Modellers believe that spreading out our limited supply of vaccine as single doses for 3 months will save up to 6000 lives. One concern though is whether single doses might lead to 'vaccine resistance' through virus mutation. (1)

If we assume that over the next 12 weeks 12-20 million people get one dose of a vaccine and are told or believe it gives 90% protection what % will actually go for a second jab? We might assume second dose coverage is at best 70%. (2)
That means between 4 and 6.7 million people might have fading protection. Will the risk of creating a vaccine resistant mutant in this group of people, which could spread rapidly to 7 billion people around the world, outweigh the benefits of 6000 deaths prevented. (3)
I was initially reassured by a paper sent to me by an eminent virologist. https://t.co/UyTQZ0CFsW (4)
Essentially vaccine resistance is rare compared with drug resistance, first because multiple mutations are needed unlike for drugs, and second because vaccines tend to keep pathogens from ever achieving large population sizes within hosts. (5)
Nonetheless, vaccine resistance has been found with hepatitis B, whooping cough (B.pertussis, Strep. pneumoniae and other viruses, although these strains may die out through low transmissibility. (6)
Now I've read an excellent thread on the topic by a paediatrician and evolutionary geneticist. He refers to a study where the virus needed only 3 mutations to escape death from plasma full of neutralising antibodies. https://t.co/F5niMgZtlI.
He concludes: "The longer SARS-CoV-2 is in circulation, + the greater the number of people infected, the more of a chance escape mutants will have to form...and imperil the unprecedented efforts put into vaccine development". (7)
I've also been sent another highly technical paper about Covid mutations. https://t.co/5mzevEUh40 (8)
The paper concludes that "Widespread transmission of an emerging pathogen, such as SARS-Cov-2 can potentially lead to further mutations that affect transmissibility or effectiveness of countermeasures." (9)
The take home message is that where transmission remains high, viral mutations are more likely, which could change transmission rates, virulence or induce vaccine resistance. (10)
Giving single doses of vaccine might be fine in China, Taiwan or Norway, or any of about 70 countries with low transmission rates. But up to three million people in the UK may be infected, so the risks of mutations and vaccine resistance are much higher (11)
We've already seen a variant which appears to increase transmission by 50% or more. The difficult choice is between saving 6000 lives with a single shot policy and the risk of creating a vaccine resistant variant that could quickly cross borders. (12)
Whatever we decide, the message is that suppression of the virus must be at the centre of national strategy, not 'flattening the curve' which has, bizarrely, been official UK policy and advice since February 2020. (13)

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Brief thread to debunk the repeated claims we hear about transmission not happening 'within school walls', infection in school children being 'a reflection of infection from the community', and 'primary school children less likely to get infected and contribute to transmission'.

I've heard a lot of scientists claim these three - including most recently the chief advisor to the CDC, where the claim that most transmission doesn't happen within the walls of schools. There is strong evidence to rebut this claim. Let's look at


Let's look at the trends of infection in different age groups in England first- as reported by the ONS. Being a random survey of infection in the community, this doesn't suffer from the biases of symptom-based testing, particularly important in children who are often asymptomatic

A few things to note:
1. The infection rates among primary & secondary school children closely follow school openings, closures & levels of attendance. E.g. We see a dip in infections following Oct half-term, followed by a rise after school reopening.


We see steep drops in both primary & secondary school groups after end of term (18th December), but these drops plateau out in primary school children, where attendance has been >20% after re-opening in January (by contrast with 2ndary schools where this is ~5%).
Imagine if Christians actually had to live according to their Bibles.


Imagine if Christians actually sacrificed themselves for the good of those they considered their enemies, with no thought of any recompense or reward, but only to honor the essential humanity of all people.

Imagine if Christians sold all their possessions and gave it to the poor.

Imagine if they relentlessly stood up for the widow, the orphan, and the foreigner.

Imagine if they worshipped a God whose response to political power was to reject it.

Or cancelled all debt owed them?

Imagine if the primary orientation of Christians was what others needed, not what they deserved.

Imagine Christians with no interest in protecting what they had.

Imagine Christians who made room for other beliefs, and honored the truths they found there.

Imagine Christians who saved their forgiveness and mercy for others, rather than saving it for themselves.

Whose empathy went first to the abused, not the abuser.

Who didn't see tax as theft; who didn't need to control distribution of public good to the deserving.

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I just finished Eric Adler's The Battle of the Classics, and wanted to say something about Joel Christiansen's review linked below. I am not sure what motivates the review (I speculate a bit below), but it gives a very misleading impression of the book. 1/x


The meat of the criticism is that the history Adler gives is insufficiently critical. Adler describes a few figures who had a great influence on how the modern US university was formed. It's certainly critical: it focuses on the social Darwinism of these figures. 2/x

Other insinuations and suggestions in the review seem wildly off the mark, distorted, or inappropriate-- for example, that the book is clickbaity (it is scholarly) or conservative (hardly) or connected to the events at the Capitol (give me a break). 3/x

The core question: in what sense is classics inherently racist? Classics is old. On Adler's account, it begins in ancient Rome and is revived in the Renaissance. Slavery (Christiansen's primary concern) is also very old. Let's say classics is an education for slaveowners. 4/x

It's worth remembering that literacy itself is elite throughout most of this history. Literacy is, then, also the education of slaveowners. We can honor oral and musical traditions without denying that literacy is, generally, good. 5/x