Controversial 3D. Probably none of you knows about Leber congenital amaurosis type 10, congenital blindness that affects 3 out of 100,000 children, condemning them to blindness for life. The only possible treatment is through gene therapy. 1/n

Thanks to Crispr-CAS9 technology we MODIFY the defective gene inside the patient eye ( they directly inject the treatment into the eye). Before CRISPR the treatment was based on Adenovirus carrying the correct form of the gene

In both cases, we MODIFY the patient DNA and that's the only way (today) to treat this disease. LCA10 is not the only genetic disease affecting kids unfortunately the list is long and the variety of diseases is terrifying.

Now think about a parent with a kid with a genetic disease, he/she would try and do anything to save him/her. ANYTHING and they would take some RISKS, gene therapy was a risk at the beginning, and any new experimental treatment shares a percentage of risk. 4/n

Now we come to #COVID19 and #vaccines. The new RNA vaccines are a HUGE scientific breakthrough, that may open new amazing therapeutic paths. And like ANY other human activity share a risk.

This view that only government's can censor, that only state agents coming to your house and slapping something over your mouth counts as limiting free speech, really needs to be tackled.

The oddest part is that's it's generally the left which seems most content to let private companies wield extraordinary power over who can speak and how.

There are all sorts of legitimate reasons to limit free speech. Right now we are seeing one of them with Trump - to prevent incitement to violence and a threat to the functioning of democracy. But it is still censorship.

We need to be clear that that is what it is, rather than limiting our definition of censorship to the smallest range of actions conceivable.

This is not a new idea. Benjamin Constant, Harriet Taylor and John Stuart Mill were treating the silencing which comes from society as equivalent, or more dangerous, than that of the state hundreds of years ago.

#CentralAfricanRepublic (THREAD)

1) 200 to 300 rebels attacked the capital #Bangui today (PK9, PK11, PK12 & Bimbo areas).

Govt, #Russian & #Rwandan troops repelled them. But the rebels remain in the hills & areas surroundings the capital.

Read @CrisisGroup statement 👇

2) The rebels were generally equipped or light weapons (including #AK47 & grenades), several #RPG & probably mortars.

No report of the casualties yet.

3) It's unlikely that they really wanted to size the capital, if not they would have come in bigger number.

They seem to be trying to isolate the capital from the rest of the country that they already control largely & install an attrition warfare just at the capital doors.

4) Its not excluded they may also be trying to play with the psychology of the Constitutional Court which will proclaim the final results of the elections in the coming days.

5) One thing is sure, with the new offensive of the rebellion, including at the capital doors, it becomes more difficult, if not unwise, to organize the second round of the elections for National Assembly.

For some non-Covid news, and as a bit of recent political history, I’ve been released more than 100 pages of internal press office communications relating to the Home Office’s fried chicken box saga.

You may remember back in heady 2019 that there was an uproar after the government provided takeaway boxes with anti-knife crime messages to chicken shops around the country.

The campaign faced an immediate backlash, with critics questioning why fried chicken shops — stereotypically associated with young black communities — were being targeted by the Home Office for this campaign against knife crime.

The emails I’ve been released show that privately, officials admitted that the outcry risked angering the communities the campaign was trying to reach out to.

A briefing prepared by a Home Office official highlighted that they were “unsure what could be done publicly” to rebuff the criticism, and that the campaign’s focus on chicken boxes had created a perception that the campaign had “publicised racist stereotypes”.

Autism and meltdowns - what are they and how can you help?

A thread. Please read and share widely. As always, based on my own experiences.

#autism #autistic #Meltdown

Autistic people are stressed. *Very* stressed. Take it from me - our existence is generally peppered with moments of calm on a backdrop of continual tension and intense stress. The reasons for this are complex. /2

Our senses are often way too sensitive, meaning we live assaulted by intense sensory input - sound, vision, smell, touch and so forth. This means our base level stress is always much higher than most folks. /3

We are also usually struggling to make sense of social communication in a way neurotypical people don't need to worry about. Often we have to put actual brainwork into every interaction, as nothing seems to come naturally to us. Even with friends or loved ones. /4

So our glass of stress is very frequently filled to the absolute brim, and it doesn't take very much for us to spill over into a kind of 'post-stress' state, and I guess that's what we call meltdown. /5 #autistic

There were at least two insurrectionist plans that day.

