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#SuvenLife – Niche R&D play..very high risk and very high reward…key is right allocation…

Jazz Pharma was quoting around $0.5 in 2009, today its $150 and Mcap of $8.5 Bn on Nasdaq..almost 300x in 11 years. 80% of its total sales ($2.1 Bn) come from single drug Xyrem.

 Axovant Lifescience, bought Alzheimer molecule from GSK, repackaged it and done phase-3 trials. Before starting the trials, the valuation was $2 Bn, just before announcing the data, it rose to $3 Bn. One of the leading broker put the target of $12 Bn if the trials succeeded..
but it failed in phase-3 trials. Current Mcap is $120 Mn…

This is R&D for New Chemical Entity (NCE)…very high risk and very high reward…

Brain-related illnesses, also known as CNS diseases, afflict more than 2 billion people worldwide. Diseases of the brain and mind range
from Alzheimer’s, dementia, epilepsy, migraine, multiple sclerosis, neuro infections, Parkinson’s, psychosis, schizophrenia and stroke to brain injuries and various mental disorders. The global market or CNS therapeutics is projected to reach $137.7 billion by 2025.
#SuvenLife has 1 lead molecule SUVN-G3031 in phase-2 trials which is similar to Xyrem but superior features, 3 molecules completed phase-1 trials and starting phase-2 trials and 11 molecules in pre-clinical trials. All are related to CNS which is growing and uncluttered market
1. SUVN – 502
SUVN-502 has recently failed in phase-2 trials where it couldn’t meet the primary end points related to Alzheimer’s but sub group studies has revealed some interesting statistically significant and
potentially beneficial effects of masupirdine on cognition,
function and behavior, which can be useful for further studies in Dementia and Neuro-psychiatry. Suven is planning phase-2 studies for the treatment
of behavioural and psychological symptoms of dementia (BPSD). Market size for this could be $2 Bn for USA.
2. SUVN-G3031 (phase-2 to be completed by Mar-21)
This molecule addresses a rare disease – Excessive Daytime Sleepiness (EDS) – in narcoleptic patients

3. SUVN-D4010 (phase-1 completed)
This molecule works for better cognition and as an anti-depressant
4. SUVN-911 (phase-1 completed)
It addresses the biggest limitations of current major depressive disorder (MDD) therapeutics with rapid onset of action, no sexual dysfunction, and enhancement in cognition

Some of the listed companies on NASDAQ working in CNS, (though not
strictly comparable) are Denali therapeutics ($7 Bn) and AC Immune ($340 Mn)

There are two possibilities ahead. Either it can partner with any big pharma company or list itself in USA. In the first case, it can get upfront payment with milestone payments defined.
In 2018, Lilly and AC Immune announced licensing deal for few molecules where AC immune received upfront payment of CHF80 Mn and up to approximately CHF1.7 Bn in other potential development, regulatory and commercial milestones, and low double-digit royalties with Lilly

More from jeevan patwa

jeevan patwa
jeevan patwa
@jeevanpatwa
#chemicals surpassed #FMCG in valuations.. valuation range is 60x - 100x now. Chemicals will have much higher growth rate than FMCG for next 10 yrs
INVESTINGCSALS
jeevan patwa
jeevan patwa
@jeevanpatwa
#Suven – Journey of my first 50 bagger…

I bought #Suven first in Apr 2013 around Rs 20…today after almost 7.5 years, its Rs 1000 (Suven pharma 920 adjusted for bonus + Suven Life 80)..CAGR of almost 68% for 7.5 years. I am fortunate to hold it throughout the journey and

1/n

add on multiple occasions on way up. Like to share my experience in this thread for everyone’s benefit..

First time I bought because I like the management focus on R&D. It had chosen the most difficult therapeutic area in pharma which is CNS and it was investing the cash

2/n

flow it used to earn from CRAMS. It also used to write off all the R&D expenses in the P&L instead of capitalizing it in BS. That gave me lot of comfort about management quality.

