2020 has been extraordinary.

But we wanted to share the 10 reasons we are proud of 2020 by the S-Lab research group of @PICU_BCH & @BacrUob @unibirmingham

AND to say a HUGE 'thank you' to everyone who has made this possible #teamscience #PedsICU #2020

1)In the last 12 months we have built up a team of Neuro-critical care, resuscitation science, early rehabilitation and COVID19/PIMS-TS researchers for in Birmingham to improve the lives of critically unwell children. Currently called the S(cholefield)-Lab pending a better name!
2)In 2020 we watched our early career researchers shine

Hussin Albargi @AlBaRqi14 (PhD student: paediatric prehospital cardiac arrest)
Mirjam Kool @mirjam_kool (ACF – post-arrest #TTM Intra-arrest physiological monitoring @ILCOR) & 1st publication! https://t.co/9PIOYh8hub
c. Rosie Watts (Med student - BACC-PACK audit of #TTM @PICU_BCH and our need to improve quality of #TTM).
d. Trystan Gruffydd @TrystanGruffydd (BMedSci student – GCS prognostication post-TBI @ISPNeurosurgery ). & many more stars of the future
3) We fought💪with the world against #COVID19

Helped co-ordinate UK @PICSociety involvement in #NIHR & UK #COVID19 / #PIMSTS research. Local PIs to @GenomiccStudy @RecoveryICU

https://t.co/XfdUtytsqI
Ground breaking #SARSCOV2 antibody research with @unibirmingham @AlexRichter3 Graham Taylor @ImmunologyUoB et al https://t.co/mrHD4hHwCu

Chaired #PIMSTS @BWC_NHS MDT research group – awesome commitment and dedication from the whole paediatric acute care research team!
Discovered cardiac presentations in #PIMSTS https://t.co/gjmneevgsb

Collaborated in #COVID19 guidance for @ESPNIC and shared with colleagues in India, USA and wider world via multiple @PICSociety webinars and @JohnsHopkins https://t.co/sbS88ut9TD

https://t.co/SraMJi0BP6
Pushed for UK wide @PICSociety #pedsicu research in to #pimsts epidemiology and treatment with @PicPod_Podcast @pic_pram et al
https://t.co/OYJ7ydX35N

https://t.co/6HxD9zI8rQ
@Dr_Hari_Krishna Leads the UK @PICSociety #PICSSG paediatric consortium for #GCSNeuroCOVID with the brilliant @ericka_fink
https://t.co/CM5slPOQQC
and of course are still trying to help get urgent funds for for more #covid19 #pimsts research for children. Thank you!! @actionmedres #PedsICU

https://t.co/UJkjKtu269
4) Shared, improved & explored #pedsicu neuro-monitoring #neuropicu
@RowberryTracey Leads the @ESPNIC_Society #Whatseizure? EU wide exploring of #qEEG #aEEG practice - still time left to reply!
Shared implementation of bedside #qEEG monitoring @PICU_BCH https://t.co/KEfgJU8yeb
Created new and exciting international #qEEG links with @ESPNIC_Society #neurosection @AlexisTopjian @DrSaptharishi et al!

@WillMcDevitt1 & @bch_neurophys questioned the role of SSEPs in #postarrestcareinkids https://t.co/a6XsX6AaiU
@Dr_Hari_Krishna continues to push the complex boundaries of multi-modal monitoring and big data analysis in paediatric #TBI and other brain injury
5) Resuscitation science takes off
#NEUROPACK nearly complete! Prognostic uncertainty in #PostArrestCareinKids https://t.co/9ss0Rs5mbh
#PREPACK study with @WarwickCTU exploring the impact of bystander CPR
#NAP7 @NAPs_RCoA CA during critical care transport, with @jas_soar
& S-Lab have supported the big year of @Ilcor_org COSTR resuscitation evidence reviews, @ResusCouncilUK and @ERC_resus guideline development. Essential to keep the focus on children's resuscitation science! https://t.co/9W74FsusH8
6) Its been the year of PERMIT(ing) Early Rehabilitation and Mobilisation in UK #pedsicu
Delivered @NIHRresearch funded @PermitStudy multicentre 14 site prospective study, feasibility assessment, PERMIT intervention development and now ready for Phase 3 in 2021 & publications++
& none of which would have happened without a huge team working with us from B'ham, around the UK (and world!) - especially our brilliant @PICU_BCHres team (a pre-covid photo memory!)
7) We embraced @zoom_us (and many friends virtually!)
Travelled the virtual #pedsicu world to share S-Labs work @EAPSCongress @ERC_resus @Ilcor_org @PICSociety @icurehab @WFPICCS #pedsicu #icurehab conferences

Exploded twitter with #BCHNEURO20 x2 talks DM to @drzaf_pic!]
& Provided a virtual support network (hug) for @PICU_BCH during #COVID19 on the #9:09 daily support meeting

https://t.co/1SkxkuiXuT
8) We saw some true 'labour of loves' come to fruition for @Dr_Hari_Krishna and his hard workers : @finegoulden @aakashdeeparora @PicPod_Podcast

A brilliant #pedsicu book, and an invalulable (free!) app https://t.co/sN1fYkCseq
https://t.co/p0SOAGy4qW
9) We sadly remembered our fallen friends and inspirational colleagues
#COVID19 #vaccinate #NeverForgotten

https://t.co/ULlramDlF6
10) Finally, if papers are the currency of #academictwitter then we finish by proudly paying our part, thanking for the hours put in by #editors #peerreviewers #colleagues #friends! eg @RobertCTasker 🌟
and share with you the S-Lab group publication list
https://t.co/IMWQJDY1Gu
2020 was an extraordinary year. For many 1 to forget. But we hope you don't mind us sharing why S-Lab group will take 2020 as a start onwards to something even better in 2021.

Collaborations always welcome! @BarneyUoB

Keep safe all & #BeKind

Credits:@charliemackesy
@threadreaderapp unroll

More from Health

1/15
Why can cefepime cause neurological toxicity?

And why is renal failure the main risk factor for this complication?

The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.

#MedTwitter #Tweetorial


2/
Let's establish a few facts about cefepime:

🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)

https://t.co/rjYG1BfGPR


3/
The first report of cefepime neurotoxicity was in 1999.

A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.

✅All symptoms resolved after hemodialysis.

https://t.co/u7JLVitQpp


4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).

💡The main risk factors = renal failure and lack of dose adjustment for renal function.

https://t.co/nxbnzSq8AR


5/
What about cefepime induces neurotoxicity?

One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.

This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).

https://t.co/Lf4BhON9IY

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