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Saved by @Alex1Powell

2020 marks the start of the quantum dot revolution.

 Completely ignoring the fact that "photocatalytic generation of reactive oxygen species (ROS) from quantum dots (QDs) has been widely reported."
Results: It was found that whereas singlet oxygen (1O2) was not produced by photoexcited QDs, superoxide anion(O2− )and hydroxyl radicals(OH) were generated by QDs, especially in the presence of a physiological concentration of electron donating agent including NADH.
Using cell metabolic activity assays and various probes of ROS generation, the formation of ROS in cellular environments was demonstrated.
Conclusion: Illumination of QD-treated cells and bacteria with light did affect viability. The above results, together with those of assays in the presence of various scavengers of specific ROS, indicate that the formation of ROS by QDs mainly proceeded via electron transfer.
Some electrons are directly transferred to O2 to generate reactive oxygen species (ROS) in the ETC.
... As signaling molecules, ROS play an important role in cell proliferation, hypoxia adaptation and cell fate determination, but excessive ROS can cause irreversible cell damage and even cell death.
Electron transfer is a process by which an electron moves from one atom or molecule to another. It is a key concept in redox chemistry – the chemistry of reactions where one reaction partner loses electrons (oxidation) while the other gains electrons (reduction).
Ferric means the iron atom has lost three electrons to form Fe+3, and ferrous means the iron atom has lost two electrons to form Fe+2. ... For example, ferric would be Fe(III) indicating Fe+3, and ferrous would be Fe(II) indicating Fe+2.
Iron(III) oxide-hydroxide or ferric oxyhydroxide is the chemical compound of iron, oxygen, and hydrogen with formula FeO. The compound is often encountered as one of its hydrates, FeO·nH ₂O [Rust].
Similar behavior is exhibited by some iron compounds, such as the ferrites and the mineral magnetite, a crystalline form of the mixed iron(II,III) oxide Fe3O4 (although the atomic-scale mechanism, ferrimagnetism, is somewhat different).
https://t.co/TPBtYuGPVR
So basically superparamagnetic piezoelectric crystalline nanoparticles dressed up as viruses do indeed cause oxidative stress related diseases.
Activated by light?

More from NotTheMacAnon

NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
This nonspecific cation channel opens when illuminated with blue light, depolarizing the cell [4, 6] to trigger action potentials cells with high temporal precision [5]. Since the initial discovery of ChR2, many modifications have been made to refine the kinetic properties.

For example, ChETA, engineered to address limitations of spike fidelity with ChR2, has faster temporal kinetics and can maintain reliable spike precision up to 200 Hz [7].

Halorhodopsins (NpHR), light-gated chloride pumps activated by yellow light, allow for temporally specific hyperpolarization with single spike precision [8–10].

Archaerhodopsin-3 (Arch), a yellow light-activated outward proton pump, is an increasingly popular tool for light-induced hyperpolarization to inhibit cellular activity. Arch recovers spontaneously from inactivation with a much shorter recovery time than NpHRs [11].

Arch currents continue to increase with increasing light intensity, while NpHRs saturate [11]. The increased light sensitivity of the ArchT variant, along with better membrane targeting, allows for improved neural silencing both at cell bodies and terminals [12].
LIFE
NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
If you shine light of high enough energy on to a metal, electrons will be emitted from the metal.
SCIENCE
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NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
👍🏻


https://t.co/0ywQ1y5NDj

Pott found an association between exposure to soot and a high incidence of scrotal skin cancer in chimney sweeps. This cancer is now known as Pott's or chimney sweep cancer.

Coal contains trace amounts of naturally-occurring radioactive elements. The process of burning coal at coal-fired power plants, called combustion, creates wastes that contain small amounts of naturally-occurring radioactive material (NORM).

Fly ash particles (a major component of coal ash) can become lodged in the deepest part of your lungs, where they trigger asthma, inflammation and immunological reactions.
SONG
NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector.

Viral vectors are tools commonly used by molecular biologists to deliver genetic material into cells.

