Meanwhile, a few days ago the EMA published its EPAR (public assessment report) on the Moderna vax (HT @pajz_) https://t.co/LHW4rGgFwV It's 169 pages ...1/n

...There was "a major objection" to the US manufacturing sites, so they were withdrawn. Complete transfer for Europe to Swiss manufacturing due to conclude soon. (There have been Qs in the US about a batch there https://t.co/g573j7uFNQ)...2/n
...If you're interested in the chemical & biological aspects of this vaccine, there are pages for you to dig into - not an area I have any expertise in. Small amount of detail of reproductive toxicity study (in rats): no cause for concern....3/n
...The clinical trial data is from November, as for the FDA data. There's more detail than in the FDA report, though, of the phase 2 study, which hasn't been published. 600 people: a lot of data on immunogenicity (but not cell-mediated immunity)...4/n
...More methodological data on blinding etc for the phase 3 trial & *a lot more data* than in the FDA report. And take a moment to appreciate this: 30,000 people enrolled in less than 3 months. Giant thank you's due all round ...5/n
...In my posts, I've pointed to FDA report someone with apparent severe Covid-19 not adjudicated or in Moderna's analyses. Now we know why: no cases before dose 2 & not all suspected ones were adjudicated. That's not reassuring, though they conclude "no substantial bias" ... 6/n
...Like FDA, EMA point to person with severe Covid-19 in the vaccine group. Overall, data on severity reassured them, but "the cases overall seem mostly mild, which is a limitation of the dataset". "No definitive conclusion on clinical efficacy after one dose can be drawn" ...7/n
...They also conclude the definition of severe Covid-19 "could have been more stringent from a clinical
perspective". They say open questions remain about the lower bound for the confidence interval of efficacy, partly because of the case ascertainment issue, so... 8/n
...they want more data in a final report by December 2022 before considering approval. Serious adverse events seem similar to FDA's conclusions (but I haven't cross-checked case by case). Apropos today's other discussion: 7,520 people were aged 65+...9/n
...Conclusion? This is a far better report than the FDA's one on this vaccine: it's the "go to". Not comfortable that the unadjudicated person with severe Covid signals a bigger issue, but very glad the EMA is on it. 10/10

More from Government

The Government is making the same mistakes as it did in the first wave. Except with knowledge.

A thread.


The Government's strategy at the beginning of the pandemic was to 'cocoon' the vulnerable (e.g. those in care homes). This was a 'herd immunity' strategy. This interview is from


This strategy failed. It is impossible to 'cocoon' the vulnerable, as Covid is passed from younger people to older, more vulnerable people.

We can see this playing out through heatmaps. e.g. these heatmaps from the second


The Government then decided to change its strategy to 'preventing a second wave that overwhelms the NHS'. This was announced on 8 June in Parliament.

This is not the same as 'preventing a second wave'.

https://t.co/DPWiJbCKRm


The Academy of Medical Scientists published a report on 14 July 'Preparing for a Challenging Winter' commissioned by the Chief Scientific Adviser that set out what needed to be done in order to prevent a catastrophe over the winter

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Department List of UCAS-China PROFESSORs for ANSO, CSC and UCAS (fully or partial) Scholarship Acceptance
1) UCAS School of physical sciences Professor
https://t.co/9X8OheIvRw
2) UCAS School of mathematical sciences Professor

3) UCAS School of nuclear sciences and technology
https://t.co/nQH8JnewcJ
4) UCAS School of astronomy and space sciences
https://t.co/7Ikc6CuKHZ
5) UCAS School of engineering

6) Geotechnical Engineering Teaching and Research Office
https://t.co/jBCJW7UKlQ
7) Multi-scale Mechanics Teaching and Research Section
https://t.co/eqfQnX1LEQ
😎 Microgravity Science Teaching and Research

9) High temperature gas dynamics teaching and research section
https://t.co/tVIdKgTPl3
10) Department of Biomechanics and Medical Engineering
https://t.co/ubW4xhZY2R
11) Ocean Engineering Teaching and Research

12) Department of Dynamics and Advanced Manufacturing
https://t.co/42BKXEugGv
13) Refrigeration and Cryogenic Engineering Teaching and Research Office
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🌺कैसे बने गरुड़ भगवान विष्णु के वाहन और क्यों दो भागों में फटी होती है नागों की जिह्वा🌺

महर्षि कश्यप की तेरह पत्नियां थीं।लेकिन विनता व कद्रु नामक अपनी दो पत्नियों से उन्हे विशेष लगाव था।एक दिन महर्षि आनन्दभाव में बैठे थे कि तभी वे दोनों उनके समीप आकर उनके पैर दबाने लगी।


प्रसन्न होकर महर्षि कश्यप बोले,"मुझे तुम दोनों से विशेष लगाव है, इसलिए यदि तुम्हारी कोई विशेष इच्छा हो तो मुझे बताओ। मैं उसे अवश्य पूरा करूंगा ।"

कद्रू बोली,"स्वामी! मेरी इच्छा है कि मैं हज़ार पुत्रों की मां बनूंगी।"
विनता बोली,"स्वामी! मुझे केवल एक पुत्र की मां बनना है जो इतना बलवान हो की कद्रू के हज़ार पुत्रों पर भारी पड़े।"
महर्षि बोले,"शीघ्र ही मैं यज्ञ करूंगा और यज्ञ के उपरांत तुम दोनो की इच्छाएं अवश्य पूर्ण होंगी"।


महर्षि ने यज्ञ किया,विनता व कद्रू को आशीर्वाद देकर तपस्या करने चले गए। कुछ काल पश्चात कद्रू ने हज़ार अंडों से काले सर्पों को जन्म दिया व विनता ने एक अंडे से तेजस्वी बालक को जन्म दिया जिसका नाम गरूड़ रखा।जैसे जैसे समय बीता गरुड़ बलवान होता गया और कद्रू के पुत्रों पर भारी पड़ने लगा


परिणामस्वरूप दिन प्रतिदिन कद्रू व विनता के सम्बंधों में कटुता बढ़ती गयी।एकदिन जब दोनो भ्रमण कर रहीं थी तब कद्रू ने दूर खड़े सफेद घोड़े को देख कर कहा,"बता सकती हो विनता!दूर खड़ा वो घोड़ा किस रंग का है?"
विनता बोली,"सफेद रंग का"।
तो कद्रू बोली,"शर्त लगाती हो? इसकी पूँछ तो काली है"।