@Iplaywithgerms This paper gives documentation on software (with causal reasoning, assumptions reviewed in appendix) for a parametric approach to estimating either "total effects" or "controlled direct effects" with competing events and time-varying
https://t.co/uRQcU1NqJd
https://t.co/kew3HltAev
https://t.co/RNhcgTBMkb
And here
https://t.co/rMWmwFBWwV
Others in reference lists of above papers.
https://t.co/uRQcU1NqJd
even when treatment is time-fixed, hazard ratios (whether cause-specific or subdistribution) do not quantify causal effects (even when counterfactual contrasts) except in special circumstances that will not hold in most studies
https://t.co/35OJDe8dD6
https://t.co/O08FNqPWWb
https://t.co/wKCrItvNhT
More from Software
The Great Software Stagnation is real, but we have to understand it to fight it. The CAUSE of the TGSS is not "teh interwebs". The cause is the "direct manipulation" paradigm : the "worst idea in computer science" \1
Progress in CS comes from discovering ever more abstract and expressive languages to tell the computer to do something. But replacing "tell the computer to do something in language" with "do it yourself using these gestures" halts that progress. \2
Stagnation started in the 1970s after the first GUIs were invented. Every genre of software that gives users a "friendly" GUI interface, effectively freezes progress at that level of abstraction / expressivity. Because we can never abandon old direct manipulation metaphors \3
The 1990s were simply the point when most people in the world finally got access to a personal computer with a GUI. So that's where we see most of the ideas frozen. \4
It's no surprise that the improvements @jonathoda cites, that are still taking place are improvements in textual representation : \5
The Great Software\xa0Stagnation https://t.co/A6peSPERaU
— Jonathan Edwards (@jonathoda) January 1, 2021
Progress in CS comes from discovering ever more abstract and expressive languages to tell the computer to do something. But replacing "tell the computer to do something in language" with "do it yourself using these gestures" halts that progress. \2
Stagnation started in the 1970s after the first GUIs were invented. Every genre of software that gives users a "friendly" GUI interface, effectively freezes progress at that level of abstraction / expressivity. Because we can never abandon old direct manipulation metaphors \3
The 1990s were simply the point when most people in the world finally got access to a personal computer with a GUI. So that's where we see most of the ideas frozen. \4
It's no surprise that the improvements @jonathoda cites, that are still taking place are improvements in textual representation : \5
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👨💻 Last resume I sent to a startup one year ago, sharing with you to get ideas:
- Forget what you don't have, make your strength bold
- Pick one work experience and explain what you did in detail w/ bullet points
- Write it towards the role you apply
- Give social proof
/thread
"But I got no work experience..."
Make a open source lib, make a small side project for yourself, do freelance work, ask friends to work with them, no friends? Find friends on Github, and Twitter.
Bonus points:
- Show you care about the company: I used the company's brand font and gradient for in the resume for my name and "Thank You" note.
- Don't list 15 things and libraries you worked with, pick the most related ones to the role you're applying.
-🙅♂️"copy cover letter"
"I got no firends, no work"
One practical way is to reach out to conferences and offer to make their website for free. But make sure to do it good. You'll get:
- a project for portfolio
- new friends
- work experience
- learnt new stuff
- new thing for Twitter bio
If you don't even have the skills yet, why not try your chance for @LambdaSchool? No? @freeCodeCamp. Still not? Pick something from here and learn https://t.co/7NPS1zbLTi
You'll feel very overwhelmed, no escape, just acknowledge it and keep pushing.
- Forget what you don't have, make your strength bold
- Pick one work experience and explain what you did in detail w/ bullet points
- Write it towards the role you apply
- Give social proof
/thread
"But I got no work experience..."
Make a open source lib, make a small side project for yourself, do freelance work, ask friends to work with them, no friends? Find friends on Github, and Twitter.
Bonus points:
- Show you care about the company: I used the company's brand font and gradient for in the resume for my name and "Thank You" note.
- Don't list 15 things and libraries you worked with, pick the most related ones to the role you're applying.
-🙅♂️"copy cover letter"
"I got no firends, no work"
One practical way is to reach out to conferences and offer to make their website for free. But make sure to do it good. You'll get:
- a project for portfolio
- new friends
- work experience
- learnt new stuff
- new thing for Twitter bio
If you don't even have the skills yet, why not try your chance for @LambdaSchool? No? @freeCodeCamp. Still not? Pick something from here and learn https://t.co/7NPS1zbLTi
You'll feel very overwhelmed, no escape, just acknowledge it and keep pushing.
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o