1/ The classic presentation at morning report for hypercalcemia starts with polyuria, constipation and confusion. #UncleBob wanted to understand why - stimulated by @CuriousClinPod ? @HannahRAbrams @tony_breu @AvrahamCooperMD

NEW—CDC was truly suffocated by Trump WH at every turn. Kyle McGowan, a former chief of staff at CDC, and his deputy, Amanda Campbell, witnessed WH dismissal of science, WH’s slow suffocation of CDC’s voice, meddling in messages & siphoning of CDC budget.
https://t.co/HeuNbUggiw

2) ““Everyone wants to describe the day that the light switch flipped—It didn’t happen that way—more of like a hand grasping something, and it slowly closes, closes, closes, closes until you realize that, middle of the summer, it has a complete grasp on everything at the CDC”

3) “Mr. McGowan and Ms. Campbell, both 34, say they tried to protect their colleagues against political meddling from WH and HHS but was largely stifled by the Trump administration.

4) “The White House insisted on reviewing — and often softening — the C.D.C.’s closely guarded coronavirus guidance documents, the most prominent public expression of its latest research and scientific consensus on the spread of the virus.”

5) “The documents were vetted not only by the White House’s coronavirus task force but by what felt to the agency’s employees like an endless loop of political appointees across Washington.
Mr. McGowan recalled a White House fixated on the economic implications of public health.

New Cannabis Based Menu for Chao Phraya Hospital patients (service being rolled out to other hospitals too)
"This cannabis special menu is bringing different parts of the cannabis plant to use with leaves to cook as ingredients in food" #cannabis #Thailand

Whilst patients in the UK are still being denied with almost no progress with #NHS Amazing to see how much progress is being made with #cannabis as #medicine in #Thailand is the same 2 year period:

A Thread: 1/10 #Thailand allowed #cannabis #medicine in Jan 2019, 2 months after the UK.
NOW:
Is approved for 160+ conditions (everyone!)
Village doctors, clinics and hospitals can supply approved products or grow and produce their own, from nearly 100 approved formulas

2/10 - Average monthly prescription cost is £20-£30.
Educational programs started for the Medical Profession within 3 months, for many others at 6 months and school kids after a year. (Google Dr Ganja - see photo)

3/10 - Shortly they will launch a new policy for any individual or collectives to grow #cannabis for #medicine for themselves and any surplus material can be sold to the government for use in centralised production.

It's Monday AM post-@ASCO #GU21 & clinic starts in a couple of hours! Lots to process - I'll try to tackle optimal 1L tx for #kidneycancer. I'll make a case for cabo/nivo, leaning on the beautiful (& timely) tables below from @lalaniMD, @SoaresAndrey & @brian_rini (1/15)

What about IO/IO? We have long f/u w #CM214 data w nivo/ipi, no doubt (@AlbigesL et al in @myESMO Open). And treatment-free interval discussed by McDermott @BIDMChealth is no doubt impt. But we've known data not as impressive for favorable risk (2/15)

And furthermore, as @ERPlimackMD points out in another tweet, impt to look at primary PD rates (seen in @lalaniMD's table) - nivo/ipi at 19%!!! CR rate used to be something we highlighted w nivo/ipi, but now comparable across studies (3/15)

Okay now to the really tough stuff - comparing TKI/IO regimens. Something interesting I will add to @brian_rini @uromigos table above is the HR for PFS by INVESTIGATOR review. If the diff in HR for PFS by IND review caught your eye, this is even more striking (4/15)

I think INV-assessed PFS is impt, but if you're a skeptic, forget that argument. Turn instead to #QOL with axi/pembro. Kudos to @brian_rini @tompowles1 @ERPlimackMD et al for advocating for QOL in KN-426. @crisbergerot et al have taughts us the importance of these metrics. (5/15)

half of this website believes that all of your problems can be solved by going to therapy

another half thinks that the entire psychological profession is fake and after some vaguely construed revolution mental health will be solved

what's funny about this is that nothing about it new

I wish this wasn't paywalled because the books Lasch reviewed (in 1976!) sound very familiar. The same kind of dumb debates on this subject that occur constantly here are inherited from boomers

the point Lasch makes towards the end is that all of these books are grasping towards something that neither therapy or politics fully covers, even if both are obviously relevant.

but first, he does a tour through the books. he encounters people who believe all character traits are a product of "propaganda" and "conditioning" that can be fixed with therapy or therapy-like processes, and people who think therapy is a distraction from politics