MICROBIOME AERODYNAMICS & SEDIMENTATION RATES are studied & known. Who would have guessed that studies would uncover cloud formation & precipitation phenomenon as function of bacteria ubiquity & size.
Falling bacterial communities from the atmosphere | Environmental Microbiome | Full Text https://t.co/sXCeAJ7Ba7
— Laurence Badgley (@BadgleyLaurence) December 11, 2020
More from Laurence Badgley
the prevalence of dancers, gymnasts, and cheerleading is extremely high in the EDS community. :) I was, too. Here's a video, if you're interested, to test yourself with the Beighton scale: https://t.co/Klrh05MKM7
— Christine Clifton (@NoShoutStandOut) November 29, 2020
An experience I have with patients who have stigmata of hypermobility is that I will comment on their widespread joint Hypermobility & their rejoinder commonly is, “of course I do Yoga”.
When patients tell me that my heart sinks. I was excited to tell them that I think that I have an explanation for several of their seemingly disparate symptoms in several of the dysautonomia & MCAS spheres.
Instead, disheartening disappointment takes over as I realize that their yoga devotion has now forestalled my ability to teach them about hypermobility & many attendant dysfunctions they suffer.
When I examine women with hypermobility I sometimes say, “you would be great in yoga”. Often they tell me, “well, that is why I can bend like this, it is because I take yoga”.
You might also be hypermobile, just sayin'... \U0001f609
— Oh TWIST! (@H2OhTwist) December 8, 2020
Another posture that attends unilateral sacroiliac joint disorder in hypermobile people is the Trendelenberg posture. This is to sit flexed forward with elbows on both knees. When brought to their attention, many are apologetic, “I know I shouldn’t slouch”.
The Trendelenberg posture is in fact the wisdom of the body finding the most comfortable position; in this seated bent over position the femurs leverage each sacroiliac joint into an anatomical neutral station; so joint ligaments are not stretched.
Standing posture liked in low back pain due to unilateral sacroiliac joint (SIJ) disorder: keep same-side leg straight & slightly flex knee on stable SIJ side; posture that lowers normal hemi-pelvis down & horizontal with loose sagging side. Body likes horizontal pelvis platform
People with sacroiliac joint (SIJ) disorder sleep restlessly like “rotisserie chicken”, but favored sleeping posture is on the non-subluxing-SIJ side; whereby injured loose SIJ floats upward; better if subluxing-SIJ-side leg is thrown up & over husband, dog, or large body pillow.
Seems like very drastic measures for a very unproven theory.. \U0001f928 Not to mention a lot of this advice would be unsafe or lead to further issues for those with #EhlersDanlos or Hypermobility https://t.co/s88MHnnrRx
— Cortney Gensemer \U0001f52c\U0001f9ec (@CortDoesScience) December 28, 2020
My theory how persons with Fibromyalgia, wasting diseases & severe fatigue should exercise is that they should start with very gentle activities whereat gravity is negated & then through gradations of activities whereby exposure to gravity is gradually increased.
The first phase of exercise for persons with Fibromyalgia & wasting diseases should be similar to what was done with polio in the 1900’s: Warm water relaxes spastic muscles & enables joint range of motion exercises with gravity relatively negated.
During warm water physical therapy, efforts include specific exercises to strengthen muscles supporting a body tower able to stand on land; the goal. Trapezium, Serratus ant., Rhomboids, Rectus abd., Transversus, para-lumbars, Glutes, & all leg muscles must be strengthened.
Once standing on land has been achieved, then moving on land is the next goal. Moving would include crawling & walking. During this phase, people might need extra support of a sacroiliac joint belt &/or perhaps even knee supporters in the beginning. Walking sticks might help.
Have you tried Botox for Migraine? Did it help? https://t.co/a29gDd65mT
— Migraine Again (@MigraineAgain) December 30, 2020
Way to discern spastic unilateral Superior trapezius muscle: look in mirror, view your auto driver license photo, & to pinch leading edge of each Superior trapezius to determine which leading edge is painful to pressure & also thicker; from supporting a chronically tilted head.