I kept on adding as funds keep coming. I remember giving a public presentation on Suven in

3/n

Mumbai at one analyst meet in Nov 2017 when it was trading at Rs 160. There was a huge call option embedded at that time in the form of SUVN-502. That would have been the blockbuster molecule if succeeded with market potential of $10 Bn plus..result was due in Dec 2019,

4/n

I loaded around 250-300 knowing the value of CRAMS business itself is more than 300.

SUVN-502 failed in phase-II trials, stock was down 15% from 300 to 250 in a single day, I added heavily. it was largest allocation in my portfolio because I knew the value of CRAMS business

5/n
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jeevan patwa
jeevan patwa
@jeevanpatwa
#IBullreal results have no significance at this point. Key points to understand –

Debt reduction – Ibulllreal will be debt free at the time of merger with 650 cr coming from Mr Gehlot and 580 crs from land sale to Elan group. Embassy will have 3000 crs debt out of which 1500 cr

will be reduced through QIP and rest 1500 crs will come from collections next year. So merged entity will be zero debt company in FY23

Sales potential – Launched + planned projects have 18000 cr sales potential with 3400 crs of near completed inventory. Pending cost is 3900 cr

and sold receivables is 4224 crs. That means 9900 crs of cashflow to come in next few years from these projects. In addition, it is holding land bank of 3353 acres and 350 acres (42.5 Mn) for commercial development with potential annual rental of 4300 crs.

JV/JDA/DM potential – With solid track record and backing of institutional investors, Embassy can acquire multiple large value projects under JV/JDA/DM model which enhance its RoCE. One such project is Embassy Bayview in Juhu with net surplus of 500 crs (quite big)..
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jeevan patwa
jeevan patwa
@jeevanpatwa
#Lauruslabs new website for CDMO
https://t.co/8GsCECr9Wq

and biologicals
https://t.co/pBr3GKEi9G

Both are multiyear themes...
LAURUSLABS
jeevan patwa
jeevan patwa
@jeevanpatwa
#DeepakNitrite valuation is most attractive in the space...

growth will be most explosive in the space...
VALUATION , DEEPAKNITRATE , SPECIALITY CHEMICALS

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Shreyas Doshi
Shreyas Doshi
@shreyas
Why does Your Manager’s Manager (YMM) request a deck/doc during a meeting, says it’s urgent, and then doesn’t respond for days after you create & send it?

Or, why does YMM often respond with trivial feedback (e.g. formatting) & not substantive feedback?

Answers in this thread👇🏾

Have you set an entirely new password on a site & said to yourself: “surely, I’ll remember it becos this site is so important for me”. Have you then gone on to forget that password the very next week?

Me too.

The reason for YMM’s odd behavior & my password optimism is the same.

That reason is the Focusing Illusion, first described by Daniel Kahneman.

The Focusing Illusion:
Nothing in life is as important as you think it is while you are thinking about it.

When YMM asked you to create that doc as one of the follow up actions during the Product Review, YMM fell prey to the Focusing Illusion.

Trust me, YMM had no intention of making you do busywork.

YMM truly believed that it was very impt & urgent to create that doc & review it.

This was YMM’s conception of how much of their future time was appropriate to spend on the item for which they requested that doc (Item A):
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Remi_1111FR \U0001f438 \U0001f64c \U0001f54a
Remi_1111FR 🐸 🙌 🕊...
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[42c] I’M CALLING IT ANONS.

I'M CALLING THE DEATH OF QUEEN ELIZABETH II ON 12/27/2020

THREAD POSTED ON DECEMBER 14, 2020

DECEMBER 14, DEC 1+4, D5.

PART ##4 CHESS 4D
PART ##5 CHESS 5D

d4.d5 FaLL of THE QUEEN

[13] DAYS TO PROVE ME WRONG
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Sarang Sood
Sarang Sood
@SarangSood
THREAD ON IRONFLY

These days the most preferred strategy for option sellers due to improved margins is IRONFLY. It's essentially a short straddle with long strangle. Long strangle acting as 'WINGS', which help in capping the unlimited risk associated with a short straddle.(1/n)

You can also view the position as a combination of Cal & Put credit spreads, if that makes it more easy for you.

