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Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz

 There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20
Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20
Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20
Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20
Ireland has 36 new sequences. Many represent separate introductions, but some do cluster with older sequences & may represent local transmission, or introductions from the same UK diversity.

6/20
Denmark has 29 new sequences (orange). These represent both new introductions, and further expansion of the large cluster (zoomed view).

7/20
The Netherlands have 6 new sequences. All fall within the section of the tree marked in red.
Zooming in, the new sequences are marked in red: 2 are separate introductions. Zooming in further (divergence view), cluster at the top are identical to an older sequence.

8/20
Australia has 6 new sequences, including the first from Northern Territory and Victoria. 1 pair of sequences from Victoria are identical to each other, representing one introduction.

9/20
Spain has 2 new sequences (yellow). One represents a separate introduction. The other links to older Spanish sequences, but it's unclear from sequences alone if this is local transmission or transmissions from a common source.

10/20
Sweden has 2 new sequences, marked in red. Both represent independent introductions. The second one is hard to see, but zooming in shows this more clearly.

11/20
Now turning to 501Y.V2:

There are 4 new non-South African sequences in 501Y.V2, including the first from Ireland (3) and the Netherlands (1).

12/20
Ireland has 3 sequences in 501Y.V2 for the first time. They cluster together, and may indicate either local transmission, or a common exposure (pictures 1 & 2).

The Netherlands has its first sequence in 501Y.V2 (picture 3).

13/20
As usual, the updated country graphs are also available. As always, interpret with care: countries are selectively sequencing to track 501Y.V1, so proportions of sequences are not representative for many countries.

14/20

https://t.co/c7wlQOLRiq
Finally, an updated focal S:E484 build is also up.

S:E484K is found predominantly in the 501Y.V2 variant, & in a cluster of sequences primarily in Brazil, though it has appeared numerous times in the past.

15/20

https://t.co/Od95D6DL74
S:E484K has been discussed recently as there are suggestions it may impact how well the immune system can recognise the virus, particularly if you've been infected with SARS-CoV-2 before.

Links to the studies are on https://t.co/SmanZBHpse

16/20
Additionally, over the weekend, travellers from Brazil to Japan were found to be infected with a novel variant with many mutations, including S:E484K & S:N501Y.
Translated report linked below.

17/20

https://t.co/G1ITeT3MoV
To help viewers identify these new samples from Japan, I've added a *temporarily* label to the S:E484K build: 20B/S.484K.501Y.

Additionally, I've added a *temporary* label to the Brazilian cluster with S:E484K: 20B/S.484K.

18/20
Interestingly, though the recent Japanese sequences carry S:E484K & seem to originate from Brazil, they do *not* branch from the larger 484K cluster in Brazil, but instead sit on a long branch separately within the 20B Clade.

19/20
Getting case numbers down saves #LivesAndLivelihoods, and reduces #SARSCoV2's opportunities to explore situations with unique selection pressures, potentially resulting in mutations expanding that we'd rather not see.

Help make my updates more boring: bring cases down!

20/20
PS - For related but slightly-different-angle updates on 501Y.V1 (B.1.1.7) & 501Y.V2 (B.1.351), you should follow @AineToole & keep an eye on her tweets about updated reports!

https://t.co/fZDQqwvJmr

21/20

More from Dr Emma Hodcroft

Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
🎉Happy New Year!🎉

To kick off 2021, here's an update on:
- S:N501 variants (501Y.V1/V2) with data from 31 Dec 2020
- 69/70del variants
- 20A.EU1 variant (most prevalent variant in Europe)

(Here are some fireworks that look a bit like phylogenies! 🎆)

1/23


The latest sequences from 31 Dec show new sequences in the S:N501Y.V1 variant (originating from SE England) from Netherlands, Denmark, Australia, Italy, Canada, the USA, Germany, Switzerland, & India.

2/23

S:N501 link
https://t.co/TfHfPgBEBS

Image link
https://t.co/3aCKv1pAcI


Canada, Germany, & Switzerland all have sequences that fall in 501Y.V1 for the first time, scattered across the tree.

3/23


The USA also has its first 2 sequences that fall in 501Y.V1, from Colorado & California. India also had its first 3 sequences, also from different regions.

In both cases, the sequences are not connected, indicating separate introductions.

4/23


In countries with previous sequences:

6 new sequences from Netherlands, in orange/yellow (green are older).
1 is clearly separate - zooming in (& in divergence view, coloured by country) it is harder to determine the relationship between the others.

