Humanity is good, but, when we let our guard down we allow darkness to infiltrate and destroy.
Like past battles fought, we now face our greatest battle at present, a battle to save our Republic, our way of life, and what we decide (each of us) now will decide our future.

1) “Eliminationism” is a term you need not just to become familiar with, especially in today’s American rush toward authoritarianism. This will be a long, illustrated thread explaining what it means, how it works, and why Donald Trump is now our Eliminationist in Chief.

Warning: Some images contain violence and are disturbing.

Also warning: This thread is ridiculously long. 75 tweets is insane. I apologize. But this stuff is important. I hope you find it compelling anyway. If not, I understand.

2) So, what exactly do we mean by “eliminationism”? Here’s the academic definition:

3) It was largely coined by Holocaust scholar Daniel Jonah Goldhagen in his 1996 book Hitler’s Willing Executioners, about the role ordinary Germans played in the Holocaust, which he described as fueled by “eliminationist antisemitism.”

4) The book describes how in reality the largest numbers of Jews and other victims killed by Nazi directive were rounded up and gunned down or immolated en masse and buried in mass graves by ordinary Germans and non-Jewish residents of German-occupied territories.

Unless we pass laws which support people to enable them to self-isolate properly, any improvements to test & trace will have marginal impact and cases will simply spiral out of control once again as we ease lockdown in December.

A short thread on what we can do and why 👇
1/

Improving the currently poor rates of self-isolation is actually the key point, which many scientists, politicians, & commentators do still seem to be missing.

This requires good public health communication, proper support for those who need to self-isolate, & trust.
2/

Massive testing and tracing will only significantly reduce
transmission if positive cases isolate effectively. Yet
currently fewer than 20% of those who should isolate are fully adherent.

I don't think I need to explain why it's so critical to improve these rates.

3/

Survey data shows intention to adhere to test/trace/isolate behaviours is higher than self-reported adherence: whilst 76% of people intend to share contacts, only 50% of people correctly recognise symptoms &
just 12% get a test, 18% isolate, & 11% of contacts isolate properly.
4

Self-reported ability to self-isolate
is three times lower in those who earn less than £20,000 per year or have less than £100 saved.

5/

I've been wanting to write this thread for a while. It has been inspired by hearing a common thought: why can't people just "listen"? If people just followed the rules, we wouldn't be in this mess. I think this is oversimplification of the problem with COVID: 1/

It is true, there are people who haven't been following guidelines (by definition that happened a LOT at Christmas/NYE in my region), but even before, we know transmission in private gatherings happens. 2/

These private gatherings are pictured to be big raucous parties, but in reality, even before lockdown, this is just people having dinner, watching TV, doing things we did before on a daily basis. These little ripples when added across the country make a big wave.. 3/

...and little can be done about this apart from positive messaging. You can't very well have police patrolling neighbourhoods across the country. 4/

Next thing is we keep hearing over and over and over, stay home. There are diminishing returns with this advice, but also, most people who can stay home ARE. So what's the issue? There are a HUGE # of people who can't stay home because they work in essential jobs 5/

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

MY RACIST

If U remember from an earlier post I brought up Sen Elizabeth Warrens remark that "Obama did more for Wall Street than Main Street." I concur. U can ignore poor black people all day, but under no circumstance can U ever ignore poor white

Now Biden must be careful not to repeat the same mistakes of Obama. Biden most go big & go big fast. Fuck inflation. Order the treasury to start printing money. You will not beat Trump by impeaching or prosecuting him. You must beat him on the battlefield of ideas & you do so by-

helping the people he ignored. People with good jobs, food on the table & a roof over their head dont have time to do insurrections. If U help these people, you will choke off the fuel to Trumpism. Some black people will criticize me for taking this approach. My simple retort is-

you can't out-violence white people. We don't make guns. We don't make bombs. We don't make shit. You have to make it such that everyone eats. Otherwise you have to deal with the warning Heather McGhee lays out in her new book: white

Obama did not get this. He made it such that only rich white oligarchs got to feast. Everyone else got crumbs. I need you to get precisely what peace requires. There are a good number of white people in this country which would rather burn this country down than to allow any-