PROBIOTICS & VIT D: "The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression..These results support the underlying hypothesis that the human gut microbiome and vitamin D metabolism are integrally related"
https://t.co/15rVFa1fkk

"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."
"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."
"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."
"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."
"However, it is the active form of vitamin D, 1,25(OH)2D, that interacts specifically with the vitamin D receptor (VDR) and transacts gene expression."
"Those men with the highest compared to lowest 1,25(OH)2D and activation ratios are more likely to possess butyrate-producing bacteria that are associated with favorable gut microbial health."
"25(OH)D levels vary with site and sun exposure, but 1,25(OH)2D levels do not follow this association."
"the serum 1,25(OH)2D was the factor that explained the highest proportion of the variance in α-diversity (e.g., bacterial species diversity within an individual) at just over 5%"
"Greater α-diversity [gut bacterial species diversity] is associated with higher 1,25(OH)2D levels and larger vitamin D activation and catabolism ratios."
"Overall, apart from known correlates such as race and geographic locations, measures of vitamin D metabolic flux were remarkably associated with microbial β-diversity"
"We report robust correlations between the vitamin D metabolites, 1,25(OH)2D and 24,25(OH)2D, and the gut microbiome in 567 older men representing six geographic sites across the United States"
"Those men with higher levels of 1,25(OH)2D had greater α-diversity, even after adjusting for previously characterized determinants of microbial diversity including age, geographical origin, race, PPI, and antibiotic use."
"Serum 25(OH)D is the preferred clinical measure because it is representative of overall body stores of vit D; however, our results suggest it is the regulation of VDM, reflected by active hormone & metabolic ratios rather than body stores that have the most health implications."
"The positive association between diversity metrics and vitamin D activation and catabolism ratios suggests that physiologically normal vitamin D flux is more likely to occur in individuals with healthy microbiomes."
"In summary, we provide strong evidence of important interactions between host vitamin D signaling and the health of the gut microbiome in older men."

More from Robin Monotti FRSA ⭐

More from Category c19

A brief tutorial in health education to show you how sound health education models have been used for manipulation instead of creating health awareness during the COVID 19 pandemic. We'll uses masks as an example of a health behavior.
Are you ready to explore? 1/n

The Health Belief Model (HBM) consists of 5 components: perceived threat (lethality + Susceptibility),
perceived benefits,
perceived barriers and
cues to action.

Familiarise yourself with the definition of each concept in this table. 2/n
https://t.co/1tOz1cJFvc


Study this diagram to understand how the components are interrelated. 3/n
https://t.co/iUoaqNkgyP


Now let’s apply this to the COVID 19 pandemic.
Review this diagram to see how the HBM applies to the behaviour of mask-wearing.
“perceived susceptibility appeared to be the most significant factor determining compliance” 4/n
https://t.co/xF6uwUx12N


Part I: The HBM
Increase the perceived threat of a disease
1) increase perceived severity: Confusing the general public with CFR & IFR- 2 indicators that are an order of magnitude apart.
People understood wrongly that the fatality rate of C19 is
1/: Avicenna was a Persian scientist, who lived 1000 years ago. He put two lambs in separate cages, which had the same health conditions. But only one lamb could see a wolf that was put in a third cage. The observations were astounding. (h/t @farmer_student) ⬇️a thread⬇️


2/: Both lambs were provided with the same feed. Also, the weight was exactly the same when the experiment started. Several months later, the lamb with sight on the wolf became cranky, restless, weak, and showed a significant weight loss and signs of poor development.

3/: The lamb that was under chronic stress as it was placed in a situation of constant apparent danger died eventually. 🐑🪦 In fact, the wolf did not pose a danger at all, but this was beyond the lamb's perception.

4/: This experiment showed that increased levels of the stress hormone cortisol have a bad impact on the metabolism of mammals. And 1000 years after this experiment, we are facing a similar situation again but with the difference that we are aware of the impact of stress.

5/: Currently, we are overwhelmed with medial and governmental propaganda with respect to a common cold virus (that might hypothetically be more lethal though) that doesn't do harm to the majority of the people. Extreme global measures are taken.

You May Also Like

This is NONSENSE. The people who take photos with their books on instagram are known to be voracious readers who graciously take time to review books and recommend them to their followers. Part of their medium is to take elaborate, beautiful photos of books. Die mad, Guardian.


THEY DO READ THEM, YOU JUDGY, RACOON-PICKED TRASH BIN


If you come for Bookstagram, i will fight you.

In appreciation, here are some of my favourite bookstagrams of my books: (photos by lit_nerd37, mybookacademy, bookswrotemystory, and scorpio_books)