Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 https://t.co/O7dkEYpndg

Some 1300 years ago in Karnataka there lived a genius who wrote "Gaṇitasārasan̄graha" (which is earliest text devoted entirely to mathematics)

The man who's work later borrowed by Arabs & Europeans

Thread on "Mahāvīracharya" astounding but forgotten legacy

Mahāvirachārya was patronised by rashtrakuta king amoghavarasha

His book"Gaṇita-sāra-saṅgraha"is earliest text devoted entirely to Mathematics

He has described the currently used method of calculating(LCM)of given numbers.The same method was used in Europe later in1500CE

Mahavira wrote "Gaṇita-sāra-saṅgraha" (GSS) in 8th century CE which contains some 1100 slokās & contains elementary topics in arithmetic , algebra , geometry , measurements , logic , number theory , dynamical systems etc

A sheer mathematical genius

He was devout jain
His magnum opus "Ganit sara sangraha " start with a sloka bowing to the glory of the jinas

"संख्याज्ञानप्रदिपेन जैनेंद्रन महत्वेशा,
प्रकाशितम जगतसर्व येन तम प्रणमाम्यहम"

He also praised his predecessor aryabhata , brahmagupta & other greats in his works

The importance & popularity of "Gaṇita-sāra-saṅgraha"was so huge that it enjoyed statues of most important textbook of mathematics in South Indian for over 3 centuries

A large no of manuscript copies of
"Gaṇita-sāra-saṅgraha"whr discovered in Kerala shows it's popularity

JUST IN: The U.S. National Climate Assessment is now public.

This is the report that the Trump Administration doesn’t want you to see. Years in the making, released on the day after Thanksgiving. #ClimateFriday

Here are some of the main

This report is mandated by Congress and focused on the impacts of climate change in the U.S.

Basically: This is what our best scientists think will happen to us as a result of the actions our government is (not) taking to address the most important problem in human history.
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300 experts in 13 federal agencies volunteered their time to make sure you have this information.

Please share it widely.
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The top finding:

“Climate change is projected to significantly affect human health, the economy, and the environment in the United

To expand on that finding:

“In the absence of more significant global mitigation efforts, climate change is projected to impose substantial damages on the U.S. economy, human health, and the environment. ...”
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With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

The Review: GW 23 - A thread

Hi everyone, welcome to the latest edition of “The Review” where me and @urboihamza look ahead to the upcoming double GWs and chip strategies in detail:

#FPL #FPLCommunity @OfficialFPL

(Data taken from @FFScout and @FFH_HQ with consent)

Before I start, an update on the Fantasy5: There have been no winners for two consecutive GWs now, so I feel the organizers have been more sympathetic in setting targets yet again this week. This might be your best chance to win £10k! Link below:

At this point, I’d also like to mention that I post about FPL on my Instagram too, so if you have an Instagram account, do follow up here:

I’d like to dedicate this Review of mine to my dear friend Dylan who is an avid FPL player and a regular reader of my pieces. He is battling a brutal illness so my thoughts are with him and his family during these tough times – stay strong lil bro and good luck!

Q: What is the optimum strategy for FPL managers wildcarding sometime soon who do not have their Free Hit in hand?

I’d like to credit to @BenCrellin for his outstanding work helping to shed more clarity on the double GWs coming up. Southampton winning against Wolves...