There are 3 important things to understand while trading this strategy:

1) Initial size of the Wings
2) Risk Management
3) Adjustments

(2/n)

Since we are selling an ATM straddle, the 1st question is how far our wings should be? Ideally i sell .50 delta straddle & buy .20 or .10 OTM strangle, depending on my view on volatility. So the distance of wings depends on the IV setup. Higher the IVs, greater the distance.(3/n)

If you don't understand greeks, then ideally with 30 days to expiry (dte), wings should be around 300pts either side. If your trading in weekly then it should be not more than 200pts. Higher the premiums, higher the distance as we have more cushion of theta. (4/n)

It is important to understand that we need to reduce the distance of wings with time so as to manage our RISK in gap openings or sudden volatile move. So for eg. if you started with 300pt wings with 30dte, the wings wouldn't give the same protection when there is 7dte. (5/n)
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Malcolm Yarnell
Malcolm Yarnell
@myarnell
As a scholar who has researched and written quite a bit about the Anabaptists, can we set a few things straight?

1. Baptists are not Anabaptists. Their history is theirs; ours is ours. We have similarities, but we are not them. We honor them by not using them for our purposes.

2. Not all Anabaptists were in Münster, and many if not most Anabaptists at the time were just as appalled as we are by the Münsterites. So please drop the tropes equating all Anabaptists with Münster. Informed and honest scholars are known by their right retelling of history.

3. The same truth applies to the other types of Reformation Radicals. There is a great difference between those who have become known as Evangelical Anabaptists on the one hand and Spiritualists, Rationalists, etc. on the other hand. Respect them as you also wish to be respected.

4. Yes, there were Anabaptists who toyed with various heresies, including Arianism, Socinianism, and Celestial Flesh Christology. But there were also many Anabaptists who affirmed, commented upon, and used the traditional Apostles’ Creed, Nicene Creed, and Athanasian Creed.

And if you want to do the honest research, you can also find a few heretical Roman Catholic Popes and more than a few heretical Anglicans, Presbyterians, Lutherans. and whomever else you want to talk about. Good historical theology doesn’t play favorites; it speaks the truth.
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GAVNet
GAVNet
@GAValueNetwork
Daily Bookmarks to GAVNet 02/16/2021
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Beautiful story of Shri Krishna, Mata Rukmini & Satyabhama which teaches the importance of Bhakthi.
Devotion is important than anything.
#bhakthi
🕉
Satyabhama, royal princess was very proud of herself. Rukmini was very humble, her devotion was pure to Shri Krishna.


One day, Rishi Narada( Kalahapriya) arrived in Dwaraka and met Sathyabhama. In between the conversation he hinted that Krishna exhibits affection more to Rukmini than her. Worried Sathyabhama asked what can should be done to gain Krishna's undivided attention.
@SriramKannan77


Narada asked Satyabhama to make a vow, that she will hand over Krishna to him as a slave, if she cannot trade wealth equivalent to Krishna's weight. Narada thus convinces Sathyabhama that Krishna will admire her for sacrificing all her wealth for him.


Sathyabhama was sure that she have enough wealth to balance Krishna.

She went to Krishna and told about her vow to Narada. Krishna patiently listened to her and accepted the challenge. Satyabhama arranged to bring large scales to weigh and brought all her precious jewels.


Krishna patiently sat on one plate of the Scales (tula). Sathyabhama started piling up the gold, jewels on the other plate. She kept adding more and more wealth, but the pan with Krishna did not even budge. Even after keeping all her jewels the scale did not move a little
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Savitri Mumukshu - \u0938\u093e\u0935\u093f\u0924\u094d\u0930\u0940 \u092e\u0941\u092e\u0941\u0915\u094d\u0937\u0941
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1/n
The kingdom of Sindh was ruled by its last Hindu king Raja Dahir during the 8th century. When Muhammad-bin-Qasim invaded Sindh, he decimated Sindh in his savage bloodlust. The chronicles of his advent are described in the Chachnama.


