Check out our last preprint- We use single-cell & spatial technologies to map the human uterus and inform organoids experiments

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

We generate single-cell and spatial reference maps of the human uterus and dissect the signalling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments.
To study cell-signalling we use Cell2location (@vitaliikl) and develop CellPhoneDBv3 that considers cellular coordinates for the inference of cell-cell communication
We mapped 3D endometrial organoid cultures and benchmark the model to our uterine atlas. To do so, we develop a novel computational pipeline to align in vitro and in vivo datasets.
Our comparison highlights common pathways regulating the differentiation of secretory and ciliated lineage in vivo and in vitro.
Informed by the in vivo dataset, we show in vitro that downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively
We are excited about how our mechanistic insights of the healthy endometrium may help us understand neglected uterine pathologies, such as endometriosis or endometrial cancer
Amazing collaborative work with Turco lab @CamPathology @teichlab @bayraktar_lab led by amazing scientists @LuzGarAl @krobertssci @NikolKons & Louis-F Hanfield
A big thank you @MoffettAm485 for all fruitful discussions & help. Such an amazing journey!
Big thanks also @luiza_moore @KSaebParsy & many others for your guidance, discussions and sample acquisition.

More from Tech

The YouTube algorithm that I helped build in 2011 still recommends the flat earth theory by the *hundreds of millions*. This investigation by @RawStory shows some of the real-life consequences of this badly designed AI.


This spring at SxSW, @SusanWojcicki promised "Wikipedia snippets" on debated videos. But they didn't put them on flat earth videos, and instead @YouTube is promoting merchandising such as "NASA lies - Never Trust a Snake". 2/


A few example of flat earth videos that were promoted by YouTube #today:
https://t.co/TumQiX2tlj 3/

https://t.co/uAORIJ5BYX 4/

https://t.co/yOGZ0pLfHG 5/

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First update to https://t.co/lDdqjtKTZL since the challenge ended – Medium links!! Go add your Medium profile now 👀📝 (thanks @diannamallen for the suggestion 😁)


Just added Telegram links to
https://t.co/lDdqjtKTZL too! Now you can provide a nice easy way for people to message you :)


Less than 1 hour since I started adding stuff to https://t.co/lDdqjtKTZL again, and profile pages are now responsive!!! 🥳 Check it out -> https://t.co/fVkEL4fu0L


Accounts page is now also responsive!! 📱✨


💪 I managed to make the whole site responsive in about an hour. On my roadmap I had it down as 4-5 hours!!! 🤘🤠🤘
The chorus of this song uses the shlokas taken from Sundarkand of Ramayana.

It is a series of Sanskrit shlokas recited by Jambavant to Hanuman to remind Him of his true potential.

1. धीवर प्रसार शौर्य भरा: The brave persevering one, your bravery is taking you forward.


2. उतसारा स्थिरा घम्भीरा: The one who is leaping higher and higher, who is firm and stable and seriously determined.

3. ुग्रामा असामा शौर्या भावा: He is strong, and without an equal in the ability/mentality to fight

4. रौद्रमा नवा भीतिर्मा: His anger will cause new fears in his foes.

5.विजिटरीपुरु धीरधारा, कलोथरा शिखरा कठोरा: This is a complex expression seen only in Indic language poetry. The poet is stating that Shivudu is experiencing the intensity of climbing a tough peak, and likening

it to the feeling in a hard battle, when you see your enemy defeated, and blood flowing like a rivulet. This is classical Veera rasa.

6.कुलकु थारथिलीथा गम्भीरा, जाया विराट वीरा: His rough body itself is like a sharp weapon (because he is determined to win). Hail this complete

hero of the world.

7.विलयगागनथाला भिकारा, गरज्जद्धरा गारा: The hero is destructive in the air/sky as well (because he can leap at an enemy from a great height). He can defeat the enemy (simply) with his fearsome roar of war.