BC SCIENCE
Saved by @Alex1Powell

Omega-3 Research (thread):

 I've been discussing omega-3 fats on here more recently, so I wanted to put together a short collection of larger meta-studies on some of their various health benefits

I tried to pick a variety of studies, with as much data in each one as possible, I may add more over time
Omega-3 fats seem to have the most benefits when it comes to reducing chronic inflammation, many mental illnesses like depression, ADHD, and schizophrenia, promoting gut/microbiome health, and preventing neurodegenerative diseases like Alzheimers and dementia
Interestingly, evidence for improvement with cardiovascular disease is more variable than many other issues, though there are many promising studies

The majority of studies with omega-3 fats and cancer seem to generally show benefit, but this also varies in a few studies
Keep in mind that the majority of these studies are done with fish oils rather than whole seafood

Personally I believe that with this taken into account we will likely see much more benefit to health issues using whole seafood as it's PUFA are less likely to be oxidized
Omega-3 fatty acids and the treatment of depression: a review of scientific evidence
https://t.co/O5vnMDhKlt
Effects of Omega-3 Fatty Acids on Immune Cells
https://t.co/8OTtbyj43M
Polyunsaturated Fatty Acids: What is Their Role in Treatment of Psychiatric Disorders?
https://t.co/88vBXRrpdO
Cardiovascular, electrophysiologic, and hematologic effects of omega-3 fatty acids beyond reducing hypertriglyceridemia: as it pertains to the recently published REDUCE-IT trial
https://t.co/QvvrQ3zXuo
Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials
https://t.co/v3JkTU5NgM\
Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease
https://t.co/lvXTQjTrhM
Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms
https://t.co/ijdAfEhOXF
The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis
https://t.co/neeGuXZr6l
Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications
https://t.co/rV8uU0dlWu
Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011–2014
https://t.co/dYkts7Ieq4
Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function
https://t.co/bIxXStNDMZ
Dietary Supplementation with Anti-Inflammatory Omega-3 Fatty Acids for Cardiovascular Protection: Help or Hoax?
https://t.co/0qhUC7uRwb
Omega-3 Fatty Acid and Nutrient Deficits in Adverse Neurodevelopment and Childhood Behaviors
https://t.co/bacwhTDSGq
Role of dietary fatty acids in microglial polarization in Alzheimer’s disease
https://t.co/JhxpPa1Hz1
Impact of Omega-3 Fatty Acids on the Gut Microbiota
https://t.co/RZbxhVOl6q

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Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval


⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.
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@strain_rate
1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.


The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.


2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.


3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.


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Michael Lin, PhD-MD
Michael Lin, PhD-MD
@michaelzlin
Fellow academics, when are we going to start fixing our urgent structural problems that strain family bonds and present ongoing barriers to diversifying our educational and scientific leadership? You wonder, what the heck is this guy talking about?
1/n

We’re all very familiar what I am talking about, actually: the impossibility for most academics in the life sciences to do their jobs in a reaonable amount of time, due to more and more demands on writing grants, and to a lesser degree, papers.
2/n

As of yesterday I hadn’t intended to write about this subject, but was wondering as I finished a Saturday of straight work, what happened to all my time? Why has WFH not reduced my pile of tasks to do? Instead why is my to-do list growing bigger and bigger?
3/n

I decided to figure out how much time our jobs actually require. I estimated per year (m=month, w=week, d=day, h=hour):
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Meetings of all sorts: 10h/w x 48w= 480h
Replying to email: 2h/d x 365d = 730h
Attending and giving talks: 2h/w x 50w = 100h
4/n

Papers: If each person needs 2 papers during a 5y stint, and you run a 7.5-person lab, then you need 7.5 papers per 2.5y = 3 papers/y. Throw in a review and it’s 4 papers. If you need 15d at 8h/d per paper, that’s 480h writing papers.
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Wonder of Science
Wonder of Science
@wonderofscience
These 'Beach Animals' were created by Theo Jansen as a fusion of art and engineering. The kinetic structures walk on their own and get all their energy from the


