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The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4

 There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16
Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16
Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16
Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16
Spain has 42 new sequences (orange), including from the island of Mallorca. Many represent new introductions, though some link together & to older sequences (pic 2). Some sequences from Mallorca form tight, distinctive clusters (pic 3).

6/16
The Netherlands has 15 new sequences (orange). All of these are separate introductions, though a few new sequences link together which could be a common exposure source.

7/16
Switzerland has 9 new sequences (yellow). Many are separate introductions. Some sit close to other new sequences & older sequences. In some, geographic distribution implies these are separate introductions (pic 2). Others seem likely to be local transmission (pic 3).

8/16
Australia has 2 new sequences (orange) - they are linked but are a separate introduction, in Victoria.

Norway has 1 new sequence (orange). Though hard to see in the picture, it is a separate introduction & not connected to older sequences.

9/16
Germany has 2 new sequences (orange). Both representing separate introductions (pic 1).

The USA has 1 new sequence, from New Mexico (orange). It is 1 mutation away from older sequences - this could be local transmission or exposure to a common source (pic 2 & 3).

10/16
There are 3 new non-South African sequences in 501Y.V2 from Germany & Australia -- & Norway for the first time.

11/16
There is 1 new sequence each from Australia & Germany. The new Australian seq (yellow, bottom) is a separate introduction. The German seq (orange) is related to older German sequences but doesn't branch directly & is 5 mutations away, so may be exposure to a common source.

12/16
There is 1 new sequence from Norway in 501Y.V2 for the first time.
It is similar to sequences from England and France, which may onward transmission in Europe or a common source outside of Europe.

13/16
Finally, in the S:E484 build, there are 3 new sequences that fall in 20B/S.484K from Denmark, which indicate at least 2 introductions.

14/16

https://t.co/HpPeemTCkW
As usual, the country-plot is also updated. As always - interpret with care! Many countries are preferentially sequencing S-drop-out & S:N501 samples, & so the frequencies represented are often not reflective of real life.

15/16
https://t.co/c7wlQOLRiq
As always, you can read more about all the variants I'm tracking at https://t.co/wVE7ubYBoy!

16/16

More from Dr Emma Hodcroft

Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz


There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20


Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20


Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20


Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw


There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12


In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12


The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12


Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12
FOR LATER READ
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Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0


There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14


First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14


France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14


Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL


In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18


Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18


Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18


France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL


Denmark has 43 new sequences (in orange). These indicate additional introductions, as well as further expansion of the existing large local transmission cluster we saw previously (shown in zoomed divergence view).

2/12


10 new sequences from Portugal (orange) indicate additional, separate introductions.

3/12


Singapore has 5 new sequences (yellow). These indicate at least 5 separate introductions for the total of 6 sequences, with two identical sequences likely being 1 introduction.

4/12


5 new sequences from the US, from Florida & California (older sequences crossed through).

Zooming in (divergence view) on the California cluster, the relationship between these samples is difficult to infer from phylogenies alone.

5/12
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Dr. Simon \u30c4
Dr. Simon ツ
@goddeketal
1/ One year of destroyed economies, social isolation & deep social splits calls for an anniversary ⬇️thread ⬇️ to celebrate the RT-qPCR manuscript by Christian Drosten (@c_drosten) & Victor Corman (@vmcorman), submitted on 21st Jan 2020 to @Eurosurveillanc. #UnbiasedScience


2/ Before this very publication, virologists were neither treated like superstars, nor were they considered icons or half-gods. In 2009, Drosten almost succeeded in installing the false premise virology could supersede holistic medical sciences as discussed in this thread.

3/ Drosten is a virologist. He neither has any background in epidemiology, nor has he ever worked in the civil service. He also doesn’t have a background in public health. Yet he and his colleagues affect our daily lives to the level of whom to meet up or how to flush the toilet.


4/ Before January 2020, Drosten and Corman were common virologists at Charité Berlin, whenever they were not involved in economic implications (https://t.co/UTDwG8U7Du). Other than that, they looked at coronaviruses in dromedary calves in the Middle East or Africa. 😍 #cute


5/ Finally in Jan 2020, the published paper laid the theoretical grounds for the current pandemic, the RT-qPCR mass testing-religion, for which he was awarded his second German Federal Cross of Merit (he received the first one in 2005 for developing the SARS-CoV PCR test).
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Kirsti Miller
Kirsti Miller
@KirstiMiller30
@LaurenMurphyMMA @_Miatonin @AOC There is no no differences in strength between men and women are seen when normalized for muscle cross-sectional

@_Miatonin @AOC It is reductionist (and wrong) to suggest the performance gap is all about biology (e.g. testosterone).

@_Miatonin @AOC Based on the present evidence, it is reasonable to suggest that biological, psychological, and sociocultural factors contribute to the range of gender gaps observed across sports.

@_Miatonin @AOC Men and women exhibit similar relative responses to resistance training, with no gender-specific responses noted after 10-weeks of resistance

@_Miatonin @AOC A number of other gender-‘independent’ factors contribute to the regulation of adult muscle mass, including genetics, race, adiposity, training, diet, and birth
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What The Trans!?
What The Trans!?
@WhatTheTrans
A thread on how absurd the UK is on transgender issues and how the UK got so transphobic

In 2015 Parliament held an inquiry looking into the state of Transgender equality. Trans people of all stripes outlined many different problems across many, many different areas.