Viruses have evolved?

specialized molecular mechanisms

to efficiently

transport their genomes

inside the cells they infect.

Delivery of genes, or other genetic material, by a vector is termed transduction and the infected cells are described as transduced.

A transducer is a device that converts energy from one form to another. Usually a transducer converts a signal in one form of energy to a signal in another.
HEALTH
NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
During a normal pregnancy, oxidative stress enhances antioxidant mechanisms that are capable of reacting by way of enzyme activity and non-enzyme free radical deactivators. However, pregnancy is also a state in which this adaptation and balance may be easily disrupted.

There is strong evidence that a chronicin flammatory reaction combined with the presence of a local oxidizing environment may play a vital role in the etiology and development of complications during pregnancy.

In late pregnancy, damage to DNA (especially when it is caused by oxidative stress) is associated with pre-eclampsia(PE), intrauterine growth restriction (IUGR), and the death of mothers in developing countries; it largely determines pregnancy – related susceptibility to diseases

The referential values of ROS and NOS and their minimal and safe concentrations or physiologically beneficial concentrations are yet to be determined.

The measurement of oxidative stress in vivo is perceived as controversial,

as the sen-sitivity and specificity of various oxidative stress markers is unknown.. .
HEALTH

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Jail all false accusers
Jail all false accuser...
@Hammertonhal
The very first section of Robson's allegations is an example of how when he realizes a certain true part of his story does not support his goals he simple changes it to a lie.

He and Joy repeatedly stated under oath that Target run the 1987 dance contest.

Wade 2005 testimony


Joy 2016 deposition


Wade 2013 Apr declaration

blacked out but it's clearly Target not MJJ Production


Wade 2013 Apr Complaint


Wade June 2013 first amended complaint
FOR LATER READ
Evil Saint
Evil Saint
@sanctemalum
8 rules the top play by that those at the bottom should adopt.

— Thread
(requested by followers)

1. Leverage

Most poor people don't leverage. Trying to get everything done yourself will limit you to only how much you can do.

Get more hands working for you, and find a way to pay or show them what's in it for them.

2. Trust

When doing business, poor people would require collateral from strangers, but excuse those close to them because they *trust* them.

That's how you get scammed.

The unspoken rule is to know your safety net whenever you're not taking collateral.

Never need to trust.

3. Morality

Never seen a very successful businessman say "This is not a good thing, it's evil."

It's either good for business or bad for business. Its either effective or ineffective.

Morality will only limit you.

4. Reciprocity

Expecting someone to help you because you helped them in the past is ludicrous.

If you're no longer useful to them, people have no reason to help you.

"Whenever you see water flowing upstream it means someone it repaying a kindness."

— 48 Laws Of Power
LIFE , FOR LATER READ , SELF DEVELOPMENT
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Cory Doctorow #BLM
Cory Doctorow #BLM
@doctorow
Today's Twitter threads (a Twitter thread).

Inside: Planet Money on HP's myriad ripoffs; Strength in numbers; and more!

Archived at: https://t.co/esjoT3u5Gr

#Pluralistic

1/


On Feb 22, I'm delivering a keynote address for the NISO Plus conference, "The day of the comet: what trustbusting means for digital manipulation."

https://t.co/Z84xicXhGg

2/


Planet Money on HP's myriad ripoffs: Ink-stained wretches of the world, unite!

https://t.co/k5ASdVUrC2

3/


Strength in numbers: The crisis in accounting.

https://t.co/DjfAfHWpNN

4/


#15yrsago Bad Samaritan family won’t return found expensive camera https://t.co/Rn9E5R1gtV

#10yrsago What does Libyan revolution mean for https://t.co/Jz28qHVhrV? https://t.co/dN1e4MxU4r

5/
FOR LATER READ
Outdoor Learning at Winsford High Street
Outdoor Learning at Wi...
@ODLHiStPrimary
The #worldwildlifeday2021 theme is Forests and Livelihoods: Sustaining People and Planet aligning with UN Sustainable Development Goals 1, 12, 13 and 15. So, what are the UN Sustainable Development Goals (SDGs) & how can children begin to learn about them & get involved ?

https://t.co/8ICvHxE9QL is easy & fun to follow for our smallest of people #EYFS. Early childhood is the perfect stage to introduce the core concepts of what it means to be a global citizen. For our reception & KS1 children please take a look at this fabulous free resource

https://t.co/tZx8UIS58Q Storytelling is a powerful communications tool and helps children remember lessons and virtues that they will use in everyday life. The idea is to simplify the lessons of the (SDGs) so young children can relate to – and better understand – the SDGs.

