@sbarnettARK Epigenomic biomarkers are becoming more established for #LiquidBiopsy and #CancerScreening, and we have seen the big players positioning themselves in this #epigenomics race recently.

Catching signs of #cancer early is crucially important to the disease management and survival rates, so the question is: how can we find out if there is something wrong going on early enough?

The first generation of high-throughput technologies was predicated on finding mutated (tumor) DNA in the individual's body (somatic), different from their (normal) DNA. Tumor/Normal (T/N) comparisons of the individual's samples, biopsies or ctDNA will indicate if there

are signs of cancer already underway. So why do we need #epigenomic profiling if we can do all this with the detection of mutations? Well, the argument is that if you can see sufficient mutated copies of DNA, cancer may already have progressed beyond the initial stages.

Then people asked the question: is there an earlier mark that we can detect for earlier stages of cancer before the Tumor/Normal mutations signal amps up? Here is where #epigenomics profiling took hold.

(1/14) The World Bank’s 2017 report titled ‘Precarious Drop’ pointed out how nearly 20 million Indian women were ‘missing’ from the workforce during 2004-2012.

(2/14) While media reports and headlines might have put the onus on women themselves, it is hard to ignore that there are many challenges that hinder women from rejoining the workforce post a career-break taken for several reasons, including childbirth.

(3/14) Out of those who manage to rejoin the workforce, many women eventually drop out in less than 6 months. This was due to “lack of awareness about inclusivity” in corporate offices in the ’90s, points out Dr Saundarya, someone who chose to be the solution to this problem.

(4/14) Having experienced all the challenges of a returning female professional, she founded Avtar in 2000, as a diversity and inclusion platform that helps women get a second shot at building their careers.

(5/14) And, recently, in November 2020, she expanded her focus through MyAvtar — a job portal for people from marginalised backgrounds, to include the LGBTQ+ community as well.

half of this website believes that all of your problems can be solved by going to therapy

another half thinks that the entire psychological profession is fake and after some vaguely construed revolution mental health will be solved

what's funny about this is that nothing about it new

I wish this wasn't paywalled because the books Lasch reviewed (in 1976!) sound very familiar. The same kind of dumb debates on this subject that occur constantly here are inherited from boomers

the point Lasch makes towards the end is that all of these books are grasping towards something that neither therapy or politics fully covers, even if both are obviously relevant.

but first, he does a tour through the books. he encounters people who believe all character traits are a product of "propaganda" and "conditioning" that can be fixed with therapy or therapy-like processes, and people who think therapy is a distraction from politics

#RightNow for every singel one of us charities are either directly helping us or helping people or causes we care about 1/11

#RightNow there will be people living on your street who rely on charitable support 2/11

#RightNow you might be heading out to a green space, almost certainly cared for by volunteers and charities 3/11

#RightNow there are charity shops shuttered on your local high street, leaving charities without a key source of income 4/11

#RightNow you'll probably know someone close who has received a vaccination, guided through the process by a volunteer 5/11

So another thread on..... Mars, this time the early years of the space age

#CountdowntoMars #Mars #Perseverance

1964 was a vintage year. The Beatles, Goldfinger, (consults notes – I was very young at the time), my christening and..... oh yes, JPL sent the first missions to the Red Planet @carolynporco

What people forget is that even then so very little was known about the Red Planet as it was not easy to see with then state-of-the art equipment – in that same year of 1964 the official USAF Cartography Center map of Mars still had canals drawn on it as ridiculous as it seems

@Maxwell4Fresno Hi Tyler, I support free bus rides in @CityofFresno . I'm a former college-educated paralegal who was priced out of my native SF Bay Area. I moved to Fresno 3 yrs ago for cheaper cost of living, and a Social Work degree @Fresno_State . -Michaela /1

2/ @Maxwell4Fresno My plans were derailed by illness, hospital, and long application for benefits & housing. I'm too young for 62 yr old affordable apts (58) and too healthy for transitional programs (no drugs or alcohol). I sleep in my car in 2+ yr wait list. N Fresno.-Michaela

