BC HEALTH
Saved by @Alex1Powell

[Thread]: Old school "medicine" ads obviously created by aliens.

Let's begin with cocaine toothache drops, for only 15 cents.

 Dr. Batty’s asthma cigarettes were not recommended for "children under 6.”
Best prescription for malaria, chills and fever: Grove's tasteless Chill Tonic, obviously.

"It is simply iron and Quinine in a tasteless form".
The cheapest specific for the relief of cough: heroin.
There's also Dr Williams' Pink Pills for Pale People.
Headache? Drink a bottle of Coca Cola.

ITS PURITY IS PROVED BY ANALYSIS.
It only contains "menthol, cocaine, red gum, eucalyptus, guaiacum, rhatany, potash, borax, formaldehyde and cinnamon oil"
Hunt's Remedy - the great kidney & liver medicine. Never known to fail.
Compound Cream of Ammonia removes that tired feeling in your morning bath and also cleans culinary utensils.

Don't forget to use it when you need to clean and restore color to the carpet.
The Sparklet Nasal completely cures head colds.
Malt Bitters - the purest and best medicine in the world for nourishing and strengthening and for overcoming dyspepsia, debility and wasting diseases.
Merchant's Garglin Oil is the standard, Liniment of the United States and is good for burns, scalds, rheumatism, flesh wounds, sprains, bruises, lame back, hemorrhoids, toothache, sore throad, chapped hands and many other diseases.
Dr. Hand's Remedies for Children: mothers, use Dr. Hand's Colic Cure in place of stupefying syrups, paregoric, and cordials. Immediate relief for wind colic or crying babies. Not injurious.

The cat in a dress skipping rope is important.
Dysentery? Take Dr. Morse's Magic Pills. Cats are not included.
A cocaine suppository to cure uterine, rectal and urethral diseases.
Is "Smoker's Fag" beginning to get you?
The most popular agent. Compound Oxygen: its mode of action and results, a treatise of nearly two hundred pages, giving full and interesting information is mailed free to every applicant.
https://t.co/1BFxQ542KI
https://t.co/onqTwNIb2i
I'm concerned about the mental health of those who designed this

More from Marina Amaral

Marina Amaral
Marina Amaral
@marinamaral2
During the late 19th century and the early 20th century freak shows were at their height of popularity; the period 1840s through to the 1940s saw the organized for-profit exhibition of people with physical, mental or behavioral disabilities.


The Jaramillo sisters Natalia (b. 1889) and Aurora (b. 1896) were from Albuquerque, New Mexico.


Stephan Bibrowsky (1890-1932), known as Lionel the Lion-Faced Man (due to a rare condition called hypertrichosis).


“Ladies and gentlemen … I would like to introduce Mr. Joseph Merrick, the Elephant Man. Before doing so I ask you please to prepare yourselves—Brace yourselves up to witness one who is probably the most remarkable human being ever to draw the breath of life.”


Lazarus and Joannes were Italian conjoined twins who toured Europe during the 17th century.
HISTORY
Marina Amaral
Marina Amaral
@marinamaral2
Rio de Janeiro, 1920. 🇧🇷


São Paulo, 1910. 🇧🇷


“Arpoador”, Rio de Janeiro, 1900. 🇧🇷


“Avenida Paulista”, São Paulo, 1902. 🇧🇷


Recife, 1885. 🇧🇷
HISTORY
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Marina Amaral
Marina Amaral
@marinamaral2
And since today is International Day of Women and Girls in Science, let's highlight a few of them - just a few women among thousands of others who helped shape the world we live in today.

Thread.


Dorothy Hodgkin discovered the structure of insulin after 36 years of work.

"I was captured for life by chemistry and by crystals."


Sophia Jex-Blake fought for women's rights to study medicine. She was involved in founding two medical schools for women.

"It seemed discreditable to Great Britain that all her daughters who desired a University education should be driven abroad to seek it."


Alice Augusta Ball developed the "Ball Method", the most effective treatment for leprosy during the early 20th century. She was 23.


Ada Lovelace is regarded as the first to recognize the full potential of computers and as one of the first computer programmers.