For older children here’s a board game that aims to help teach children around the world about the Sustainable Development Goals in a simple and child-friendly way

This is a lovely free book for children to enjoy flicking through themselves https://t.co/ScMbQCfpjl Elyx, the United Nations’ digital ambassador, uses various expressions and actions to help demonstrate the meaning of each Sustainable Development Goal.
FOR LATER READ
The Reckoning \U0001f4a5
The Reckoning 💥...
@sethjlevy
1/ The reality is that when Boehner and McConnell joined the Democrats in 2010, to thwart the impact of the tea party, they broke trust with the base.
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Thread: History of Mogadishu and it’s conquest by Imaam Al Yaqubi


One of the First Imaams of the Hiraab Imamate was Mohamed Ibn Imaam Ahmed ibn Imam Ahmed Ibn Imaam Mohamoud Ibn Imaam Cumar Halol Al Yacquubi (Abgaal) during the year 1097 hijri.


After the collapse of the Ajuuran Abgaal nomads from the interior had started moving to take over the strategic port town of Mogadishu which was then under the muzzafar dynasty. By the 1600s Abgaal warriors had captured the city and set up their base in shingaani.


Mogadishu at the time was a large and well known port town. The Abgaal clan taking over control allowed them to obtain political power and world wide recognition.


Under Imaam Yaqubi’s time in power it’s reported that French merchants had arrived at the port in 1701
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HISTORY
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प्रतिज्ञ...
@RamaInExile
#twitterArts
Arts are best form to Express thoughts & devotion. In All civilization Arts played very important role to express sprituality. Tibbeten Tangkhas are prime example .

List of My Paintings & Sketches


प्रलय पयोधि-जले धृतवान् असि वेदम्
विहित वहित्र-चरित्रम् अखेदम्
केशव धृत-मीन-शरीर, जय जगदीश हरे!!


छलयसि विक्रमणे बलिम् अद्भुत-वामन
पद-नख-नीर-जनित-जन-पावन
केशव धृत-वामन रूप जय जगदीश हरे


नंदसि यज्ञ- विधेर् अहः श्रुति जातम्
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क्षत्रिय-रुधिर-मये जगद् -अपगत-पापम्
स्नपयसि पयसि शमित-भव-तापम्
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Hermann Peterscheck
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For fun I made a Robinhood account. It took me 5 minutes to sign up, get approved and transfer funds for trading...

Here's some details... Read on.

...it took me another 5 minutes to get qualified for options.

If I share a sign up I get "free shares" and I can share as much as I want up to 500$ worth.

The main UI has a prepopulated "list" of stocks/crypto to watch and links to news.


Clicking a stock opens a "trade" button that looks like this.

Notice options is first, buy second.

Options took me to an approval process (which took about a minute) and now away I go trading Baba options.


Buying stock looks like this. It emphasizes fractional shares.
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Simon DeDeo
Simon DeDeo
@SimonDeDeo
So, today, for the first time in 25 (!) years of Apple, I downgraded. From the 2016 MacBook Pro to my 2013, which I had kept in a drawer...


It was pretty simple to do—Apple Time Machine backups let me do it with one click.

That first tweet captures, in two pictures, how badly Apple has “lost the plot” (to quote @wylieprof). On the right is the Apple MagSafe adapter, from 2013. On the left, what I had “upgraded” to.

Thanks, Apple! I really was nostalgic for worrying about yanking my computer off the table.

Oh and I really appreciated not knowing if my computer was charging. What was great was the little whoop sound you used, so that the speaker before me could be informed I was charging my laptop.
TECH