Watch the full video on Youtube:
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Bert Hubert
Bert Hubert
@PowerDNS_Bert
Recently I learned something about DNA that blew my mind, and in this thread, I'll attempt to blow your mind as well. Behold: Chargaff's 2nd Parity Rule for DNA N-Grams.
If you are into cryptography or reverse engineering, you should love this.
Thread:


DNA consists of four different 'bases', A, C, G and T. These bases have specific meaning within our biology. Specifically, within the 'coding part' of a gene, a triplet of bases encodes for an amino acid


Most DNA is stored redundantly, in two connected strands. Wherever there is an A on one strand, you'll find a T on the other one. And similarly for C and G:

T G T C A G T
A C A G T C A

(note how the other strand is upside down - this matters!)


If you take all the DNA of an organism (both strands), you will find equal numbers of A's and T's, as well as equal numbers of C's and G's. This is true by definition.
This is called Chargaff's 1st parity rule.
https://t.co/jD4cMt0PJ0


Strangely enough, this rule also holds per strand! So even if you take away the redundancy, there are 99% equal numbers of A/T and C/G * on each strand *. And we don't really know why.
This is called Chargaff's 2nd parity rule.
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You can write this in any language of your choice. It is the connecting chords with the divine and your inner self.

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SRI CHAMPAKADHAMA SWAMY, BANNERGHATTA HILL, BENGALURU (KAR)
#bharatmandir

The shrine is dedicated to Sri Vishnu along with Devi Lakshmi and Bhoodevi.
It is built in an area full of Champaka trees.
As champaka flowers are offered to Sri Vishnu here, it is called Champakadhama.


It is believed that King Janmejaya had sarpa-dosha. To get rid of it, he took bath in the nearby pond. He emerged with a golden body and sarpa-dosha was also removed. The pond is called Swarnamukhi and believed to have curative powers.
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It is also believed that this forest area was the Dandakaranya where Sri Ram stayed in exile.
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Some thoughts on episode 53 of #Hercai

Love,that is not real,has no passion. Its fire turns into embers, it doesn’t not smell. The day, the night, the moon&year burn without sun, light, comfort&sleep.
Ömer Hayyam

#Reyyan #Miran #ReyMir #EbruŞahin #AkınAkınözü
#HercaiThoughts


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PRAISE
The praise in this episode goes foremost to Ebru because she portrayed Reyyan so realistically like a woman who truly lost her unborn child. I was in awe and pain watching her along the episode, all her breakdowns and tears were so real.
#Hercai

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Of course also Akın took his part and did his part masterfully, but he rightfully was the one who stood aside in this specific episode that needed to be about Reyyan’s pain and thus concentrated on Ebru.
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I don’t know who wrote ep. 52 but ep. 53 was going strong once more on symbols: roses, stones, fire and trees were incorporated and especially the ReyMir dialogues were written very well. I truly loved every ReyMir scene.
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Tej Dosa 😂🧠...
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(A THREAD)

18 Things I Would Do At 18:

I was a dumb 18-year-old. I thought I had the world figured out. I didn't.

I stayed up till the wee hours. Drank every liquor invented.

Partied non-stop. Woke up after noon.

Surfed the web aimlessly.

Read BS self-help.

Repeat.

If I could do it all over again, here's 18 things I would do...

PHASE ONE: GET MY MIND RIGHT

ACTION #1: Break the chains - I wish I made the decision earlier. I didn't. I was scared. Anxious. Nervous. I knew once I made the decision, there was no going back.

Don't be like me.

Make the decision at 18. The decision to pave your own path in life. To go against the herd. To choose your own adventure. To commit to whatever sets your heart on fire.

ACTION #2: Cut off every negative person in your life.

Scroll through the contacts in your phone...

Notice how the names make you feel.

Delete any and all names that fill you with doubt and negativity.

ACTION #3: Condition your mind to embrace the producer mindset instead of the consumer mindset.

Consume 20% of the time. Produce 80% of the time.

Case closed.

ACTION #4: Set an intention to make $10k a month and write it out every MORNING and NIGHT as if you already achieved it (in the past tense).

Visualize yourself already having the money as you write.

Cheesy?

Yes.

Does it work?

Yes.

PHASE TWO: EDUCATION
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