Looking in the mirror enables the person to view which shoulder is lower. The head usually tilts toward the lower shoulder side; causing Superior trapezius muscle on the higher shoulder side to be spastic from chronically supporting a tilted head (weighs about 10#).
The drivers license photo often confirms which shoulder is lower and provides clue as to which direction the head usually & chronically tilts. Some people pick a posed posture & straighten up when they pose for a photo. Therefore, other and more candid photos might be examined.
Often, especially in hyper-mobile women, the spine is curved with a functional scoliosis (straightens when reclined), and this is explanation for the asymmetric shoulders and tilted head.
More from Science
If this is true raises the question of why certain (fringe & unethical) views got access to No.10 while others were ignored... https://t.co/A75HrSEqo4
— Prof. Devi Sridhar (@devisridhar) December 13, 2020
I want to talk about 3 things:
‼️Their fringe views are inhumane, unethical junk science that promotes harm
‼️They complain that they've been marginalized but this is simply untrue
‼️I am sick of people telling me we have to "listen to both sides." There aren't 2 sides here 2/n
These 'dissident' scientists have consistently downplayed COVID-19, urging policymakers not to take aggressive control measures. They claim it is not a serious threat. Gupta even went on TV saying people under 65 shouldn't worry about it!
RECEIPTS
They have consistently argued that policymakers should just let the virus rip, in an attempt to reach herd immunity by natural infection. Kuldorff *continues* to argue for this even now that we have many highly effective, safe vaccines.
Focused Protection: The Middle Ground between Lockdowns and "Let-it-rip". An essay by Jay Bhattacharya (@Stanford), @SunetraGupta (@UniofOxford) and @MartinKulldorff (@Harvard). https://t.co/T8uLxSFwgh
— Martin Kulldorff (@MartinKulldorff) December 11, 2020
We've never controlled a deadly, contagious pandemic before by just letting the virus spread, as this approach kills & disables too many people. In Manaus, Brazil, 66% of the city was infected & an astonishing *1 in 500* people died of COVID-19
Simulation: Riding in car for 120 min w/ infected passenger who seems fine other than a cough every few mins. (1) a lot of SARS-CoV-2 virus (in fine aerosol particles) accumulation in car cabin w/ windows closed; (2) cracking window open slightly = dramatic reduction. #COVID19 pic.twitter.com/bCmrmnLUPG
— Dr. Richard Corsi (@CorsIAQ) April 4, 2020
2/ Related air exchange rates were based on experimental results in literature for mid-sized sedans. Particle deposition to indoor surfaces were accounted for, as the surface to volume ratio in a 3 m3 cab is large. An important outcome was the intake fraction (IF)
3/ Here, IF is the number of particles (or virions in collective particles) inhaled by a receptor DIVIDED BY the number or particles (or virions in collective particles) emitted by an infector.
4/ Integrated over the two hour drive (in this example) the IF for all windows closed & a receptor at rest is 0.08 (8% of what comes out of the infectors respiratory system ends up in the respiratory system of the receptor). 8%! That is a very high intake factor.
5/ With additional ventilation from cracking a window open drops the IF to 0.012 (1.2%) still relatively high. Can get lower by opening more windows.
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@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
make products.
"If only someone would tell me how I can get a startup to notice me."
Make Products.
"I guess it's impossible and I'll never break into the industry."
MAKE PRODUCTS.
Courtesy of @edbrisson's wonderful thread on breaking into comics – https://t.co/TgNblNSCBj – here is why the same applies to Product Management, too.
"I really want to break into comics"
— Ed Brisson (@edbrisson) December 4, 2018
make comics.
"If only someone would tell me how I can get an editor to notice me."
Make Comics.
"I guess it's impossible and I'll never break into the industry."
MAKE COMICS.
There is no better way of learning the craft of product, or proving your potential to employers, than just doing it.
You do not need anybody's permission. We don't have diplomas, nor doctorates. We can barely agree on a single standard of what a Product Manager is supposed to do.
But – there is at least one blindingly obvious industry consensus – a Product Manager makes Products.
And they don't need to be kept at the exact right temperature, given endless resource, or carefully protected in order to do this.
They find their own way.