Ulysses S. Grant would like a WORD
Hogan Gidley: Trump is "the most masculine person to ever hold the White House as the president of the United States" https://t.co/fcoYWyaEhz
— Eliza Relman (@eliza_relman) January 11, 2021
But he didn't go down. He stood there and, while bleeding out, steadily took aim and killed the dude who shot him.
Stone cold.
Grover Cleveland hired a substitute to take his place in the Civil War.
And then he was the guy Polk chose to start a war with Mexico. He did so. And then he conquered Mexico.
One time he was on a hill in Cuba, and he got to watch it get taken by the innovative use of gatling guns supporting regiment of black cavalrymen!
The dude was DETERMINED TO POAST.
He is the third HEAVIEST president, of course, after Grover Cleveland (remember him from above?) and Taft, of stuck-in-the-tub fame.
More from Lyman Stone 石來民
So a few days back I was tweeting about SSRIs. The big question with these drugs is: why do controlled trials routinely show such small effects when practitioners and patients report life-changingly-large effects?
So first off, at this point the evidence is pretty clear that SSRIs and other anti-anxiety/anti-depression drugs truly don't do very much. Their average effects are beneath clinical significance, as I tweeted about here:
Basically, the problem these drugs face is that while they actually see relatively LARGE effects.... but that placebos in those trials ALSO see large effects (and most untreated depression improves within a year anyways).
So basically you have this problem where:
1. The condition tends to improve on its own in a majority of cases
2. Placebo effects for the condition are unusually large
Which means the large crude effects of SSRIs get swamped.
So that raises two new questions.
1. (Not my focus here) Are we treating these conditions appropriately given their untreated prognosis is usually (though certainly not always!!) "goes away in a few months"?
2. Why are placebo effects so unusually large?
So first off, at this point the evidence is pretty clear that SSRIs and other anti-anxiety/anti-depression drugs truly don't do very much. Their average effects are beneath clinical significance, as I tweeted about here:
What's the best recent empirical assessment of SSRI/SNRI effectiveness which deals with heterogeneity and long-term effects in a plausible way?
— Lyman Stone \u77f3\u4f86\u6c11 (@lymanstoneky) December 4, 2020
Basically, the problem these drugs face is that while they actually see relatively LARGE effects.... but that placebos in those trials ALSO see large effects (and most untreated depression improves within a year anyways).
So basically you have this problem where:
1. The condition tends to improve on its own in a majority of cases
2. Placebo effects for the condition are unusually large
Which means the large crude effects of SSRIs get swamped.
So that raises two new questions.
1. (Not my focus here) Are we treating these conditions appropriately given their untreated prognosis is usually (though certainly not always!!) "goes away in a few months"?
2. Why are placebo effects so unusually large?
More from Trump
Today's Twitter threads (a Twitter thread).
Inside: Stop saying "it's not censorship if it's not the government"; Trump's swamp gators find corporate refuge; and more!
Archived at: https://t.co/7JMcAbaULj
#Pluralistic
1/
Monday night, I'll be helping William Gibson launch the paperback edition of his novel AGENCY at a Strand Bookstore videoconference. Come say hi!
https://t.co/k3fvBdqOK0
2/
Stop saying "it's not censorship if it's not the government": I didn't expect the Spanish Inquisition.
https://t.co/7I0MpCTez5
3/
Trump's swamp gators find corporate refuge: The Swamped project.
https://t.co/MUJyIOr2iw
4/
#15yrsago A-Hole bill would make a secret technology into the law of the land https://t.co/57bJaM1Byr
#15yrsago Hollywood’s MP loses the election — hit the road, Sam! https://t.co/12ssYpV46B
#15yrsago How William Gibson discovered science fiction https://t.co/MYR0go37nW
5/
Inside: Stop saying "it's not censorship if it's not the government"; Trump's swamp gators find corporate refuge; and more!
Archived at: https://t.co/7JMcAbaULj
#Pluralistic
1/
Monday night, I'll be helping William Gibson launch the paperback edition of his novel AGENCY at a Strand Bookstore videoconference. Come say hi!
https://t.co/k3fvBdqOK0
2/
Stop saying "it's not censorship if it's not the government": I didn't expect the Spanish Inquisition.
https://t.co/7I0MpCTez5
3/
If you think "It's not censorship unless the government does it," I want to change your mind.
— Cory Doctorow #BLM (@doctorow) January 24, 2021
It's absolutely true that the First Amendment only prohibits government action to suppress speech based on its content, but the First Amendment is not the last word on censorship.
1/ pic.twitter.com/ycbLLDhtrd
Trump's swamp gators find corporate refuge: The Swamped project.
https://t.co/MUJyIOr2iw
4/
Have you seen the stories about how Trump administration officials and staffers for Ted Cruz are finding that no one in the private sector will hire them because they are forever tainted by their former bosses' disgraceful behavior?
— Cory Doctorow #BLM (@doctorow) January 24, 2021
They're bullshit.https://t.co/XvYDPpR9yd
1/ pic.twitter.com/VxisK4d8jV
#15yrsago A-Hole bill would make a secret technology into the law of the land https://t.co/57bJaM1Byr
#15yrsago Hollywood’s MP loses the election — hit the road, Sam! https://t.co/12ssYpV46B
#15yrsago How William Gibson discovered science fiction https://t.co/MYR0go37nW
5/
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs