BC HEALTH
Saved by @Mollyycolllinss

All my random ass behavior threads in one place🥲

 On power and power drunks
https://t.co/pPsqjA55mQ
Why we're weird about wiggles
https://t.co/cCvwsjbYJm
Empathy and petty dick gifts
https://t.co/6ZcaajizXW
Hypocrisy and hypocrites
https://t.co/hlxE9x7goD
Trash pathways
https://t.co/paQrZtxrQa
I KNOW AT LEAST ONE MEME
https://t.co/dbRkz7sj9t
Our heads are smol
https://t.co/bGftxIABwd
Behavior addictions and substance addictions, why they're different, and why they suck
https://t.co/Q2qKWBS0Ml
Cognitive rigidity vs cognitive flexibility
https://t.co/xFjbfUGlWl
The neurochemical process of romantic attraction and why it's terrible.
https://t.co/j5rNMmEnS2

More from Health

Nick Hinton
Nick Hinton
@NickHintonn
A Conspiracy Thread: The Sentient World Simulation


In 2007, the Department of Defense worked with researchers at Purdue University to create SEAS, or the Synthetic Environment for Analysis and Simulations. SEAS uses data from the internet to create realistically detailed models of the world which are used to predict the future.


We’re told SEAS is now capable of running real-time simulations of up to 62 nations and that it’s been used by Fortune 500 companies for strategic planning, or in other words, manipulating the market. Nevertheless, there are plans to turn SEAS into something even more advanced.


Developers say their goal is to turn SEAS into a Sentient World Simulation, or a “continuously running, continually updated mirror model of the real world.” However, some conspiracy theorists claim the SWS is already live and running inside a network of quantum computers.


Researchers like Seth Lloyd have suggested that the entire universe could be simulated inside a quantum computer. According to Geordie Rose, the co-founder of D-Wave Systems, a company that creates these machines, they can even tap into parallel worlds and other dimensions.
HEALTH , ALL
Eli Tyre
Eli Tyre
@EpistemicHope
I know some people who seem (to me) more concerned with receiving VALIDATION for their mental health issues than solving them.

They seem to care most about other people BELIEVING their problems are real.

I'm curious about this.

Like, it's more important to them that people know how debilitating their anxiety is, than to overcome the anxiety.

Or it's important to them that others believe that they're actually depressed, not "just sad."

Or they want people buy into the narrative that they've been traumatized, and might be something like offended if someone minimizes that.

What do we make of this?

1. One possibility is that if solving the problems seems hopeless or even just really hard, you need external support to be able to cope.

If no one cuts you slack because of your mental health stuff, maybe you're in a really bad place, so you need people to believe you.
HEALTH
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Tony Breu
Tony Breu
@tony_breu
1/16
Why do B12 and folate deficiencies lead to HUGE red blood cells?

And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?

For answers, we'll have to go back a few billion years.


2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.

Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine

But why does DNA contains thymine (T) instead of uracil (U)?

https://t.co/XlxT6cLLXg


3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).

In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?

https://t.co/bIZGviHBUc


4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.

DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.

https://t.co/bIZGviHBUc


5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.

When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.

[*Note: thymine is the base in dTMP]

https://t.co/AnDUtKkbZh
HEALTH , PATHOPHYSIO
Pete Wharmby
Pete Wharmby
@commaficionado
Once again I'm reminded that every action has an equal and opposite reaction. The recent push by a large number of autistic people to 'own' their diagnosis and try to raise acceptance and dispel harmful myths has kicked up a minority of autistic people to fight against this.

This may seem bizarre - who fights against improved acceptance? - but actually has clear roots in the ongoing culture war the West seems engaged in. The identity positive autistic movement, of which I am a part, is viewed by some as another manifestation of 'wokeness'.

This is the right-wing definition of 'wokeness', of course - ie a modern equivalent of the pejorative take on political correctness, but it's definitely at the core of this 'neurorealist' movement - the idea the autistic community is being hijacked by 'woke lefties'.

They believe that the push for acceptance of neurodiversity and rejection of the medicalisation of autism is misguided and drawing attention away from those autistic people who, in their view, need more help and intervention.

The trouble is, this view is pretty much baseless. Firstly, there is little evidence that autistic advocates who push for acceptance are in any way harming autistic people who require more help and support. Second, the view effectively silences those of us who are able to share.
HEALTH
Dylan Burnette
Dylan Burnette
@MAG2ART
Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
1/13
A thread based on Figure 1

A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13


Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13


Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13


The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
HEALTH

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Ottoman History Podcast
Ottoman History Podcas...
@OttomanHistory
Here is a special thread introducing our series on “The Making of the Islamic World.” It offers 10 episodes about the transformation of Islamicate societies between the 7th and 17th centuries. You can find the series page here: https://t.co/7mL9eWmMmz


This is Chris Gratien posting. I created this series during Fall 2020 for my students as asynchronous material supported by readings and discussion. This is going to be a long thread, but it will be a great shortcut for those looking to make similar use of these materials.

