
2020 has been extraordinary.
But we wanted to share the 10 reasons we are proud of 2020 by the S-Lab research group of @PICU_BCH & @BacrUob @unibirmingham
AND to say a HUGE 'thank you' to everyone who has made this possible #teamscience #PedsICU #2020


Hussin Albargi @AlBaRqi14 (PhD student: paediatric prehospital cardiac arrest)
Mirjam Kool @mirjam_kool (ACF – post-arrest #TTM Intra-arrest physiological monitoring @ILCOR) & 1st publication! https://t.co/9PIOYh8hub

d. Trystan Gruffydd @TrystanGruffydd (BMedSci student – GCS prognostication post-TBI @ISPNeurosurgery ). & many more stars of the future

Helped co-ordinate UK @PICSociety involvement in #NIHR & UK #COVID19 / #PIMSTS research. Local PIs to @GenomiccStudy @RecoveryICU
https://t.co/XfdUtytsqI

Chaired #PIMSTS @BWC_NHS MDT research group – awesome commitment and dedication from the whole paediatric acute care research team!
Collaborated in #COVID19 guidance for @ESPNIC and shared with colleagues in India, USA and wider world via multiple @PICSociety webinars and @JohnsHopkins https://t.co/sbS88ut9TD
https://t.co/SraMJi0BP6
https://t.co/OYJ7ydX35N
https://t.co/6HxD9zI8rQ
https://t.co/CM5slPOQQC
https://t.co/UJkjKtu269
@RowberryTracey Leads the @ESPNIC_Society #Whatseizure? EU wide exploring of #qEEG #aEEG practice - still time left to reply!
Shared implementation of bedside #qEEG monitoring @PICU_BCH https://t.co/KEfgJU8yeb

@WillMcDevitt1 & @bch_neurophys questioned the role of SSEPs in #postarrestcareinkids https://t.co/a6XsX6AaiU

#NEUROPACK nearly complete! Prognostic uncertainty in #PostArrestCareinKids https://t.co/9ss0Rs5mbh
#PREPACK study with @WarwickCTU exploring the impact of bystander CPR
#NAP7 @NAPs_RCoA CA during critical care transport, with @jas_soar

Delivered @NIHRresearch funded @PermitStudy multicentre 14 site prospective study, feasibility assessment, PERMIT intervention development and now ready for Phase 3 in 2021 & publications++


Travelled the virtual #pedsicu world to share S-Labs work @EAPSCongress @ERC_resus @Ilcor_org @PICSociety @icurehab @WFPICCS #pedsicu #icurehab conferences
Exploded twitter with #BCHNEURO20 x2 talks DM to @drzaf_pic!]

https://t.co/1SkxkuiXuT

A brilliant #pedsicu book, and an invalulable (free!) app https://t.co/sN1fYkCseq
https://t.co/p0SOAGy4qW

#COVID19 #vaccinate #NeverForgotten
https://t.co/ULlramDlF6
and share with you the S-Lab group publication list
https://t.co/IMWQJDY1Gu

Collaborations always welcome! @BarneyUoB
Keep safe all & #BeKind
Credits:@charliemackesy

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Why can cefepime cause neurological toxicity?
And why is renal failure the main risk factor for this complication?
The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.
#MedTwitter #Tweetorial
2/
Let's establish a few facts about cefepime:
🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)
https://t.co/rjYG1BfGPR
3/
The first report of cefepime neurotoxicity was in 1999.
A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.
✅All symptoms resolved after hemodialysis.
https://t.co/u7JLVitQpp
4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).
💡The main risk factors = renal failure and lack of dose adjustment for renal function.
https://t.co/nxbnzSq8AR
5/
What about cefepime induces neurotoxicity?
One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.
This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).
https://t.co/Lf4BhON9IY
Why can cefepime cause neurological toxicity?
And why is renal failure the main risk factor for this complication?
The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.
#MedTwitter #Tweetorial

2/
Let's establish a few facts about cefepime:
🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)
https://t.co/rjYG1BfGPR

3/
The first report of cefepime neurotoxicity was in 1999.
A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.
✅All symptoms resolved after hemodialysis.
https://t.co/u7JLVitQpp

4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).
💡The main risk factors = renal failure and lack of dose adjustment for renal function.
https://t.co/nxbnzSq8AR

5/
What about cefepime induces neurotoxicity?
One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.
This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).
https://t.co/Lf4BhON9IY

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Some random interesting tidbits:
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2) Facebook engineered ways to access user's call history w/o alerting users:
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3) The above also confirms @kashhill and other's suspicion that call history was used to improve PYMK (People You May Know) suggestions and newsfeed rankings.
4) Docs also shed more light into @dseetharaman's story on @Facebook monitoring users' @Onavo VPN activity to determine what competitors to mimic or acquire in 2013.
https://t.co/PwiRIL3v9x
