is an excellent scientist and a responsible professional. She likely read the paper more carefully than most. She grasped some of its strengths and weaknesses that are not apparent from a cursory glance. Below, I will mention a few points some may have missed.
1/

The paper does NOT evaluate the effect of school closures. Instead it conflates all ‘educational settings' into a single category, which includes universities.
2/
The paper primarily evaluates data from March and April 2020. The article is not particularly clear about this limitation, but the information can be found in the hefty supplementary material.
3/
The authors applied four different regression methods (some fancier than others) to the same data. The outcomes of the different regression models are correlated (enough to reach statistical significance), but they vary a lot. (heat map on the right below).
4/
The effect of individual interventions is extremely difficult to disentangle as the authors stress themselves. There is a very large number of interventions considered and the model was run on 49 countries and 26 US States (and not >200 countries).
5/
It is challenging to estimate the effect of interventions in the absence of a counterfactual. This difficulty is compounded by likely confounders, such as climate (not mentioned in the paper). Territories that implemented similar interventions might share comparable climate.
6/
This is a sophisticated piece of work, with both strengths and weaknesses. Though, to me, its primary value is the proposed methodological framework rather than its estimates of the efficacy of individual interventions, which efficacy remain debatable.
7/
There is room for scientific discussion about how solid the estimates presented in the paper may be. Though, accusing colleagues expressing reservations about the robustness of some of the findings of 'spreading disinformation' feels inadequate, to say the least.
8/
This paper has generated endless conflict. One intriguing feature is that all the spats are around 'educational settings'. Interestingly, the paper also claims that T&T and isolation of cases, among other measures, are completely ineffective, yet no one seems to care ... 🤔
9/

More from Science

I want to share my thoughts, as someone who has been so alarmed by the so-called "dissident" scientists like Gupta, Heneghan, Kuldorff, Bhattacharya, & Ioannidis who consider themselves brave Galileos unfairly treated by "establishment scientists." I will try not to swear. 1/n


I want to talk about 3 things:
‼️Their fringe views are inhumane, unethical junk science that promotes harm
‼️They complain that they've been marginalized but this is simply untrue
‼️I am sick of people telling me we have to "listen to both sides." There aren't 2 sides here 2/n

These 'dissident' scientists have consistently downplayed COVID-19, urging policymakers not to take aggressive control measures. They claim it is not a serious threat. Gupta even went on TV saying people under 65 shouldn't worry about it!

RECEIPTS

They have consistently argued that policymakers should just let the virus rip, in an attempt to reach herd immunity by natural infection. Kuldorff *continues* to argue for this even now that we have many highly effective, safe vaccines.


We've never controlled a deadly, contagious pandemic before by just letting the virus spread, as this approach kills & disables too many people. In Manaus, Brazil, 66% of the city was infected & an astonishing *1 in 500* people died of COVID-19
Read this thread from @lilithsaintcrow. I really mean it. Just read it. Because if what she is saying is true (and I happen to think it is) it explains *so much*

An example using the Flat Earthers: A thread of many parts:


I'm firmly convinced that the flat Earth thing was started by some adolescent trolls with nothing more productive to do. They didn't believe it, but they thought it was entertaining to keep pretending that they did.

You can't engage with them, because they *are playing a game*. They think it's fun to see if they can get anybody to engage with something completely stupid as though it's true.

If you challenge them, the rules of the game state that they have to argue as hard and a spuriously as they like, but *never* to admit that the Earth is not in fact flat. I suppose you have to make up your own entertainment on 4chan or whatever hole this was conceived in.

It's annoying as hell, but I suppose it doesn't do much harm.. except to folks like this:

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