OK winger wonderland story time boys & girls.

1. Sleet stops, it's warming up, neighbor decides get out & drive, probably after seeing some truck drive down our residential road (4-wheel drive). Neighbor has new SUV push button start, 2-wheel drive, which is NOT THE SAME THING.

A man just said “WHAT IS THAT?”when I walked by and then quickly yelled “IT WAS A COMPLIMENT” and then a small child said, and I quote, “Uncle Joe you can’t say that to ladies.” This boy will one day lead us all to greatness as a nation.

This is the second time in a month some dude has said something to me on the street and been shut down before I even said a word. Granted the LA version was more polite than when an NYC dude told me to smile and a lady cursed him out. People are hilarious.

I wouldn’t have been rude to either dude but wow, I didn’t even have to make the choice because we Americans are chatty.

Also I’m worried about Uncle Joe because $10 says his sister is the boy’s mom and we now know she’s not afraid to tell guys what to do.

My eyes got SO BIG and I almost laughed and Uncle Joe said, “That’s fair, my dude” to this kindergartener and I was like oh God the children will lead us.

I've been wanting to write this thread for a while. It has been inspired by hearing a common thought: why can't people just "listen"? If people just followed the rules, we wouldn't be in this mess. I think this is oversimplification of the problem with COVID: 1/

It is true, there are people who haven't been following guidelines (by definition that happened a LOT at Christmas/NYE in my region), but even before, we know transmission in private gatherings happens. 2/

These private gatherings are pictured to be big raucous parties, but in reality, even before lockdown, this is just people having dinner, watching TV, doing things we did before on a daily basis. These little ripples when added across the country make a big wave.. 3/

...and little can be done about this apart from positive messaging. You can't very well have police patrolling neighbourhoods across the country. 4/

Next thing is we keep hearing over and over and over, stay home. There are diminishing returns with this advice, but also, most people who can stay home ARE. So what's the issue? There are a HUGE # of people who can't stay home because they work in essential jobs 5/

So, I want to talk about how sexual harassment and fair pay are linked at Google (and beyond), because I think that's an angle that isn't being highlighted enough in the coverage of these walk-outs. I'm going to frame it largely around my personal experience there. Thread.

When I was sexually harassed by the director of the area I was working in, I was afraid to report it because I was worried that "getting him in trouble" would result in the subtle retaliation of missed leadership opportunities.

I wanted to continue working on the team I was on, because I'd gained a lot of very deep knowledge and expertise in that area, as well as reputation and camaraderie with the other folks working in that area. I didn't want to make the situation more "difficult."

To get promoted at Google, several need to happen: 1. you need opportunities for ownership and leadership above your current level (basically, opportunities to show you're working at the next level you're trying to get promoted to). The work you're "assigned" has a big impact.

2. You need glowing reviews from peers, *at or particularly above the level you're hoping to get promoted to.* Basically, you need people a lot more senior than you to say you're doing awesome work.

When I was 25, I worked as a legislative assistant in the Missouri General Assembly.

It was a dream job, honestly.

But that dream dissipated the day the #MoLeg decided to name Rush Limbaugh as an “honorable Missourian” and place his bust in the “Hall of Famous Missourians.”

1/

The Hall of Famous Missourians sits in the Missouri State Capitol.

There are busts of Mark Twain, Dred Scott, Josephine Baker, Harry Truman and other legends of history.

The day I learned Rush Limbaugh would join their ranks, I thought it was a joke.

2/

We received phone calls from constituents appalled that Missouri would honor a man who had become infamous that year for calling a college student a “slut.”

And who just that week had continued spreading the racist birtherism lie about our then-President, Barack Obama.

3/

What I learned that day is that it wasn’t *despite* his racism, but because of it that he received this award.

It’s because he created a universe where it was permissible to lynch with language America’s first black President.

4/

Several State Representatives and their staffers intended to protest the vote and the selection.

By the time we made it to the doors of the House Floor, we weren’t allowed in. It was Republicans only. The doors were locked and secured by the Highway Patrol.

5/

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10