3/ @Maxwell4Fresno In my long healing period, I spent thru my savings and became homeless. I used a variety of Fresno's homeless services for women. They were dangerous, unethical, untrained, exhausting, and abusive. I wouldn't recommend them to any woman. Traumatic.-Michaela

4/ @Maxwell4Fresno I had very little money and I had to pay car ins, preserve gas. It takes YEARS in most cases for our homeless, most of whom have a major illness, to be approved for Social Security disability. -Michaela

5/ @Maxwell4Fresno I was required to meet with a @FresnoCountyCA case worker every two weeks about my housing application. I asked for a bus pass or gas voucher, as I couldn't afford to get to these appts. -Michaela

A Black couple put in $400k in home renovations, but their home appraisal barely budged.

When a white friend posed as the homeowner for a new appraisal, the home appraisal went up by $500k!

This is outrageous but unsurprising. Let me explain. /1/

Home ownership is *the* single biggest wealth generator for most families. It builds your retirement nest eggs, allows a family to pass on generational wealth, and you can borrow against a home to pay for big expenses, e.g., children’s college education. /2/

Yet, home ownership is out of reach for many Black people for many reasons. First, discrimination in lending makes it difficult for Black borrowers to obtain a mortgage. Black borrowers are denied mortgages at DOUBLE the rate as white borrowers. /3/

Second, less generational wealth for Black borrowers means they don’t get help from parents and grandparents who can you pay the outrageous down payment that most borrowers need to secure a mortgage. /4/

Finally, Black borrowers on average owe about DOUBLE the amount in student loan debt than white borrowers, and owe more than when they started college(!), which means the dream of home ownership is delayed if not denied. /5/

Israel and Russia held intensive contacts in last few days over humanitarian issues related to Syria. Via ⁦@WallaNews⁩

2-Over last two days, talks between Netayahu and Putin, Israeli DM Gantz and Russian DM, Israeli FM Ashkenazi and Russian FM Sergey Lavrov. Israeli DM team says Gantz spoke to counterpart about "advancing humanitarian issues in the area."

3-Israel and Russia held intensive talks on Syria in last few days

4-Last Wednesday, on day of call between Gantz and Russian DM, Israeli ambassador to Russia Alex Ben Tzvi met w/Russian FM, Putin's Syria envoy Mikhail Bogdanov. IDF attache in Moscow attended. Russian MoD confirmed meeting in statement. Bogdanov and Ben Tzvi met again today

5-Meanwhile, Israeli cabinet convened today at 6:00 PM Israel time. Senior officials called meeting "urgent" to deal w/issue defined as "security-related and classified."

You know what I don’t miss? Parent teacher conferences.

Most of Rocketkid’s teachers were lovely, but we had two that still stick out in my mind as sad/hilarious.

The first one, he was in elementary school. The teacher said it was ‘important’ for us to come in.

1/

So we worried about that for two days until the meeting. What could be wrong? It’s scary for parents to be left hanging like that.

So we meet his teacher, goatee and sunglasses...we live in the boonies and yet there’s something here like he’s trying to be a player.

2/

Not like a lady-player, like he’s got an image of himself in his head. We like teachers, but this guy’s manner is just weirdly kind of pushy a little bit.

Anyway, we sit does in the kid chairs, he’s behind his desk, again, weirdly focused on ‘power,’ somehow.

No idea why,

3/

We ask about our son, he acts as if he forgot that’s why we’re there, says some random stuff, all normal, nothing at all worthy of a conference. I mean, contact and communication is important, but thus just feels off-the cuff entirely.

4/

So then suddenly he gets really intense, but pretends being casual. Like it just occurred to him.

And he says to me, ‘So, I hear you’re a writer.’

What?

I tell him yes, I write comics and some animation and stuff.

He says. ‘I looked you up.’

5/

WAR OF THE BOUNTY HUNTERS, the biggest and baddest Star Wars comics crossover of the modern Marvel era... begins in May.

What is it? Pretty simple:

Boba Fett vs... everyone.

Here’s the launch interview, and some additional thoughts in the

WAR OF THE BOUNTY HUNTERS runs from May to October, kicking off with an issue from me and my longtime friend and collaborator Steve McNiven. (We did Death/Return of Wolverine together, Uncanny Inhumans etc.) He’s INCREDIBLE, and I think this is his best work in ages. I mean...

