Grade Awarding 2021 - a thread.
1. For pupils and parents; it sounds daft but there isn’t much you can control right now. Teacher will play the main role in awarding grades, and there may well be some time or formal exam for subjects. But we don’t know exactly what yet.
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A group of Ontario experts led by SickKids has updated its guidance for school operation during the COVID-19 pandemic. The living document, COVID-19: Updated Guidance for School Operation During the Pandemic, can be read here: https://t.co/rotLqDqkQh pic.twitter.com/q7kVezAPoG
— SickKids_TheHospital (@SickKidsNews) January 21, 2021
As outlined in the tweet by @NishaOttawa yesterday, the situation is complex, and not a simple right or wrong https://t.co/DO0v3j9wzr. And no one needs to list all the potential risks and downsides of prolonged school closures.
1/It's the eve of provincial announcements on schools reopening for in-person instruction.
— Nisha Thampi (@NishaOttawa) January 20, 2021
Households are under stress and experts are divided on whether schools are unicorns or infernos.
Everyone wants to do right by kids, who have borne so much throughout this pandemic.
On the other hand: while school closures do not directly protect our most vulnerable in long-term care at all, one cannot deny that any factor potentially increasing community transmission may have an indirect effect on the risk to these institutions, and on healthcare.
The question is: to what extend do schools contribute to transmission, and how to balance this against the risk of prolonged school closures. The leaked data from yesterday shows a mixed picture -schools are neither unicorns (ie COVID free) nor infernos.
Assuming this data is largely correct -while waiting for an official publication of the data, it shows first and foremost the known high case numbers at Thorncliff, while other schools had been doing very well -are safe- reiterating the impact of socioeconomics on the COVID risk.

We used contact survey data collected by CoMix (https://t.co/ezbCIOgRa1) to quantify differences in contact patterns during November (Schools open) and January (Schools closed) 'Lockdown periods'. NOT YET PEER REVIEWED 2/
We combined this analysis with estimates of susceptibility and infectiousness of children relative to adults from literature. We also inferred relative susceptibility by fitting R estimates from CoMix to EpiForecasts estimates(https://t.co/6lUM2wK0bn). NOT YET PEER REVIEWED 3/

We estimated that reopening all schools would increase R by between 20% to 90% whereas reopening primary or secondary schools alone would increase R by 10% to 40%, depending on the infectiousness/susceptibility profile we used. NOT YET PEER REVIEWED 4/

Assuming a current R of 0.8 (in line with Govt. estimates: https://t.co/ZZhCe79zC4). Reopening all schools would increase R to between 1.0 and 1.5 and reopening either primary or secondary schools would increase R to between 0.9 and 1.2. NOT YET PEER REVIEWED 5/

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1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj

@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
