#JPM2021 @GenapSys My Highlights: I think it's fair to say I am more excited than most about this #NGS company, as I see them as an example of how to enter the market while keeping a small profile ($249M raised so far).

They now are aiming at 2021 to ship two new chips: 50MM read chip and 144MM sensor chip (not sure what the difference is between read/sensor).

They show a slide of price per Gb with #Illumina products as a reference, and their products now lined up, I think, for the first time with price per Gb info. Lowest will be the 144MM chip at ~$27/Gb.

As their technology is closer to the #IonTorrent than to the cycle-by-cycle SBS-based sequencing methods, they should have microindel errors in their profile. These look much better, almost null, than the S5 data they show in comparison.

The next slide, also about error rates, either for each base as the run progresses or sliced in GC% windows, has a lot of info, but difficult to read. I think the summary is that the @Genapsys profile shows a bit of microindel error but otherwise comparable to 100bp ILMN data.

The Megaphone Report for Wednesday, January 13.

Today’s report is an Oxford University / AstraZeneca vaccine special. First - Australians deserve the most expensive of vaccines.

The purchase of the vaccine is compared to the NBN rollout and corruption is suggested.

Corruption was a running theme connected to the AstraZeneca vaccine purchase - especially in relation to D. Sharma.

Brand shopping was another theme, with demands that Australians must have the best.

The Cantillon Effect is the most important economic concept you’ve never heard of.

Here's a breakdown of what it is (and why you should care):

1/ Richard Cantillon was an Irish-French economist and philosopher born in the 1680s.

He achieved success as a banker—which he attributed to the formidable connections made through his family and employer.

At a young age, he had learned of the impact of proximity to power...

2/ Around 1730, Cantillon wrote a paper—Essay on the Nature of Commerce in General—which is considered a foundational work in the study of the political economy.

It was widely circulated in manuscript form, though it was not published until 1755, well after his death.

3/ In the paper, Cantillon posited that the early recipients of new money entering an economy will benefit more significantly than those it trickles down to.

In other words, the "flow path" of the new money matters!

4/ In 18th century terms, those closest to the King—the source of money/power—benefitted first when new money entered the economy.

Broadly, Cantillon observed that new money creates distributional effects based on where it enters the system.

The Cantillon Effect was born...

21 Financial Resolutions for 2021 (and 20 Things We are Leaving in 2020):

21 resolutions for 2021

Spend less than you make, period

Work with an advisor to get a formal financial plan

Own the world: diversify within and between asset classes

Splurge, but only infrequently to maximize happiness

Read at least one book per month

Invest in your mind and skillset

Spend money in ways that increase happiness: charitable giving and time with loved ones

Automate every part of your financial life

Teach someone else about the power of saving and investing

Learn to savor and appreciate what you already have

Save at least 1% more than you did last year

Check out your credit report

Declutter: get rid of everything you don’t use or love

Make a (realistic) budget

Track your net worth

Make one extra mortgage payment

Create a “vision board” with your three top financial goals

Make bite-sized financial goals with rewards for completion

Choose experiences over stuff

Rebalance at least yearly

Have fun and buy things that matter to you - you can’t take any of your money with you!

1/ This is a memo outlining 11 ways to hide your money offshore.

It was not supposed to “fall into the wrong hands.”

Well, it did. https://t.co/N6RUDqHVfR

2/ The “11 ways” memo is part of a huge trove of documents—350,000 to be exact—leaked from inside a trust company called La Hougue, based on an island off the coast of France.

Amid the data, this memo stood out for its candor.

3/ After one tax expert reviewed it, he told @SamEifling and @CalynShaw, “I have to say I’m not sure what else I can add other than ‘WTF’? (you can quote me on that). How stupid (or confident nothing will ever happen to you) do you have to be to put this in writing?”

4/ Mother Jones and @GlobalRepCentre are surfacing this particular memo simply because it’s the sort of thing you never see: a customer-facing document obtained in a big offshore data leak, quoting dollar amounts that few people ever hold in their hands at one time.

5/ Each of the 11 options listed in the memo offers some sort of contrived business deal by which you move money into an anonymous offshore account. And—here’s where the genius lies—they design those deals to give you some sort of tax break. The methods are, at best, legal-ish.

The Review: GW 21 - A thread

Hi everyone, welcome to the latest edition of “The Review” where I reflect on the happenings of GW 21 with a look ahead to GW 22:

#FPL #FPLCommunity @OfficialFPL

(Data taken from @FFScout and @FFH_HQ with consent)

I’d like to share that the Fantasy5 had another winner and have now paid out £20k within 5 days! It’s free to enter, a lot of fun and potentially very rewarding. All you have to do is to pick 5 players who you think will beat their predicted

At this point, I’d also like to mention that I post about FPL on my Instagram too, so if you have an Instagram account, follow up here!