“That brain of mine is something more than merely mortal; as time will show.”
SOCIETY , SCIENCE
Marina Amaral
Marina Amaral
@marinamaral2
Best non-fiction books you’ve read on womanhood?
BOOKS
Marina Amaral
Marina Amaral
@marinamaral2
[THREAD]

Okay. How do I explain what happened yesterday?

Colorizing photos is a lonely process. Before I even begin the colorization itself, I spend hours – or even days – reading, researching, studying, and finding stories. /1


It is time-consuming, sometimes emotionally draining, but just as enjoyable.

My work gave me the opportunity to meet incredible people: teachers, renowned historians, authors; and some became close friends.

But... /2

... even though all these encounters mean a lot to me, none of them are or were able to prepare me for the moments when I have the opportunity to talk to relatives of people portrayed in the photos that I colorized. /3

It is as if those “historical personalities” – strangers who become so close to me, in a weird way, since I spend so many hours in “their company”, restoring and applying colors to their faded photos – jump off the screen and materialize in front of me. /4

I cannot describe the feeling. This is what happened when Frank Garahan, son of Captain Thomas H. Garahan – portrayed in one of the dozens of World War II photos that I restored over the years, and which soon became one of my favorites – got in touch via Twitter. /5
FOR LATER READ

More from Health

The Tycoon Mindset
The Tycoon Mindset
@tycoonmindset05
APL Apollo conducted their earnings con-call today at 2:00 pm

"Vision of capacity of 4 Million Tone till 2025"

@hiddengemsindia @gvkreddi

Here are the key highlights 😀👇

Business Updates:

• Net Working Capital Remains under 10 days which is best in the building material
• Continue expanding rural region.
• Added 15 new distributors.
• Value added products contributed 50-60% of the topline.

Revenue breakup


• EBIDTA Margin Improvement: This was mainly because of cost structarize and better operational

• Working Capital Cycle as per mgmt should remain sustainable

• Blue Ocean: Company owns 100% subsidiary which contributes nothing but own property where corporate office is there

Improvement in Net Selling Realization:
• With expanding capacities at 2.6Million Tones and utlization of 75%, scalability has been affected.
• While the prices of steel has gone by by around 35%, due to shortage of steel.

• Apl Apollo being the dominant player past connection with steel companies worked well.
• Steel tubes supply from China is shrinking.
• Hence the discounting factor while selling the products has went away.
HEALTH
Noah Sasson
Noah Sasson
@Noahsasson
Before we get too far into 2021, I thought I’d write a thread recapping some of the research that came out of my lab in 2020. Most of this work was led by my talented team of graduate students, Kerrianne Morrison, @kmdebrabander, and @DesiRJones.

Back in January, a news story was published about Kerrianne’s study showing improved social interaction outcomes for autistic adults when paired with another autistic partner.

A detailed thread about the study and a link to the paper can be found here (feel free to DM me your email address if you’d like a copy of the full paper for this study or any of our studies):


Another paper published early in 2020 (it appeared a few months earlier online) showed that traditional standalone tasks of social cognition are less predictive of functional and social skills among autistic adults than commonly assumed in autism research.


Next, @kmdebrabander led and published an innovative study about how well autistic and non-autistic adults can predict their own cognitive and social cognitive performance.
HEALTH
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Dr Catherine Pemble is #SocialDistancing
Dr Catherine Pemble is...
@CatherinePemble
Right, screw it. Here's a thread on *that* FBLive by Alex Cairnie about #Govanhill. Lets do a watch-through shall we? (Mind, I'm a resident of Govanhill, and a sociologist. I'm also 5'3, and a visibly queer woman so if half his claims are true I should be living in terror)

00:30: Welcomes viewers and uses points out that his videos are only getting attention b/c they're 'horrific'. Directs folk to his Youtube page. So already clout hunting.

1:08: "I've been warned to stay out of Govanhill. I'm a marked man" (proceeds to use a beanie as a disguise)

1:30 "Laughing and joking aside, here's somebodys front garden." Proceeds to show litter and claim its thrown from windows and this is 'common'. I know a handful of streets with litter issues like this, but its neither common nor unique to #govanhill and other deprived areas.

