“When the snow lay round about, deep and crisp and even”

‘Good King Wenceslas’ is a rather odd carol. Who was Wenceslas, and why do we sing about him at Christmas?

#thread
⛪St Andrew's, Wood Walton, Cambridgeshire

#SuvenLife – Niche R&D play..very high risk and very high reward…key is right allocation…

Jazz Pharma was quoting around $0.5 in 2009, today its $150 and Mcap of $8.5 Bn on Nasdaq..almost 300x in 11 years. 80% of its total sales ($2.1 Bn) come from single drug Xyrem.

Axovant Lifescience, bought Alzheimer molecule from GSK, repackaged it and done phase-3 trials. Before starting the trials, the valuation was $2 Bn, just before announcing the data, it rose to $3 Bn. One of the leading broker put the target of $12 Bn if the trials succeeded..

but it failed in phase-3 trials. Current Mcap is $120 Mn…

This is R&D for New Chemical Entity (NCE)…very high risk and very high reward…

Brain-related illnesses, also known as CNS diseases, afflict more than 2 billion people worldwide. Diseases of the brain and mind range

from Alzheimer’s, dementia, epilepsy, migraine, multiple sclerosis, neuro infections, Parkinson’s, psychosis, schizophrenia and stroke to brain injuries and various mental disorders. The global market or CNS therapeutics is projected to reach $137.7 billion by 2025.

#SuvenLife has 1 lead molecule SUVN-G3031 in phase-2 trials which is similar to Xyrem but superior features, 3 molecules completed phase-1 trials and starting phase-2 trials and 11 molecules in pre-clinical trials. All are related to CNS which is growing and uncluttered market

@The_Rumpus is open for essay submissions until February 28, so here’s a #RumpusEssays thread in which our amazing editors share what they would like to see in submissions. Give them a follow and send your essay our way via @submittable

Features Editor @happiestwerther is “still (forever) in love with the researched essays that teach me something about a subject while I also learn about a narrator.” #RumpusEssays

Assistant Features Editor @sarahkasbeer would like to see “essays with unexpected engines / innovative structures / emotional and intellectual depth / good ole narrative tension.” #RumpusEssays

Features Editor @kaytaybayy: “I'd love to see essays that are imbued with kinetic energy. I don't care what they're about. Just sweep me into your experiences and thoughts. Compel me to shake my dust off.” #RumpusEssays

Asst Feat Ed @DJ_theoretical: "I’d love to read about that weird, niche topic you’re obsessed with. Your Pog collection, those ribbon candies that seemingly only grandmas buy, your new obscure hobby. Distract me from the horrible big picture with your hyperfixations."

2020 marks the start of the quantum dot revolution.

Completely ignoring the fact that "photocatalytic generation of reactive oxygen species (ROS) from quantum dots (QDs) has been widely reported."

Results: It was found that whereas singlet oxygen (1O2) was not produced by photoexcited QDs, superoxide anion(O2− )and hydroxyl radicals(OH) were generated by QDs, especially in the presence of a physiological concentration of electron donating agent including NADH.

Using cell metabolic activity assays and various probes of ROS generation, the formation of ROS in cellular environments was demonstrated.

Conclusion: Illumination of QD-treated cells and bacteria with light did affect viability. The above results, together with those of assays in the presence of various scavengers of specific ROS, indicate that the formation of ROS by QDs mainly proceeded via electron transfer.

Oregon Prison Report: Voices from the Inside

"The people that were suspected of organizing the hunger strike in April are currently in segregation under bullshit rule violations, being held illegally, having their outgoing mail seized, and are being refused their property...”

“...and yet still in segregation."

(Testimony from Critical Resistance PDX's (@CR_PDX) Write Them All Campaign)

Snake River Correctional Institution (SRCI) / November 17, 2020.

#ODOCKills #KateBrownKills #FreeThemAll

COVID-19

If you are reading this I'm probably in Segregation as we speak because the inmates aren't necessarily allowed to tell you this, a lot of my homies were transferred to a different prison or put in solitary confinement for saying what's been going on here.

Let me start off by saying that this prison is currently and will continue to be a Coronavirus hotspot. Almost for the past year it has been.

At the beginning of this pandemic, due to our childish president, this pandemic wasn't treated with the emergency, urgency, and caution it needed. As you know Snake River is almost 25 minutes away from Boise, Idaho (if you drive fast).

THREAD: My thoughts on the decision not to call witnesses. Please correct me if I'm wrong. This take is based on what I think I know, and there's much I don't know, but I do not understand why the dems didn't depose Rep. Beutler. Let's talk about the objections: 1/

First, many are saying it would drag this thing out and prevent Biden's agenda from moving forward. I don't see how that's possible. The senate had the votes to depose Rep. Beutler. We saw that with the 55-45 vote to allow witnesses. GOP can't filibuster that 2/

It would have taken probably a week to depose her and introduce her testimony into the senate record. The senate is scheduled to be in recess this week. The only thing a deposition of Beutler would have done is stopped the senate's vacation. 3/

Since everything would have been done in roughly a week, and the senate was scheduled for a week-long vacation, the deposition of Beutler wouldn't have delayed any of Biden's agenda. 4/

Next, many are saying Mitch threatened to filibuster Biden's agenda. That's also an empty threat. Cabinet confirmations require only a simple majority vote, and the Covid relief package is going through the budget reconciliation process so it's not subject to filibuster 5/