5/23
SOCIETY
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0


There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14


First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14


France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14


Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14
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Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw


There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12


In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12


The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12


Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12
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Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4


There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16


Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16


Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16


Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16
SOCIETY
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL


In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18


Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18


Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18


France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18
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Rosemarie Maughan
Rosemarie Maughan
@Minceirbeoir
I was asked to do a tweet on how to be a good Minceir Ally. So here are my thoughts ... Other Minceiri are welcome to add.
Allies can do the actions you can.

Learn about Traveller Culture, history and issues affecting us from us not others. You can do this by checking Traveller org websites, chat with us, invite us to give inputs in your place of work.

Educate others and challenge Anti Traveller racism when you see it.

Get to know Travellers locally and local issues. Support the work of local and national Traveller orgs.

Get to know Travellers locally becoming friends. Invite Traveller children to your parties/playdates. Let your children go to Traveller children parties,playdates in their home.
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Par!x!t
Par!x!t
@parixit111
A name has caught the radar of agencies investigating #GretaToolkit- FRIEDRICH PIETER. Delhi Police expressed shock over the appearance of Pieter's name as "Who to Follow" in g-doc as he is under cops' scanner since 2006 for his Anti-India activities. Some shocking details..
1/9


Pieter is close associate (read hired by) Bhajan Singh Bhindar, founder of OFMI (Org for Minorities of India) that considers itself an anti-Gandhi 'crusader' & is Pro-Khalistan. They also campaigned to free Bhullar (convicted Khalistani terr0r!st) & lobby against Modi in US.
2/9


Bhinder has alleged connection with ISI & had records of owning inter-state drugs cartel & DVD piracy for terr0r funding. They also took control Fremont Gurudwara, US back in 2003 for millions of donation. Details of this 'Info-War' by @DisinfoLab
https://t.co/oIDFSoaDX2
3/9


Back to Pieter. Take a glance at his work. His TL is filled with anti-BJP/RSS/Modi propaganda. From his speeches to articles, everything have few keywords in common- RSS/Fascism/gen0c!de/k!ll!ing/Kashmir/Hindutva, as if running a non-stop unrest in India is his bread & butter
4/9


He picks every topic with an extreme narrative that potentially hurts integrity of nation, be it Kashmir,CAA,1984 & with his recent projects- Farmer protest & campaigning heavily against Sri Kulkarni. Despite all, Kulkarni appointed as Chief of Ext Affairs at Biden admin.
5/9
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Pepes Army Of Frogs
Pepes Army Of Frogs
@RedWaveWWG1
🔴[RIG FOR RED]
RED 1
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Thread of decodes for the day. Make sure you check out the [SUB] threads too!
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MALUME ZANO
MALUME ZANO
@ZanoUrban
(PART 3) Angels - Izingelosi | Izithunywa of the 1st Sphere 🕯

[A Smallanyana Thread]

On Part 1 and 2, you will notice that we covered Angels that somehow also resemble human physical/ manifested features.

Part of the classic examples of how we as humans always depict these Celestial Beings through our works of art.

As we move up to the 1st Sphere of the Christian Angelology Hierarchy we get introduced to another breed of Izithunywa.

Let's Begin 📖

THRONES:

Also known as the Elders, they are a class of Celestial Beings mentioned by Paul the Apostle in Colossians 1:16, and they are also mentioned in the Book of Revelations as the 24 Elders.

They are the living symbols of God's justice and authority, symbolised as Thrones.

They are also associated with the Ophanim from the Jewish Angelic Hierarchy (Which we will still cover in detail within this series of Threads).

The Ophanim are referenced as Wheels seen in Ezekiel's vision of the Chariot in Ezekiel 1:15 - 21.

Also refer to Elijah's ascension.
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Boz Tchividjian
Boz Tchividjian
@BozT
The evils committed by Ravi Zacharias were enabled by a toxic organizational leadership that is evidenced by how these same leaders responded when confronted about the widespread and ongoing abuses being perpetrated by the namesake of the institution. 1/29

Please take time to read this piece by @DavideAFrench and the 26-page letter written by a first-hand witness. Here are just some of the excerpts: 2/29

"At one point, Ravi suggested to me that the Task Force “issue a statement that they [the Thompsons] are hooligans, they are scoundrels, they are thugs, they are serial extortioners.” If we didn’t do that, he told me, he would ask his attorney to do so on his behalf." 3/29

"...I distinctly recall Ravi & Sanj mocking the Thompsons’ marriage & scornfully predicting how soon Brad & Lori Anne would get divorced. “I predict their marriage won’t survive the year,” Ravi asserted with laughter. “A year?” replied Sanj. “I wouldn’t give it six months!” 4/29

"In 2017, in the early stages of his RICO against the Thompsons, Ravi would often invoke Kelly [his attorney], making statements such as “my attorney said we are going to crush them.”" 5/29
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Share for the benefit of everyone.

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