BC SCIENCE
Saved by @Alex1Powell

@I_Make_It_All One approach that i have found that works, is to work out how you can make a new tool pay for itself.

After that point, it's yours, free and clear. :)

 @BillieRubenMake @I_Make_It_All We came up with this when i was talking with one Hackney Punk that was running a video projector and lighting rig.

He was complaining about how he had hired his video projector out for a party, and it had come back with one of the lenses missing.
@BillieRubenMake @I_Make_It_All Apart from the rudeness of the person that he had hired the projector to, he was saying that he was tired of dealing with the logistics of the hires, when he just wanted to use the projector for his art.

This was his original reason for buying the machine.
@BillieRubenMake @I_Make_It_All I asked him how much the projector had cost, how many times he had hired it out, and, how much he had been paid for the hires.

He hadn't thought about it, so he started scribbling down some figures.
@BillieRubenMake @I_Make_It_All When he totalled up the amounts, he realised that the projector had cost him around £1200, and had been hired out for a total of £1350, so it was paid for. :D

He didn't NEED to hire it out again.

He could afford to say No to annoying customers. :D
@BillieRubenMake @I_Make_It_All More importantly, he could just use it for his own art, which is why he bought the damned thing in the first place. :D
@BillieRubenMake @I_Make_It_All So rather than being depressed over annoying clients, he was happy that he didn't have to deal with them again. :D
@BillieRubenMake @I_Make_It_All I've use this approach myself, when buying equipment.

I'll find ways of making the hardware pay for itself, then after that it's mine to use as i wish. :D
@BillieRubenMake @I_Make_It_All There are some contracts i would take on, specifically to pay for the equipment that i would need to do the tasks. :D

Everything after that is a bonus. :D
@BillieRubenMake @I_Make_It_All I'm applying this approach to ALL of the hardware that i work on.

Every machine i work on, should be able to pay for itself, and as long as that the time taken to do that, is a fraction of the machine's rated lifespan, then it's a profitable purchase. :D
@BillieRubenMake @I_Make_It_All One of the wind-turbine designs is made using bicycle components, as it's an existing supply-chain operating to a known standard.

It'll pay for itself in 24-36 months, but with maintenance, it'll last for 50 years. :D
@BillieRubenMake @I_Make_It_All And as the design is taken from 16th-17th Century designs, it's completely unencumbered by patents. :D

Once the first 3 years are done, it's free for the next 47 years. :D
@BillieRubenMake @I_Make_It_All I apply this approach to every machine that you use.

How long will it last?

How much does it cost?

How long till i make my original money back?

After that i don't need to hire it out. :D
@BillieRubenMake @I_Make_It_All Sorry, that should have said, "Every machine that i use".
@BillieRubenMake @I_Make_It_All @threadreaderapp
@BillieRubenMake @I_Make_It_All @threadreaderapp @threadreaderapp unroll

More from Science

NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
Localized Surface Plasmon Resonance - an overview | ScienceDirect Topics

https://t.co/mzS7vVSREJ

https://t.co/353PdAX2fa

https://t.co/3yBImjOdd4

In some cases, almost 100% of the light energy can be converted to the second harmonic frequency. These cases typically involve intense pulsed laser beams passing through large crystals, and careful alignment to obtain phase matching.
SCIENCE
Michael Lin, PhD-MD
Michael Lin, PhD-MD
@michaelzlin
Fellow academics, when are we going to start fixing our urgent structural problems that strain family bonds and present ongoing barriers to diversifying our educational and scientific leadership? You wonder, what the heck is this guy talking about?
1/n

We’re all very familiar what I am talking about, actually: the impossibility for most academics in the life sciences to do their jobs in a reaonable amount of time, due to more and more demands on writing grants, and to a lesser degree, papers.
2/n

As of yesterday I hadn’t intended to write about this subject, but was wondering as I finished a Saturday of straight work, what happened to all my time? Why has WFH not reduced my pile of tasks to do? Instead why is my to-do list growing bigger and bigger?
3/n

I decided to figure out how much time our jobs actually require. I estimated per year (m=month, w=week, d=day, h=hour):
Teaching: 20h/w x 20w = 400h
Meetings of all sorts: 10h/w x 48w= 480h
Replying to email: 2h/d x 365d = 730h
Attending and giving talks: 2h/w x 50w = 100h
4/n

Papers: If each person needs 2 papers during a 5y stint, and you run a 7.5-person lab, then you need 7.5 papers per 2.5y = 3 papers/y. Throw in a review and it’s 4 papers. If you need 15d at 8h/d per paper, that’s 480h writing papers.
5/n
SCIENCE
Advertisement
Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Let Uncle Ralph educate you
Synthetic Viral Genomics:
Risks and Benefits for Science and Society

"Alternatively, “No See’m” sites can be used to insert foreign genes into viral, eukaryotic, or microbial genome or vector, simultaneously removing all evidence of the restriction sites that were used in the recombinant DNA manipulation"

By orientating the restriction sites as “No See’m”, the sites are removed during reassembly, leaving only the desired mutation in the final DNA product.