Q: In this section, I analyze the impact of Harry Kane’s loss on Spurs attack.

I know the sample size is small but what’s worth noting is that Spurs have created just ∼0.48 xG in the 130 minutes of football played since Harry Kane has been injured. The eye test seems...

... to back this up – Spurs look lethargic and out of ideas and hence it is no surprise that they haven’t created a single big chance since Kane’s injury. Son was playing more centrally and was Spurs’ most advanced player on the field v Brighton...

1/11
The House of Reps approving $2000 relief checks rather than $600 dollars. That’s a big deal. $2000 checks could ease the pain just long enough for millions of Americans to remember this is the good our government can do in moments like these. #velshi

2/11
The bipartisan bill was met by Mitch McConnell at the front door of the senate with the words "The Senate is not going to be bullied into rushing out more borrowed money into the hands of Democrats' rich friends who don't need the help.” #velshi

3/11
The bipartisan bill for $2,000 checks was met by Mitch McConnell at the front door of the senate with the words, "The Senate is not going to be bullied into rushing out more borrowed money into the hands of Democrats' rich friends who don't need the help.” #velshi

4/11
What is, indeed, “rich” is Mitch McConnell - estimated to be around the 9th wealthiest person in congress - and who makes $193,000/yr, talking about people’s “rich friends”.
#velshi

5/11
If you add $2,000 to the $1,200 checks that went out in March, that’s $3200 over 9 months. $11.85/day. Nobody’s getting rich off of that. #velshi

1) We are short CleanSpark $CLSK. Our full report is now available at

2) CleanSpark $CLSK claims to be a clean energy software company which is "changing the face of energy markets globally." We think CleanSpark has habitually lied about its supposed customers and contracts, many of which we've found simply do not exist.

3) In August, $CLSK claimed "project deployments to be executed as part their exclusive [ILAL] agreement" to install microgrids for 252 homes in Valle Divino, Mexico. We visited Valle Divino and found an empty wasteland, emblematic of CleanSpark's promises to investors.

4) Similarly in January 2020, $CLSK touted a contract with Shoreline Schools, which analysts now estimate could lead to $3M in revenues. We simply asked Shoreline, whose rep told us that the plans contemplate just $300,000 worth of revenue, a mere 10% of these claims.

5) This is nothing new; $CLSK once claimed to have "designed a best in class microgrid solution" for Green Dragon, a cannabis operator. We again reached out to Green Dragon who told us, point blank, that no business was ever done and $CLSK fabricated it. We include those emails.

1/11) Introducing https://t.co/dDuU0rsw1Y.

We are building a new #DeFi asset management protocol.

Ccommunity owned and community managed funds.

DeFi meets Wall Street Bets.

It's time to decentralize and democratize investment

https://t.co/exErPi5VRn

TLDR 👇

2/11)

The investment landscape has changed forever.

We are finally at zero interest rates. End of the road.

Traditional asset classes like bonds or equities don't have risk/adjusted positive outlooks anymore.

Inflation looms 💸💸

What can we do about it?

3/11

As @RaoulGMI says, only one asset class has outperformed this increase in the money supply.

#Bitcoin, and crypto assets are just getting started.

Asset Management TAM is > $100T while DeFi is just $40B and all crypto is ~$1T.

Huge opportunity ahead 🚀🚀

4/11

We want to give everyone access to this one-in-a-lifetime opportunity.

Accreditation rules, access to secret deals and local jurisdiction have kept the best opportunities private.

@balajis said many times that Web 3.0 is going to turn the world into investors. We agree.

5/11
We need to give everyone a chance to participate.

Robinhood has made everyone aware of the risk of centralized platforms.

If you are not paying to use a platform, you are the product.

Thanks to #Ethereum and #DeFi, we can offer asset management that is trustless and open.

The truly violent nature of the US neoliberal bipartisan political establishment is revealed in its commitment to funding racist, militarized police forces above funding healthcare & housing. The same ones who scoff at “defund police” also scoff at funding universal healthcare 1/

They put immense energy toward maintaining a veneer of “civility” by wearing high-priced suits, adhering to a certain decorum with one another & engaging in performative governance. But their policies, words & actions reflect the truly violent nature of their character. 2/

These are people who see little distinction between property & human life, particularly the lives of the poor, nonwhite &/or marginalized. It’s not surprising—given that this is the value system of those who established the nation in the first place,... 3/

...that those most comfortable in the modern day establishment would share this same general viewpoint.