There are two items worth pointing out: 1. This is an overview of the political, social, and cultural history of Islamicate societies. It does not deal with the origins of Islam or many theological questions. It does discuss Islam’s spread and the transformation of Islamic law.

2. This is the first part of a two-part sequence that takes the history of the Islamic world into the present. It emphasizes developments and themes that have particular relevance for later periods.

This is really a multivocal narrative of Islamic history. We feature over 20 scholars from almost as many institutions. Many of those who worked on it, myself included, study the early modern and modern era but have teaching obligations that take us further back in history.
RELIGION
Zena Hitz
Zena Hitz
@zenahitz
I just finished Eric Adler's The Battle of the Classics, and wanted to say something about Joel Christiansen's review linked below. I am not sure what motivates the review (I speculate a bit below), but it gives a very misleading impression of the book. 1/x


The meat of the criticism is that the history Adler gives is insufficiently critical. Adler describes a few figures who had a great influence on how the modern US university was formed. It's certainly critical: it focuses on the social Darwinism of these figures. 2/x

Other insinuations and suggestions in the review seem wildly off the mark, distorted, or inappropriate-- for example, that the book is clickbaity (it is scholarly) or conservative (hardly) or connected to the events at the Capitol (give me a break). 3/x

The core question: in what sense is classics inherently racist? Classics is old. On Adler's account, it begins in ancient Rome and is revived in the Renaissance. Slavery (Christiansen's primary concern) is also very old. Let's say classics is an education for slaveowners. 4/x

It's worth remembering that literacy itself is elite throughout most of this history. Literacy is, then, also the education of slaveowners. We can honor oral and musical traditions without denying that literacy is, generally, good. 5/x
CULTURE
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Patrick Chovanec
Patrick Chovanec
@prchovanec
I'm going to do two history threads on Ethiopia, one on its ancient history, one on its modern story (1800 to today). 🇪🇹

I'll begin with the ancient history ... and it goes way back. Because modern humans - and before that, the ancestors of humans - almost certainly originated in Ethiopia. 🇪🇹 (sub-thread):


The first likely historical reference to Ethiopia is ancient Egyptian records of trade expeditions to the "Land of Punt" in search of gold, ebony, ivory, incense, and wild animals, starting in c 2500 BC 🇪🇹


Ethiopians themselves believe that the Queen of Sheba, who visited Israel's King Solomon in the Bible (c 950 BC), came from Ethiopia (not Yemen, as others believe). Here she is meeting Solomon in a stain-glassed window in Addis Ababa's Holy Trinity Church. 🇪🇹


References to the Queen of Sheba are everywhere in Ethiopia. The national airline's frequent flier miles are even called "ShebaMiles". 🇪🇹
CULTURE
George Mack
George Mack
@george__mack
THREAD: 15 of the most useful razors and rules I've found.

Rules of thumb that simplify decisions.

Bezos' Razors:

• If unsure what action to take, let your 80-year-old self make it.

• If unsure who to work with, pick the person that has the best chances of breaking you out of a 3rd world prison.

Skinner's Law:

• If procrastinating on an item, you only have 2 options:

1. Make the pain of not doing it greater than the pain of doing it.

2. Make the pleasure of doing it greater than the pleasure of not doing it.

Luck Razor:

• If stuck with 2 equal options, pick the one that feels like it will produce the most luck later down the line.

I used this razor to go for drinks with a stranger rather than watch Netflix.

In hindsight, it was the highest ROI decision I've ever made.

Bragging Razor:

• If someone brags about their success or happiness, assume it’s half what they claim.

• If someone downplays their success or happiness, assume it’s double what they claim.

The map is not the terrain.
ALL , BUSINESS , PRINCIPLES
Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
IT WAS RISHI KANADA WHO GAVE THE ATOMIC THEORY & TALKED ABOUT THE GRAVITY OF EARTH, 2600 YEARS BEFORE AN APPLE FELL IN FRONT OF NEWTON'S EYES:

Scientists of the modern world credit an English scientist John Dalton (1766 CE -1844 CE) for the Atomic Theory.


And this is because, most of us are not even aware of an ancient Indian Sage named Kanada, who was the first to formulate the theory of atoms, almost 2600 yrs before Dalton and talk about earth's gravity.


Rishi Kanada was born around 600 BCE in Dwarka, Gujarat and he was the son of a philosopher named Ulka. He was fascinated with the minute detailing of the things right from his childhood. Once, when he was very young, he accompanied his father on a journey to Prayaga.


He saw plentiful grains scattered along the path leading to the shore of river Ganga. It's a tradition in Hindu families to scatter the grains for the ants and birds to feed on them. Suddenly, an ant caught his attention, who was feeding on a rice grain.


He was mesmerised by this very fact that how a small grain of rice becomes food for the ant but to satisfy the hunger of a person so many grains are needed together. This incidence made him realize the importance of a single grain of rice.
ALL