As I’ve written previously, one of the plans was simply to either take Pence hostage or to assassinate him. 1/28

That was the more extreme plot, and it is an interesting question whether and to what extent Trump, Giuliani, some WH aides, and some nationalist insurrection members of Congress knew of the plan and either facilitated it or condoned it. 2/28

But there was another plan, less violent and extreme, but equally seditious, which we know was supported by a number of extremist members of Congress. It was also the plan that Trump and his personal lawyer Rudy Giuliani publicly espoused. 3/28

That plan was simply to ensure somehow, by force or by intimidation, that the certification of the election by Congress failed or fell short on January 6--the constitutionally mandated date for the final and determinative certification of the election. 4/28

The principal target here was VP MIke Pence. Pence had already announced publicly that he would not throw the election in the way that Trump had demanded because he lacked the statutory and constitutional authority to do so (which was, of course, perfectly true). 5/28

Ever heard of a temple where the statue of the Goddess was found in a field in 1936 after spending almost a millenia under the soil?And is worshipped as the Tri-Sakthi-Swaroopini?
No?
I shall narrate the story of Nidadavole Kota Satthema temple in West Godavari district, Andhra

Nidadavole is a sleepy little town in the district of West Godavari, located a few kilometres from the Godavari. Among other things, it is famous for its Gramadevatha and Kshetrapalika, the Goddess Kota Satthema

In the tenth century, Nidadavole was known as Nirvadhyapuram, and was under the rule of the Eastern Chalukyas. They were nominal feudatories of the Kakatiyas of Warangal. The local Sthalapurana indicates that the original temple was built by one king called Virabhadra.

This Virabhadra has been identified as the husband and royal regent of the Kakatiya Empress, Rani Rudramadevi who ruled Central Deccan during the period. The original stone figure of the Goddess was built within a fort during his reign.

The goddess was worshipped as the Shakti of the Fort. Over time the name entered the vernacular parlance as Kota (the telugu word for Fort) and Satthema (a local vulgarisation of the word Shakti).

Ian Wright of Food and Drink Federation says transport will get worse - trucks corssing short straits now about 2,000 - normally 10,000. Also Irish sea volumes very light, system not stressed but will be

Was Covid crisis a dress rehearsal for Brexit? Supply chais for food and medicines kept running. No, says Ian Wright, because there was no paperwork. Says Covid health checks at Dover was more of a dress rehearsal. Says backlog from that was still being cleared on NYE

Andrew Opie says Covid food supply was internal challenge, not external. Learnings from Dover: problem is often empty food lorries going back to Fr, ESP etc - about 1/3rd going back empty - being prioritised to keep food supply going

Stephen Kinnock MP says steel exports subject to quota - above quota tariff of 25% applies. Exports GB to NI count as part of export quota to EU (Port Talbot steel works in his constituency)

Phipson of Make UK says there are easements that could be put in place for steel and other matters but claims EU reluctant to do so for political reasons

An extensive yet super simple thread to understand the role of @RBI and how it uses 'Repo Rate' and 'Reverse Repo Rate' 👇🧵

You may bookmark this for further use.

#economy #RBI #financialliteracy

1. Let us first understand the role of Reserve Bank of India in managing the Indian economy.
There are two major elements of the Indian economy.

👉The Businesses:
They are the producers of the goods and services. Any business would be happy if it is growing and the prices of the goods and services sold are ever rising. They would be more interested in ‘Economic growth’.

👉 The Households: These are the people who are consumers and they spend the money to buy the goods and services which are sold by the businesses. Any consumer would be happy if the prices of the goods and services are low. Hence, they would be interested in ‘Less Inflation’.

2. As the prices of goods and services rise, there will be economic growth in nominal sense but then there will also be inflation which is perceived as a problem in developing countries like India.

How I went from being a broke college student making $1000/month to making multiple 6 figures online

Buckle in, it gets bumpy

My story - a thread:

Let's start way back

When I was 16 I was super into fitness

After school weights

Would sneak into the community 18+ gym

Had a garage bench press where my buddy and I would blast music and max out every day (lol)

This leads into my first online biz venture

2 years later, freshman year of college my other friend and I started a YouTube channel

We shot vids in the gym, did talking head vids on different topics, and did eating challenges

The most notable was a 10k calorie challenge that I have unlisted on my account

I'll show it to people at parties/get togethers because it is hilarious

Imagine stuffing your face with 10k calories

Super cringe, but hilarious

Safe to say that our YouTube channel venture died out pretty quickly

We didn't see a penny from it in the ~6 months that we did it

In my 2nd year of college I got into photography

I had the camera from when we filmed videos and decided to put it to good use

(I also took a few photo classes in high school so I wasn't diving in cold)

📦 FREE SCHOOL MEAL PARCELS EXPLAINED

🍏 I’ve had a number of questions today about the parcels that have been going out for those who receive free school meals and aren’t able to take up this entitlement in school at the moment.

