More from Casey Neistat
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(1) Some haters of #Cardano are not only bag holders but also imperative developers.
If you are an imperative programmers you know that Plutus is not the most intuitive -> (https://t.co/m3fzq7rJYb)
It is, however, intuitive for people with IT financial background, e.g. banks
(2)
IELE + k framework will be a real game changer because there will be DSLs (Domain Specific Languages) in any programming language supported by K framework. The only issue is that we need to wait for all this
(3) Good news is that the moment we get IELE integrated into Cardano, we get some popular langs. To my knowledge we should get from day one: Solidity and Rust, maybe others as well?
List of langs: https://t.co/0uj1eBfrYj, some commits from many years ago..
@rv_inc ?
#Cardano
(a) Last but not least, marketing to people with Haskell, functional programming with experience and decision makers in banks is a tricky one, how do you market but not tell them you want to replace them. In the end one strategy is to pitch new markets, e.g. developing world
(b) As banks realize what is happening they maybe more inclined to join - not because they would like to but because they will have to - in such cases some development talent maybe re-routed to Plutus / Cardano / Algorand / Tezos
If you are an imperative programmers you know that Plutus is not the most intuitive -> (https://t.co/m3fzq7rJYb)
It is, however, intuitive for people with IT financial background, e.g. banks
(2)
IELE + k framework will be a real game changer because there will be DSLs (Domain Specific Languages) in any programming language supported by K framework. The only issue is that we need to wait for all this
(3) Good news is that the moment we get IELE integrated into Cardano, we get some popular langs. To my knowledge we should get from day one: Solidity and Rust, maybe others as well?
List of langs: https://t.co/0uj1eBfrYj, some commits from many years ago..
@rv_inc ?
#Cardano
(a) Last but not least, marketing to people with Haskell, functional programming with experience and decision makers in banks is a tricky one, how do you market but not tell them you want to replace them. In the end one strategy is to pitch new markets, e.g. developing world
(b) As banks realize what is happening they maybe more inclined to join - not because they would like to but because they will have to - in such cases some development talent maybe re-routed to Plutus / Cardano / Algorand / Tezos
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Joe is the #1 / #2 podcast (depends per week) of all podcasts
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Independent and 100% owned by Joe, no networks, no middle men and a 100M+ people audience.
👏
https://t.co/RywAiBxA3s
Joe is the #1 / #2 podcast (depends per week) of all podcasts
120 million plays per month source https://t.co/k7L1LfDdcM
https://t.co/aGcYnVDpMu
Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs