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"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."

"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."

"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."

"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."

"However, it is the active form of vitamin D, 1,25(OH)2D, that interacts specifically with the vitamin D receptor (VDR) and transacts gene expression."

"Those men with the highest compared to lowest 1,25(OH)2D and activation ratios are more likely to possess butyrate-producing bacteria that are associated with favorable gut microbial health."

"25(OH)D levels vary with site and sun exposure, but 1,25(OH)2D levels do not follow this association."

"the serum 1,25(OH)2D was the factor that explained the highest proportion of the variance in α-diversity (e.g., bacterial species diversity within an individual) at just over 5%"

"Greater α-diversity [gut bacterial species diversity] is associated with higher 1,25(OH)2D levels and larger vitamin D activation and catabolism ratios."

"Overall, apart from known correlates such as race and geographic locations, measures of vitamin D metabolic flux were remarkably associated with microbial β-diversity"

"We report robust correlations between the vitamin D metabolites, 1,25(OH)2D and 24,25(OH)2D, and the gut microbiome in 567 older men representing six geographic sites across the United States"

"Those men with higher levels of 1,25(OH)2D had greater α-diversity, even after adjusting for previously characterized determinants of microbial diversity including age, geographical origin, race, PPI, and antibiotic use."

"Serum 25(OH)D is the preferred clinical measure because it is representative of overall body stores of vit D; however, our results suggest it is the regulation of VDM, reflected by active hormone & metabolic ratios rather than body stores that have the most health implications."

"The positive association between diversity metrics and vitamin D activation and catabolism ratios suggests that physiologically normal vitamin D flux is more likely to occur in individuals with healthy microbiomes."

"In summary, we provide strong evidence of important interactions between host vitamin D signaling and the health of the gut microbiome in older men."

More from Robin Monotti FRSA ⭐

$Robin Monotti MA FRSA\u2b50$

Robin Monotti MA FRSA⭐...
@robinmonotti

"COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been

"data generated in the development & testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies)"

"be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE)."

"This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID-19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials."

"Covid-19: vaccination roll-out correlates with worse mortality trends"

Robin Monotti FRSA
@robinmonotti

I have studied the pandemic response of many countries. One of them got a key element right, which resulted in very few deaths: Japan. Their response was to keep people OUT of hospitals. A policy of early home treatment works best, hospitals only for severe cases & NO INTUBATIONS

JAPAN: "No restrictions were placed on residents’ movements, and businesses from restaurants to hairdressers stayed open. No high-tech apps that tracked people’s movements were deployed." RESULT: Among the lowest deaths in the

Saving the NHS simply means providing early treatment kits in pharmacies & avoiding hospitals for Covid19 patients. For Covid19 infections during a pandemic, hospitals are the problem, not the solution.

I have read accounts of people with high fever literally turned away from hospitals, yet being told by phone what treatment protocol to follow. That was the best pandemic response by far, NOT lockdowns.

JAPAN had some of the lowest Covid19 mortality in the world:
-NO LOCKDOWN
-NO TEST AND TRACE
-NO BUSINESS CLOSURES
-NO HOSPITAL FOR NON CRITICAL CASES
-HOME TREATMENT
-HEALTHY DIET
-LOW OBESITY

Robin Monotti
@robinmonotti

Twitter removed 800 followers from my account today. People have been writing saying twitter automatically unfollowed me for them. Follow me on Parler @robinmonotti & Telegram https://t.co/o5rFaSrCpa to bypass this.

I have already left both Facebook & Instagram. We need to keep agile.

They will try to ban Parler, blaming it for Capitol theatre. I think Telegram may survive as it's not based in the

Yes Telegram owner @durov received & accepted what effectively is an award, not a partnership: the Young Global Leaders membership of the World Economic Forum in 2017. Does this mean he passes users info on? I don't think so.

This is what @Snowden had to say about @durov. Since then Telegram introduced the option of end to end encrypted chats not saved in Telegram servers. These private chats cannot be forwarded, and none of the participants can capture screenshots of

Trust us not to turn over data. Trust us not to read your messages. Trust us not to close your channel. Maybe @Durov is an angel. I hope so! But angels have fallen before. Telegram should have been working to make channels decentralized\u2014meaning outside their control\u2014for years.
— Edward Snowden (@Snowden) December 30, 2017

Robin Monotti
@robinmonotti

The problem with meta-analysis like this is that it obfuscates the most important issue of treatment, which is timing.

#BMJResearch update: Corticosteroids probably reduce mortality and mechanical ventilation in patients with covid-19 compared with standard care, whereas azithromycin, hydroxychloroquine, interferon-beta, and tocilizumab may not reduce either https://t.co/oQ3lTWUqaz
— The BMJ (@bmj_latest) December 18, 2020

This meta-analysis of controlled trials only looks at hospitalized patients. How long were the patients ill for before being hospitalized? One week? Two? Three? Too late for zinc ionophores (HCQ) (+ZINC? No zinc no point..) to work. Severe illness becomes bacterial in nature.

Was azythromycin administered when the bacterial infections were also too advanced? I have seen Azythromycin work with my very own eyes but that's not to say that if administered too late it may not save the patient. How many patients were given AZT & ventilated? It's all timing.

All the meta-analysis is telling us is if you leave it too late you may have missed the early window for antiviral zinc treatment (Zn+HCQ) & that if you are given AZT when you are ventilated or very severe it may too late for it to save you & corticosteroids may be last resort.

And of course antibiotics need also probiotics, or they may harm the bacterial flora which is part of the immune response. Difficult to tell from a meta-analysis how this problem was managed.

$Robin Monotti FRSA \u2b50$

Robin Monotti FRSA ⭐...
@robinmonotti

Italian researchers: vaccines will not work against SARSCoV2 because this virus does not only replicate in human cells like other viruses, this one replicates through bacteria too. This is the fundamental reason why antibiotics work & vaccines will not:

Here is the Italian-EU scientific study indicating SARSCoV2 replicates in bacteria, not only human cells, and that is why antibiotics work and these vaccines will not:

"The preliminary results suggest that SARS-CoV-2 replicates in bacterial

2 of the 4 authors of the study work at the European Commission. Another works at an Italian medical research facility called Craniomed: https://t.co/EETSM3nb3T

You can find all of CRANIOMED's Carlo Brogna's published scientific research articles here, take a look:

More from Category c19

$Robin Monotti FRSA\U0001f338$

Robin Monotti FRSA🌸...
@robinmonottibis

Let's talk about MASKS!

Thread 1:

If you study the field you will see viral nebulization is a technique used to get higher infectivity of viruses. This is used with ventilator patients suffering from pseudomonas aeruginosa infections. Nebulize bacteriaphage to get deep into the lungs and kill bacteria. pic.twitter.com/82lNRMrXl4
— Kevin McKernan \U0001f642 (@Kevin_McKernan) October 24, 2020

Masks increase mortality because breathing through them nebulizes aerosols into smaller ones which bypass mucosal immunity & reach all the way into the alveoli, leading to acute respiratory distress syndrome (ARDS).

"Aerosols..within the most breathable size range between 0.5 & 5 μm, can carry SARS-CoV-2 deep to the terminal alveoli..if this transmission pathway does exist, it would bypass the mucociliary clearance & incubation period of the virus in the upper

The filtration material itself of N95's average pore size ~0.3−0.5 μm does not block finer aerosol laden with virions penetration, not to mention surgical masks.