Steve inked himself (to amazing effect), and the colors there are by the staggeringly talented Laura Martin.

It’s always special whenever I get to work with Steve, and this is no exception. There’s a fight sequence in that issue that (literally) has to be seen to be believed.

The story: Boba Fett has Han Solo at the end of EpV, but we know it takes him a while to get to Jabba in EpVI (he’s not there yet when Lando and Chewie go to Tatooine just after Empire.)

What took so long? Well, someone steals Han, and Boba has to get him back. NO MATTER WHAT.

That journey, which has MANY twists and turns, puts Boba up against the galaxy’s heaviest hitters, since basically all of the big factions and players have an interest in grabbing Han Solo.

I mean, think about it...

A potential problem is looming, and the media are pursuing a new story that builds on the following chain of reasoning: 1) higher inflation is coming;2) if CBs increase interest rates debts will explode and recession may ensue; 3) CBs are caught in an impossible dilemma 1/12

It´s perhaps too complex for some tweets, but.. Registered inflation this year is bound to be higher than present forecasts, resulting from one-off price spikes and base effects That will not start a sustained high inflation process, but temporary higher inflation is possible 2/

For example, Euro Area inflation increased suddenly from several months at -0.3% to +0.9% in Jan. This jump resulted mostly from several base effects, especially the change to German VAT. Inflation expectations increasing but higher in the US than in the EA 3/

The major one-off base effect will come from oil prices that decreased abysmally in March 2020 and have recovered. Some estimates put US inflation in April reaching 4%! After vaccinations, later in the year, pent-up consumer demand will also increase prices.4/

Despite the increased spending of accumulated savings, the savings rate will remain higher than before Covid for precautionary reasons (Fig 1). No permanent spending spree will materialise. Wages will remain subdued for a while (Fig2). Higher but not high inflation is coming.5/

BRITSH ARMY HEADCOUNT REDUCTION (Thread)
Looking back at personnel cuts made in 2010, a reduced Army of 82,000 didn’t help Britain regain its financial strength, it simply signified a hollowing-out of our ability to defend ourselves.
(1 of 25)

It destroyed the credibility of David Cameron’s Coalition Government then and even more so in hindsight. It was military illiteracy on a grand scale. The problem wasn’t so much the reduction itself, but the fact that there was no real strategy behind it, no future plan.
(2 of 25)

Back in 2010, the UK's involvement Iraq and Afghanistan didn’t really serve our national interests (See Ben Barry’s book). If these conflicts were sub-optimal uses of the Army, they raised the important question of what the Army’s underlying raison d’être should be.
(3 of 25)

We hope the Integrated Review will provide a concrete response to this. In the meantime, the Integrated Operating Concept has been much talked about, but we have been left in the dark about what it signifies in terms of strategic priorities and a reconfigured force.
(4 of 25)

The resulting strategy will obviously be threat-driven with Russia, China, North Korea and Iran representing near-peer threats and Islamic terror groups in Africa and the Middle East posing an asymmetric threat. This suggests a mix of high-end and light forces.
(5 of 25)

1/13 #ClimateChange is a result of a mindset, that is based on monoculture, fossil fuels, chemicals, corporate control. @BillGates cannot alter a condition with the same mindset that created it in the first place @Trevornoah @drvandanashiva

2/13 The mad rush for #FakeFood and #FakeMeat, ignorant of the #diversity of our food cultures & the role of biodiversity is a recipe for accelerating the #climatecrisis, the destruction of the planet & our health @drvandanashiva

3/13 The perpetrators of the industrialized & now digitized predatory economic model that has led to worldwide ecological devastation are trying to sell us their solutions as the only path forward @drvandanashiva @NnimmoB

4/13 The #GatesFoundation works to create a friendly regulatory environment to push its innovations regardless of risks or past failures by funding to align to its interests- media, research, start-ups, government programmes & international institutions

5/13 Amnesia and denial of past failures becomes evident with the @gatesfoundation new initiative #AgOne where only digital tech and the #GreenRevolution is seen as the solution to the #ClimateCrisis & #BiodiversityCrisis @drvandanashiva