🌽You may have seen photographs circulating on the internet showing a box of food that had been distributed by a contractor. It was claimed this had food in it that was meant to last ten days.

🧀 The food in the picture was actually only intended for 5 days, not 10, and cost £10.50 not £30 as has been suggested by some. The company responsible have however acknowledged that it could have been better.

🥕 The food is supposed to be a substitute for the lunch children would be missing in school - it’s not intended to be food for the whole day and it is not intended to feed the rest of the family either.

There are however other schemes available for struggling families who need this as part of the Covid Winter Plan.

TODAY I WILL BE SHOWING YOU HOW TO CONVERT YOUR PHYSICAL SKILL TO A DIGITAL PRODUCT. part A

People ask me one question over and over: What is a digital product? And why should an entrepreneur focus on digital products instead of just their physical counterparts?

What Is a Product?

A product is any item that you can sell to someone else in exchange for cash or barter. It could be a piece of produce, an electronic gadget, or a comfy couch.
Until the Internet altered commerce for the better, a product was always a physical object or item.

The virtual world has opened up a new category of products (which will get into later).
The point, however, is that a product is something you sell. Most often, you ask. for money in exchange for the product. That’s how you earn a living.

What Is a Digital Product?

A digital product is any product you sell online that doesn’t have a physical form or substance. You can’t hold a website theme in your hand, smell an e-book, or taste a software program — Uber eats does come close though ; ).

Why Are Digital Products Preferable to Physical Products?

You might wonder why you would offer digital products instead of creating your own physical product. After all, physical products dominated commerce for hundreds of thousands of years.

#PLEIADIAN COLLECTIVE

1. Friends Of Light!

It Is Difficult To Ignore All The Chaos And Hatred Around The Planet In These Moments!  This Is Where You Must Harness Intention And Become The Stillness Of Your Soul!

THE NOTICEABLE SIGNS OBSERVED ON IMPENDING DEATH(मृत्यु के संकेत या चिन्ह)

As per Skanda Puran, Kartikeya had narrated to Muni Agastya about the signs of the coming death. This is as per this ancient scripture.

If one experiences the air coming out of right nostril continuously then it is observed that the person dies within three years. If the breathing is continuous towards upper side from both the nostrils, then the person can die within two three days.

If the breathing is through the mouth instead of the nostrils then the person may live only for two days. The person should take into coignance these signs of the occurance of any sudden death.

As per astrology when the Surya is in the 7th house and Chandrama is in its own house and the breathing is only through the right nostril then the danger exists. If you see a yellow black coloured figure who becomes invisible immediately then the life span is limited to 2 years.

If any person sneezes, passes urine, stool and semen all together he has only a year more to live. If a person sees blue coloured snakes flying in the sky then he has only six more months to live. If a person sees any thing opposite to its real self like colours

A Thread On Reasons Behind
《Silence Of Ali(AS)After Saqifa》

○Role of Holy Prophet(PBUH)
1) The Holy Prophet had told Imam Ali: "Your position is like that of Ka'bah. People (Muslims) go to Ka'bah but that august House never approaches anyone. Therefore after my death, if people come to you and swear the oath of allegiance you accept it,

and if they do not come to you and swear the oath of allegiance, then you do not go to them."

Usudul Ghabah fi Tamizis Sahaba, Allama Ali ibn Muhammad, vol. IV, p.31;

2) The Holy Prophet had advised Imam Ali(a) that,"After me you will have to face severe sufferings, but do not

get disheartened and do not lose patience; and when you find people craving for and trying their utmost to secure worldly gains, you mould your life for the Hereafter." [59]

Madarijun Nabuwwah, Abdul Haq Muhaddith Dehlavi, vol. II, p. 511.

○Lack Of Companions
1)When Holy Prophet(PBUH) Told Imam Ali(AS) That People Will Go Astray After Him Then Imam Ali(AS) Asked Holy Prophet(PBUH) What Should he Do

2)In Rijal Kashi, It Is Mentioned That Only 3 Sahaba Were Present Before Zohr Prayer's and After That Ammar(RA) came