2/n
The Chachnama describes in detail how the Arabs led by butcher Qasim conquered Sindh. It tells the terrible tale of bravery, treachery, & carnage marking the entry of Islamic conquest of India’s Hindus.


3/n
When Muhammad-bin-Qasim attacked Sindh, Dahir had collected an army of 50,000 horses and marched from Brahamanabad to Rawar to face the invader. Qasim had an army that numbered in the tens of thousands with camels & horses.

4/n
Earlier Arab Alafis - Syeds from Prophet Mohammed’s own family had fled from Mecca with 500 men to Sindh and Raja Dahir had given them asylum. Trusting these Muslims would prove to be the fatal mistake for the downfall of Sindh & pave the way for Islamic invasion.

5/n
On an “auspicious day” in A.D. 711, fixed by astrologers, Mohammed Bin Qasim started for Sindh at the head of the Iraqi, Syrian, and other Arab soldiers. His horses and camels were disguised to look like lions and elephants. Rebel Jats also joined Qasim’s army.
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Filippo Valsorda
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“We don’t negotiate salaries” is a negotiation tactic.

Always. No, your company is not an exception.

A tactic I don’t appreciate at all because of how unfairly it penalizes low-leverage, junior employees, and those loyal enough not to question it, but that’s negotiation for you after all. Weaponized information asymmetry.

Listen to Aditya


And by the way, you should never be worried that an offer would be withdrawn if you politely negotiate.

I have seen this happen *extremely* rarely, mostly to women, and anyway is a giant red flag. It suggests you probably didn’t want to work there.

You wish there was no negotiating so it would all be more fair? I feel you, but it’s not happening.

Instead, negotiate hard, use your privilege, and then go and share numbers with your underrepresented and underpaid colleagues. […]
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Ryan Caldbeck
Ryan Caldbeck
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1/ I am seeing more and more founder secondary in venture rounds (Secondary = founders selling some of their shares before some other shareholders are able). Series B-D. I see both as an investor and through entrepreneur circles.

2/ I like secondary for entrepreneurs. Moderation is key but in a lot of situations I think it helps accelerate the co. Lots of very smart investors disagree. Here are my thoughts.

3/ Magnitude: My basic rule of thumb from what I see is market is 4+ yrs and up to 10% of founder’s equity stake with some $ cap that makes sense given stage etc. (typically <$10m)

4/ The entrepreneurial journey is brutally hard. Giving some financial relief helps remove one piece of pressure. I don’t think that secondary in the magnitude mentioned impacts the drive/persistence of great entrepreneurs.

5/ That secondary means they will be able to just sleep knowing they can pay their kids’ tuition. Secondary will make most founders better at their jobs, thus accelerating the co.
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Brianne Kimmel \U0001f4ac
Brianne Kimmel 💬...
@briannekimmel
Shocking fact: Millennial men are less likely to work than any other age and gender demographic in America.

Today, there are 500,000 young men missing from the U.S. workforce.

Research suggests video games & improved leisure tech plays a role in the problem. 👇 Thread:

Following the 2007 to 2009 recession, 25 to 34 year old men exited high school with fewer middle-skill job opportunities than years prior.

During this time, we saw an increased number of men living with parents & choosing unemployment over lower paying jobs.

It's estimated that 24M millennials live w/ their parents.

1 in 4 living in their parents’ home neither go to school nor work.

What's more surprising? 9 in 10 who lived with their parents a year ago are still living there w/ no plans to leave.

Economists are calling millennial men a lost generation.

According to economist David Dorn:

“If you get to the point where you’re turning 30, you’ve never held a real job and you don’t have a college education, then it is very hard to recover at that point.”

Economists suggest this choosiness is a generational trait.

Forbes interview w/ a high school educated man:

"I’m very quick to get frustrated when people refuse to pay me what I’m worth."
“People feel that they have choice nowadays, and they
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