2:10 "Don't be under any illusion I'm only showing you the bad bits" - only shows you the bad bits.

3:45: He's had offers of help, but hes said no because hes not responsible for 'anybody elses safety' Good lord.

5:01: "Its not that bad. But its not all good either" -Correct

6:00: TW: child abuse - He starts claiming to have been contacted by a health professional and told about child abuse 'in the area'. Huge ethical issues here as the 'professional' who has 'been in the game a long time' is reporting to Facebook Dude and not authorities.
HEALTH
AutisticSciencePerson
AutisticSciencePerson
@AutSciPerson
Okay, let's start this hypersomnia thread!

[note - I am not looking for unsolicited advice.]

Idiopathic hypersomnia or narcolepsy (not the same, but similar) is very hard to describe to people.

When I say "I slept 10 hours last night and I'm still tired" I'm not bragging. 1/16

For me, the accommodations I need are about time. My body doesn't care what I want to do - when I want to wake up or be asleep. My body wants to wake up at 10-11am, and go to sleep at 3am, always.

Just a one hour shift in my sleep schedule can screw me up for days. 2/16

When I tell people that I'd really "prefer it" if we could meet at 10am or later, it's because getting up before that has consequences for me. Big consequences. Most people won't see them. Sometimes I still give in and say it's fine. It ruins 2-3 of my days, sometimes more. 3/16

Let me explain. When I am required to wake up at 9am, esp. in covid times working from home, my body pays me back for it later.

I'm going to show you ways this happens. I can usually withstand 1 day of waking up early, with some consequences, but 2 days in a row kills me. 4/16

Let's say this graph represents Day 1, the first time I am required to get up early. The y-axis is my level of Sleepiness. Any symptom listed higher up includes that symptom + every other symptom below it. Getting up that early means I can't listen or concentrate all day. 5/16
HEALTH
Avraham Z. Cooper, MD
Avraham Z. Cooper, MD
@AvrahamCooperMD
1/15
Why can cefepime cause neurological toxicity?

And why is renal failure the main risk factor for this complication?

The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.

#MedTwitter #Tweetorial


2/
Let's establish a few facts about cefepime:

🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)

https://t.co/rjYG1BfGPR


3/
The first report of cefepime neurotoxicity was in 1999.

A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.

✅All symptoms resolved after hemodialysis.

https://t.co/u7JLVitQpp


4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).

💡The main risk factors = renal failure and lack of dose adjustment for renal function.

https://t.co/nxbnzSq8AR


5/
What about cefepime induces neurotoxicity?

One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.

This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).

https://t.co/Lf4BhON9IY
HEALTH

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Suhas S. Hardutt
Suhas S. Hardutt
@HarduttSuhas
THE BATTLE OF SARAIGHAT (1671)

Lachit Borphukan's humiliation of Aurangzeb.

The battle of Saraighat was a naval engagement fought on the Brahmaputra river near Saraighat between the M0ghul empire and Ahom kingdom in 1671.

Guts, resolve and glory!

(Elaborate thread)


Koch was a state situated between the dominions of M0ghuls and Ahoms. For Ahoms, it was a buffer state for keeping M0ghul territorial expansions at bay.(1)

Times changed when the ruler of the Koch kingdom, Nara Narayana passed away in 1587 resulting in Koch being divided into 2. Western Koch was ruled by his son Lakshmi Narayan and the eastern Koch by his nephew, Raghudev.(2)

Lakshmi Narayan formed an alliance with M0ghuls after which he attacked Parikshit, son of Raghudev, in 1602. Parikshit Narayan was defeated while his brother Bali Narayan took refuge in the Ahom Kingdom.(3)

The M0ghuls used it as a pretext to invade Ahom kingdom. The first battle between them took place in 1615 leading to a series of engagements in which both sides had their shares of ups and downs resulting in a stalemate.(4)
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Ramsay Rippers \U0001f354
Ramsay Rippers 🍔...
@RamsayRippers
🧵EMA + VWAP STRATEGY

Every trader has a go-to strategy that works best for them. My trading is all about keeping it simple stupid and revolves around two indicators - Exponential moving averages and vwap.

Here's the strategy that I utilize on nearly 80% of my trades.

