:N501 samples, the proportions shown are not accurate outside of UK & Denmark!)

Additionally, the 'reduced UK' S:N501 build is updated!

14/14

https://t.co/c7wlQOLRiq

More from Dr Emma Hodcroft

🎉Happy New Year!🎉

To kick off 2021, here's an update on:
- S:N501 variants (501Y.V1/V2) with data from 31 Dec 2020
- 69/70del variants
- 20A.EU1 variant (most prevalent variant in Europe)

(Here are some fireworks that look a bit like phylogenies! 🎆)

1/23


The latest sequences from 31 Dec show new sequences in the S:N501Y.V1 variant (originating from SE England) from Netherlands, Denmark, Australia, Italy, Canada, the USA, Germany, Switzerland, & India.

2/23

S:N501 link
https://t.co/TfHfPgBEBS

Image link
https://t.co/3aCKv1pAcI


Canada, Germany, & Switzerland all have sequences that fall in 501Y.V1 for the first time, scattered across the tree.

3/23


The USA also has its first 2 sequences that fall in 501Y.V1, from Colorado & California. India also had its first 3 sequences, also from different regions.

In both cases, the sequences are not connected, indicating separate introductions.

4/23


In countries with previous sequences:

6 new sequences from Netherlands, in orange/yellow (green are older).
1 is clearly separate - zooming in (& in divergence view, coloured by country) it is harder to determine the relationship between the others.

5/23

More from World

MISREPRESENTED CONTEXT

1. I am indeed disgusted with attempts to misrepresent and take out of context what I wrote on my blog yesterday.


2. Those who did that highlighted only one part of paragraph 12 which read: “Muslims have a right to be angry and to kill millions of French people for the massacres of the past.”

3. They stopped there and implied that I am promoting the massacre of the French.

4.If they had read d posting in its entirety & especially the subsequent sentence which read: “But by & large the Muslims hv not applied the “eye for an eye” law. Muslims don’t. The French shouldn’t. Instead the French should teach their people to respect other people’s feelings

5. Because of the spin and out of context presentation by those that picked up my posting, reports were made against me and I am accused of promoting violence etc… on Facebook and Twitter.

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