These are not individuals who oppose violence in principle but who instead want to monopolize the use of violence in their roles as gov’t officials & the political class. 4/

What ultimately made the Trump era disruptive to the bipartisan establishment wasn’t racism or violence—the establishment upholds both & he still enjoys support from the majority of Republicans and white voters—but that there was no veneer of civility. 5/

First they came for the 🐟

And John Redwood said the 🇬🇧 fishing industry would adjust

Then they came for the 🐖 farmers and 🐷 exports

And they said don't worry, it's just teething problems

Next they came for the 🦪 exporters

And there the Minister wrote a letter saying 🇪🇺 was wrong, when his officials knew 🇪🇺 was right

Then the 🧪 industries worried about the 💷 of making a new database to replace REACH

They're still waiting

The 🚛🚚 operators fear that a load of vehicles are returning to 🇪🇺 empty, and volumes are down

We do not recognise the numbers, the 🇬🇧 Government says

(1/14) The World Bank’s 2017 report titled ‘Precarious Drop’ pointed out how nearly 20 million Indian women were ‘missing’ from the workforce during 2004-2012.

(2/14) While media reports and headlines might have put the onus on women themselves, it is hard to ignore that there are many challenges that hinder women from rejoining the workforce post a career-break taken for several reasons, including childbirth.

(3/14) Out of those who manage to rejoin the workforce, many women eventually drop out in less than 6 months. This was due to “lack of awareness about inclusivity” in corporate offices in the ’90s, points out Dr Saundarya, someone who chose to be the solution to this problem.

(4/14) Having experienced all the challenges of a returning female professional, she founded Avtar in 2000, as a diversity and inclusion platform that helps women get a second shot at building their careers.

(5/14) And, recently, in November 2020, she expanded her focus through MyAvtar — a job portal for people from marginalised backgrounds, to include the LGBTQ+ community as well.

#AXXAers a short(ie #shortsqeeze hopefully) #update on one of $AXXA’s #VC companies:
1/

$AXXA Great #zoom call over the weekend w/our #French #VentureCapital Office. We received confirmation of a #USD $250,000 #INVESTMENT into one of our early-stage startups from a reputable international #VC funder.
(let's focusing on #VC before we move to other divisions)
2/

$AXXA Our #French #VC Group will be increasing its stake in this #startup. For confidentiality reasons, we will not disclose the name of the #funder until the second #stage #Funding round is complete.
3/

A little about #axxaVC: $AXXA #VC company invests in a range of technologies including #Robotics, Hardware, IT, #Health & #Biotech, and #VR and #AI technologies. These are areas where the direct application of technology makes a real, measurable difference in people's lives.
4/

$AXXA The #VC subsidiary company that just received its Second Round funding develops #Virtual #Reality (#VR), #Augmented #Reality (AR), and #Mixed #Reality (#MR) technologies. Their #technologies are cost-effective motion trackers for multiplayer full immersion #VR zones.
5/

Anyone have any opinions on how self-insured employers consider innovative healthcare offerings to pass on to their employees?

As I understand it, by shouldering the financial risk, self-insured employers can curate a list of more relevant benefits ... (1/10)

... thereby avoiding paying out lofty insurance premiums for services that its employees don't use or want. There seems to be a long list of intangible benefits having to do with talent acquisition and retention, but I'd like to understand the cost equations more fully. (2/10)

In the context of multi-cancer screening, I'm skeptical that it could be cost-saving for small or medium-sized employers (<500 employees). Assuming a representative sample of the population, there are simply too few cancers and too many false positives w/ expensive ... (3/10)

... diagnostic follow-ups to bend the unit-economics in the right direction. Indeed, for larger self-insured employers, maybe on the order of thousands of employees, the dynamics may change. Each true positive is a chance to save on treatment cost and (possibly) to ... (4/10)

... extend life. However, employers won't likely be able to distinguish between true life-extension and lead-time bias without prospective, randomized studies, which are due out in the 2024-25 timeframe. Still, these likely will include interim endpoints only. (5/10)

How @OthersideAI founders @mattshumer_ @MilesFeldstein and @JasonKuperberg amassed a 13k waitlist and $2.6m funding after building a demo in 2 hours.

Their product will change how we communicate. 👇🧵

2. OthersideAI was launched in the latter half of 2020 by three college-aged founders—Matt Shumer, Miles Feldstein, and Jason Kuperberg.

The company’s origin story is incredible. 🔥

3. The three founders met at @LaunchPadSYR (the Blackstone LaunchPad & Techstars at Syracuse University). 🎓

The idea for OthersideAI came from an experience CEO Matt Shumer had at his previous startup, Visos.

4. Without a network to tap into, Matt Shumer had to cold email practically anyone he wanted to connect with or pitch. 📧

“I eventually came to the conclusion that I spend too much time writing emails and I tried to figure out a way to use [GPT-2] to cut that time down” -MS

5. WTF is GPT-2? 🤔

Open-source artificial intelligence by OpenAI.

Developers wield the AI to perform certain specific tasks.

In this case, composing emails.

Jim Traficant US Bankruptcy FDR sold USA to the UN International Bankers IMF-

FDR was a Traitor who gave our Sovereignty to United Nations Banksters IMF under The Federal Reserve Act

Dissolving American Sovereignty and our Constitutional