The dual properties of strand specificity & a variable end overhang that can be tailored to match any sequence allow for Esp3I sites to be engineered as “universal connectors” that can be joined with any other four nucleotide restriction site overhangs (e.g. EcoRI, PstX1, BamH1)

Seamless assembly (also called No See’m Sites (85)) cascades have been used to assemble full length cDNAs of the coronaviruses mouse hepatitis virus, transmissible gastroenteritis virus, infectious bronchitis virus and SARS-CoV (Refs: 85,86,87)
SCIENCE , ALL
Wonder of Science
Wonder of Science
@wonderofscience
These 'Beach Animals' were created by Theo Jansen as a fusion of art and engineering. The kinetic structures walk on their own and get all their energy from the


Watch the full video on Youtube:
SCIENCE
Smit Patel
Smit Patel
@snazzysmit
Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval


⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.
SCIENCE

You May Also Like

Jaya_Upadhyaya
Jaya_Upadhyaya
@Jayalko1
SRI KUMARIAMMAN, KANYAKUMARI (TN)
#bharatmandir #navratri2021

Created by Maharshi Parasurama and also one among the 108 Shakthi Peethas in the world. The name Kanyakumari stands for Kanya(Virgin) and Kumari(girl).
Devi took this form to vanquish the demon Banasura
@GunduHuDuGa


Once, Banasura(grand son of Mahabali) obtained a boon from Shiva that he could be vanquished only by a virgin.
So, Devi took the form of a kumari and started meditating with the desire to marry Shiva at Suchindram.
Pleased Shiva fixed the midnight hour for marriage with Devi.


Devarshi Narada knew that the marriage would end the chance of killing Banasura. So, he assumed the form of a cock and crowed. Shiva returned back to Suchindram thinking that it was dawn.
Angered, Devi cursed that all food and articles meant for wedding turn into sand and shells


When Banasura heard about Devi’s beauty, he tried to take her by force. Devi, then, killed him and granted the wish of Devas to remain there always protecting them.
The murti of Devi stands with a rosary in hand. Her diamond nose-ring is said to be visible even from the sea.


Once an ancient mariner mistook it for a lighthouse and sailing towards it, his ship wrecked upon the Kanya Kumari rocks. In order to prevent such a tragedy from happening again, the eastern door of the shrine is opened only on five special occasions throughout the year.
ALL
Patrick McKenzie
Patrick McKenzie
@patio11
Most software founders, particularly in B2B, need to get radically better at sales. @Steli , who is the best person for explaining the scrappy stages in the beginning and then building out a team with scripts and processes, wrote a guide to:

For technical founders it is irrationally, obscenely hard to reverse years of programming (ba dum bum) that sales is a value-destroying activity. Sales is CLEARLY a value-creating activity, contingent on you have a value-creating product.

The world will not drop what they are doing to adopt your work. This is particularly true in B2B, where simply building a better mousetrap won't overcome the activation energy required to get people with additional non-mice problems to prioritize changing mousetraps today.

This is very non-obvious for founders because founders are not often people who *want* to be sold to. We often come from a background where trying out tools is a bit of a fun hobby. We like looking at all the options, making charts, and ripping out partially complete tests.

"This week I unsuccessfully trialed four software options for automating that thing that has been killing us. Our actual production process remains the same as last week. Don't worry; this was a great use of time." is not a thing you want to write in a progress report to manager.
TECH
Advertisement
Reagan Gomez
Reagan Gomez
@ReaganGomez
Black movie goers know which movies are for us and which films aren’t. We really don’t like our stories being made into films that center (and humanize) people that hate us. The filmmakers/studio know that by naming the film “The Green Book”, black movie goers...

...are going to be expecting a story about black people trying to safely navigate the country (real history) and instead will get a white savior film. Like folks went to see Detroit thinking it was about the riots...

Anywhoo, I know Mahershela is fantastic in it. He was the best thing about the trailer. As rich as the history behind the creation of ‘The Green Book’ is/was, as amazing as Dr. Don Shirley’s story is, WHY is this film about a random, racist driver and his family?

This feeds into the ignorant anti-Black American stereotype of “Black Americans don’t have any culture/history/mythology” or whatever. That our stories are still both being used while simultaneously erased in 2018 is wild to me. It’s gonna clean up come award season. 🤦🏾‍♀️

And now, if black filmmakers WANTED to make a film about The Greenbook, guess what it can’t be called🙃. Just like if someone wanted to make a film about the actual Detroit riots, guess what it can’t be called? Then those filmmakers would run into...
CULTURE
Learning @ Prakash
Learning @ Prakash
@Prakashplutus
My simple Approach towards Breakout trading :

1. Scan stocks on the basis of FTDB Scanner.

2. Buy stocks with EMA-9> EMA-21> EMA-63 > EMA 200 & Volume 200% up

3. maximum SL of 1.25X ( ATR )

4. I do breakout trading only in Nifty -500 stocks

#StockMarket
#trading
#Nifty
SCREENERS
Andrew Chen
Andrew Chen
@andrewchen
1/ new essay: What's next for marketplace startups? Reinventing the $10 trillion service economy, that's what. Co-authored with @ljin18 https://t.co/fgKbrHTnH5. A short thread 👇

2/ Marketplace startups have done incredibly well over the first few decades of the internet, reinventing the way we shop for goods, but have been less successful services. It's bc services are complex, subjective, fragmented, and often in real life. Makes it hard

3/ There's been 4 major eras at making the service economy work online. The Listings Era, the unbundled Craiglist era, the Uber for X era, and the Managed Marketplace era


4/ Each era has added more value than the last, and utilized technology innovations, from internet to social / "read/write web" to mobile. The "Unbundling Craigslist" era was particularly epic at generating startup ideas


5/ The problem is, all the low-hanging fruit has been picked off. The techniques that got us to here won't get us to the next phase. So we have to do some pretty different things. That's why "Managed Marketplaces" have been a big deal - hire folks as W-2s, certify quality, etc.
STARTUPS