As a result Parliament created a list of recommendations including legal recognition for non binary people, gender recognition act reform, allowing 16 year olds to change their legal gender and reform of NHS gender identity services.

The government under Theresa May ignored everything that was recommended except for Gender recognition act reform. This act came into law in 2003 and gave trans men and women (but not non-binary people) the ability to legally change their gender on their birth certificates.

The process at that time to change your birth certificate under the GRA was to make an application to a panel of cisgender people who would decide if you were sufficiently trans based on your payslips, photo ID and bank statements. You would not get the option to speak to them.

(Also this process cost £140 which is just a tax on being trans)
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Myles McNulty
Myles McNulty
@MylesMcNulty
@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10
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Scott Coley
Scott Coley
@scott_m_coley
The reason that so many conservative evangelicals these days appear to be moral relativists is that they *are* moral relativists.

They would deny this, of course. But that doesn’t make it any less true. Here's why.

They’ve bought into the premise that all statements are either fact or opinion: facts are objective and verifiable; and everything else is opinion—subjective and unverifiable. In other words, they've bought into full-fledged modernism.

From there, the secular path to moral relativism places all moral statements in the “opinion” category. On this view, morality is subjective—dependent on cultural context, historical background and the like.

Conservative evangelicals recoil from this approach, as they should.

So instead, they place morality in the “fact” category, claiming that moral truth is objective and empirically verifiable.

And how is moral truth empirically verified? The Bible, of course. Problem solved.

This is tempting, for two reasons. First, Scripture is entirely true; and much of that truth pertains to morality.

Second, apart from special revelation, it’s difficult to imagine where we might go to find empirical verification of moral truth—you can't *see* moral properties.
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Now when Indian Muslims are thrown to wolves it’s Pakistani & Bangladeshi Muslims with whom they kept distance are the only ones feeling their pain. None of the people who they invited for Eid Milan. Qawali & Mushaira are there for them. Such people invoke wrath upon themselves

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Some thoughts on episode 54 of #Hercai

If you ever cross the distance and come to me, come with love that blooms in your heart.
~ Şems-i Tebrizi

#Reyyan #Miran #ReyMir #EbruŞahin #AkınAkınözü
#HercaiThoughts


1
I have to make a note before writing about this episode. I was the person (still am) who thinks that bringing back D. was a bad idea. I repeat it that for me the writing of S1 and S2 is like tossed into the bin with that plot evolution, but they had to invent something+
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2
+ to be able to continue to prolong the general story after Aslan’s story did not work out. All the suffering of M., all the crying seems for “nothing” for two seasons and we viewers are also kind of fed up in seeing him cry all the time when with the upcoming episodes+
#Hercai

3
+he is justified the most to cry. With her resurrection now the attention shifts back to Miran’s storyline and I don’t know if I like this to be honest. This said, Dilsha is here and we have to deal with her.
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So, my comments are going to be how I find they wrote her into the story, the details we get to know, the flashbacks we get to see, the way it was filmed and directed, with leaving out if I agree on it or not but describing along the way what I saw.
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Margatha Natarajar murthi - Uthirakosamangai temple near Ramanathapuram,TN
#ArudraDarisanam
Unique Natarajar made of emerlad is abt 6 feet tall.
It is always covered with sandal paste.Only on Thriuvadhirai Star in month Margazhi-Nataraja can be worshipped without sandal paste.


After removing the sandal paste,day long rituals & various abhishekam will be https://t.co/e1Ye8DrNWb day Maragatha Nataraja sannandhi will be closed after anointing the murthi with fresh sandal paste.Maragatha Natarajar is covered with sandal paste throughout the year


as Emerald has scientific property of its molecules getting disturbed when exposed to light/water/sound.This is an ancient Shiva temple considered to be 3000 years old -believed to be where Bhagwan Shiva gave Veda gyaana to Parvati Devi.This temple has some stunning sculptures.
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Yantrodharaka Anjaneya Temple, Hampi, Karnataka.

This temple dedicated to pawanputra Hanuman, near the banks of Tungabhadra river was built by dwaita philosopher and rajguru of the Vijayanagar empire, Sri Vyasaraja around +500 years ago.


:It is only in this temple that Hanuman appears in a prayer position. In this image, Bhagwan Hanuman’s crown has been formed by his tail.12 monkeys have been carved around this amulet.


:They represent the 12 days Sri Vyasaraja prayed to Hanuman ji. Each monkey holds the tail of the monkey in front of him but is facing backward. Seed syllables have also been carved around the amulet.


:It is believed that Sri Vyasaraja used to draw a picture of lord Hanuman here on the rocks before offering prayers using charcoal and the sketch disappeared after prayers.This incidence happened for 12 days in a row until he pleaded to bhagwan to appear in front of him.


On the 12th day, Hanuman ji appeared in front of Sri Vyasaraja and blessed him. Hanuman asked Sri Vyasaraja to constrain him in a hexagonal amulet & install him in that place.
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