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"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."

"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."

"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."

"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."

"However, it is the active form of vitamin D, 1,25(OH)2D, that interacts specifically with the vitamin D receptor (VDR) and transacts gene expression."

"Those men with the highest compared to lowest 1,25(OH)2D and activation ratios are more likely to possess butyrate-producing bacteria that are associated with favorable gut microbial health."

"25(OH)D levels vary with site and sun exposure, but 1,25(OH)2D levels do not follow this association."

"the serum 1,25(OH)2D was the factor that explained the highest proportion of the variance in α-diversity (e.g., bacterial species diversity within an individual) at just over 5%"

"Greater α-diversity [gut bacterial species diversity] is associated with higher 1,25(OH)2D levels and larger vitamin D activation and catabolism ratios."

"Overall, apart from known correlates such as race and geographic locations, measures of vitamin D metabolic flux were remarkably associated with microbial β-diversity"

"We report robust correlations between the vitamin D metabolites, 1,25(OH)2D and 24,25(OH)2D, and the gut microbiome in 567 older men representing six geographic sites across the United States"

"Those men with higher levels of 1,25(OH)2D had greater α-diversity, even after adjusting for previously characterized determinants of microbial diversity including age, geographical origin, race, PPI, and antibiotic use."

"Serum 25(OH)D is the preferred clinical measure because it is representative of overall body stores of vit D; however, our results suggest it is the regulation of VDM, reflected by active hormone & metabolic ratios rather than body stores that have the most health implications."

"The positive association between diversity metrics and vitamin D activation and catabolism ratios suggests that physiologically normal vitamin D flux is more likely to occur in individuals with healthy microbiomes."

"In summary, we provide strong evidence of important interactions between host vitamin D signaling and the health of the gut microbiome in older men."

More from Robin Monotti FRSA ⭐

Robin Monotti Graziade...
@robinmonotti

LIST OF QUESTIONS FOR MPS
From @ClareCraigPath and Dr Jonathan Engler:
.
1.Why are SARS-CoV-2 antibody levels flat or dropping across all age groups since May if the pandemic is still going?

2.What percentage of the population is assumed to have had prior immunity to SARS-CoV-2 in the SAGE forecasting models?

3.Why do 50% of household members not catch SARS-CoV-2 from infected persons with whom they live?

4.Why have Japan and South Korea not had any serious outbreak if the human species has no prior immunity to SARS-CoV-2?

5.What percentage of the population of the UK is assumed to be immune to COVID-19 (including prior immunity) as of this date?

Robin Monotti
@robinmonotti

You know why they didn't try anything like this in the 1970s? Because a generation which remembered WW2 & were still strong enough would not have let them. Politicians were scared of people's reactions back then. They were literally scared for their lives. What happened?

Also, the State did not simply consist of politicians backed by a few regime journalists. There was a much stronger judiciary & military. We would already have seen the military remove deranged politicians leading any country into ruin like this.

The military would have turned against any government which indicated their role was to swab violate children or help inject people with unsafe experimental RNA altering drugs for a virus with a 99.7+% survival rate. They would have taken power by now. What happened?

The most important lesson we can teach our children are the lessons the parents who remembered WW2 taught theirs: how to say NO to a government that is going in a direction you disagree with before it's too late.

This has to start at refusing schools being turned into biosecurity propaganda outposts, asymptomatic testing stations, anti-science brainwashing institutions on masks, repeated swab violation of children's bodies for no gain & to artificially create false positive disruption

Robin Monotti
@robinmonotti

WHY MASKS DON'T WORK:
Coughing is NOT the issue.
Large droplets are NOT the issue. Breathing exhales MUCH MORE virus in fine aerosols than coughing. Finer aerosols bypass masks/nose & reach the lungs. Masks NEBULIZE. Solution is VENTILATION not face masks.
https://t.co/FMqYszHKVt

"Once direct measurement of particles containing viruses in exhaled breath was technically feasible, most particles (87%) with influenza viral RNA were found to be smaller than 1 μm."

"Influenza viral RNA was detected in the exhaled breath of 92% of adults. The fine particles contained 8·8-times more viral copies than did the coarse ones. Respiratory viruses have been found in both coughs (82% of participants) and exhaled breath (81% of participants)"

👉 "Human rhinovirus was collected more frequently in exhaled breath than in cough aerosols using a filter method." 👈

"The Middle East Respiratory Syndrome (MERS) coronavirus was isolated from seven room air samples from dedicated MERS units in two South Korean hospitals. All seven were positive by PCR and four of seven were positive on viral culture."

Robin Monotti
@robinmonotti

I have now re-examined this document:

On the 19th March 2020 the WHO released this guidance intended for healthcare workers (HCWs), healthcare managers and IPC teams at the facility level & at national and district/provincial level:https://t.co/C4aV2BnMPj pic.twitter.com/tCk1EyLskV
— Robin Monotti (@robinmonotti) December 21, 2020

It clearly does indicate both the risks of bacterial infection & to prescribe broad spectrum antibiotics as part of treatment:
"Collect blood cultures for bacteria that cause pneumonia and sepsis, ideally before antimicrobial therapy. DO NOT
delay antimicrobial therapy"

"6. Management of severe COVID-19: treatment of co-infections
Give empiric antimicrobials [broad spectrum antibiotics] to treat all likely pathogens causing SARI and sepsis as soon as possible, within 1 hour
of initial assessment for patients with sepsis."

"Empiric antibiotic treatment should be based on the clinical diagnosis (community-acquired
pneumonia, health care-associated pneumonia [if infection was acquired in health care setting] or sepsis), local epidemiology &
susceptibility data, and national treatment guidelines"

"When there is ongoing local circulation of seasonal influenza, empiric therapy with a neuraminidase inhibitor [anti-viral influenza drugs] should
be considered for the treatment for patients with influenza or at risk for severe disease."