🧵 @DianeLangberg wrote about NDAs in Christian environments, noting “An NDA is an agreement to hide something. In the cases I have encountered it has always been an agreement to exercise power over and hide sin.... [it is] unlike our Lord.”
1/

NDAs are traditionally “non-disclosure” - don’t talk about specific X. Often in church/ministry cases - they’re overly broad - don’t talk abt *anything* re: your employment

but also may include

“non-disparagement” - don’t say anything negative about us EVEN IF IT IS TRUE
2/

Numerous articles have described the use of NDAs in Christian environments and the conflict with principles described in the very faith supposedly being promoted. I’m linking them here then I’ll offer my 20-year lawyer and victim of silencing (gag order) take on the practice.
3/

“Silence of the sheep” (2018) from @emlybelz described how the conference of catholic bishops has now banned NDAs in abuse cases but how some churches and Christian orgs still use them without

Later in 2018, @scotmcknight discussed NDAs after the Bill Hybels sex abuse scandal, noting that often the stronger party is implicated in sin because the whole reason for the NDA is bc they know that something is wrong and they don’t want it

There hv been concerted efforts by members of the Oyo APC to rewrite history. They repeat so often the lie that Ibadan was a peaceful place bfr Seyi Makinde took over office on May 29, 2019. It has become a case of, repeat a lie often enough, & it begins to sound like the truth.

Immediately after he took over the government in May 2011, a violent clash erupted. The bloody clash described as "a recurring decimal" in the state saw one dead and about 10 injured.

By June 2012, there was another clash. This time between the NURTW and the PDP. The story was that the NURTW were angry that PDP members were singing Arikesola's praises. You can read the report for yourself.

May 2013 - Violence erupted on Thursday in Ibadan, the Oyo State capital, when known members of the ACN and the NURTW made to disrupt a political gathering put together by the leader of Accord Party, Senator Rashidi Ladoja.

August 2013- No fewer than eleven herdsmen have been killed in the last six weeks in some parts of Oke Ogun area; Otu, Ikomu, Igbo-Ora, Iwere-Ile, Iganna, Ilaju and Ado-Awaye.

9 Lessons From 'The Magic Of Thinking BIG' by David J. Schwartz

THREAD 🧵

1. Believing that you WILL succeed is one of the most essential traits of successful people

Think success, not failure.

Remind yourself regularly that you are better than you think you are.

Believe Big.

The size of your success is determined by the size of your belief.

2. Stop Making Excuses

I’m too young/old
I’m not well enough
I’m not smart enough
I’m not lucky enough

Eliminate the habit of making excuses; instead see reasons why you can succeed.

The right attitude and one arm will beat the wrong attitude and two arms every time.

3. Build Confidence & Destroy Fear

Indecision feeds fear.

Action cures fear.

Focus your mind on only positive thoughts and use daily affirmations to help build belief in yourself.

4. Think & Dream Creatively

Big people monopolise listening.

Small people monopolise talking.

There is a reason why the top leaders of our world spend more time requesting advice than they do giving it.

As witch-hunt #3 gets underway by @BeatriceJanzon
@sverigesradio @sr_ekot against me, Keith Begg, a citizen of Ireland and Sweden and no doubt some members of the FB Group I would like to post some questions to the above:
🆘Is it ethical, that the tactics and antics of a state

media station, paid for with taxpayers money, can infiltrate a Private FB group and try to discredit them? This is done in the most authoritarian of states.
🆘Is it ethical that the Honorable David Nabarro from @WHO had to issue a press release due to being deliberately

misquoting in Swedish media?
🆘Are these headlines reflective of what you would see in free media in a democracy, when the rest of the world was posting quite opposite headlines about Sweden?
🆘Does the deliberate distortion of information on Swedish TV constitute any

breaches of trust? Why was it done? After all when the government changed its C19 strategy on the Gov website, they deemed it a mistake?
🆘Not to mind the Italian embassy having to issue three statements over false claims by Tegnell

which were picked up by the media. Do I as a private citizen think that @RSF_en made a big mistake by recognizing Sweden as #4 in terms of Freedom of the Press? ABSOLUTELY. We want to know what they based their decisions on. Because it is clear to many