👇

What are Exponential Moving Averages?

EMA's are a type of moving average that places a greater weight on more recent data points.

8EMA = Exponential Moving Averages of the last 8 candle closing prices.

EMA's adjust with respect to chart time frame.

What is VWAP?

Volume Weighted Average Price - A key intraday indicator in my trading that offers the true average price based on price & volume.

Calculation: (Price x # of shares traded) / total shares traded

EMA's I use

- 8
- 21
- 50

While I do utilize the 50EMA, the 8 & 21 EMA are most important for this strategy. Some people use the 9 and 20 which are essentially the same thing. REMEMBER: EMA'S adjust with respect to time frames.

A+ Set Up Criteria - (What I look for)
STRATEGY
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Patrick McKenzie
Patrick McKenzie
@patio11
A thread on HN about bad code in legacy projects both makes me think how little we've learned as a discipline over the years and, honestly, how little credit we give ourselves for some pretty major

Fun going down this list and thinking: "Hmm, plausible at a well-run modern software shop", "Hmm, possible, but requires implausible tradeoffs", "Literally disallowed by languages", and "If you were to attempt doing that our test suite wouldn't let you merge."

I think we as an industry celebrate (not quite the right word) failure too much and don't celebrate success nearly enough. There is no DailyWTF for competent execution, word of which generally stays pretty local to the source while incompetence passes into legend.

Alrighty let me try to thread the needle on being the change I want to see in the world while not giving away anything that will get me in trouble:

Ruby has wonderful developer ergonomics. Typed languages are easier for machines to guarantee the correctness of. We built a type checker for Ruby (and I believe it is slated for OSS release sometime).

c.f.
TECH
Lu_lu\U0001f498
Lu_lu💘
@luciame16
Some thoughts on episode 54 of #Hercai

If you ever cross the distance and come to me, come with love that blooms in your heart.
~ Şems-i Tebrizi

#Reyyan #Miran #ReyMir #EbruŞahin #AkınAkınözü
#HercaiThoughts


1
I have to make a note before writing about this episode. I was the person (still am) who thinks that bringing back D. was a bad idea. I repeat it that for me the writing of S1 and S2 is like tossed into the bin with that plot evolution, but they had to invent something+
#Hercai

2
+ to be able to continue to prolong the general story after Aslan’s story did not work out. All the suffering of M., all the crying seems for “nothing” for two seasons and we viewers are also kind of fed up in seeing him cry all the time when with the upcoming episodes+
#Hercai

3
+he is justified the most to cry. With her resurrection now the attention shifts back to Miran’s storyline and I don’t know if I like this to be honest. This said, Dilsha is here and we have to deal with her.
#Hercai

4
So, my comments are going to be how I find they wrote her into the story, the details we get to know, the flashbacks we get to see, the way it was filmed and directed, with leaving out if I agree on it or not but describing along the way what I saw.
#Hercai
CULTURE
Janmajit Sinha
Janmajit Sinha
@Impregnable007
#Thread - 1/21

A story of a brave woman who let her "breast" cut to protect the life of Netaji Subhash Chandra Bose!

Neera Arya was born on March 5 1902 in Khekra Nagar, Uttar Pradesh in a distinguished & eminent businessman Seth Chhajumal's family. Since her childhood,


2/21
She was a true nationalist & always had a vision of becoming a part of the freedom fighter movement. She was also reportedly accused as an undercover by the British Govt.

That was the time when her father's business was flourishing in Calcutta, though his business was..

3/21
spread across the country but Calcutta was the center of his business and that was one of the reasons why her education was done in Calcutta. During that period of time, she had learned quite a few languages along with Bengali, Hindi, English.

4/21
Her father got her married to a CID Inspector "Shrikant Jairanjan Das" in British India but they were two different individuals, Neera Arya was a true nationalist but her husband was a true British servant. She was highly motivated & she had an urge of getting us freedom..

5/21
so she ended up joining the Jhansi Regiment in Azad Hind Fauz after the marriage. It was the regiment that the British always accused them of spying on British Govt.

It was the time when Neera's husband Jairanjan Das was given the responsibility to spy on Netaji Subhash..
CULTURE