Seen a lot of people aver the following, "but where are the jobs?" in response to someone asserting the need to incentivize the movement of our people from agriculture to industry.
Well, here's one major part of the big answer: Labour reforms.

Thread👇

Real talk.

The right as spent years trying to paint @NancyPelosi & @HillaryClinton as extreme leftists who will take your guns, sterilize your sons, outlaw Christianity, and tax you at 80%.

Meanwhile...

The far left has tried to insist that they were both Republican-lite.

1/

Some on the far left call them war mongering neoliberal corporate owned whores.

That's on a good day, for both.

None of these charges, by either side, are remotely true of course. Not that this matters to the people putting this shit out there.

2/

The facts are these.

@HillaryClinton and @NancyPelosi have been fighting people, usually white men, for tnings their entire lives.

With little respite.

At times they have had to make impossible choices and compromises just to beo let in the door. Most women have.

3/

It must be easy to be some 26 yo white dude who has never had anyone tell him no his whole life to sit in judgement of women like them.

"How dare she..."

...do what was necessary to get a place at the table.

...do exactly what men have been doing w/o your disapproval.

4/

Let's face it, most men suck when it comes to issues that don't pertain directly to their own self interests. White men are even worse. We just are.

Most men especially suck when it comes to women's issues and I mean really suck.

How many left leaning men fell to #MeToo?

5/

1/14 How do e-cigarettes (ECs) affect cigarette smoking among youth? My new paper with @FloeFoxon simulates each scenario and finds out which one best matches actual trends... https://t.co/dBB7kcnTls @jgitchell @mikepesko @SwitchFinder @jkelovuori @TobPolicy @Clive_Bates

2/14 First, let's talk about why this question is so difficult to answer: COUNTERFACTUALS. We can't know the alternate-reality answers, like which smokers would have never started in a world without ECs, and which nonsmokers would now be smoking without ECs as an option.

3/14 So, the best we can do is use fancy/sophisticated methodologies to estimate what would have happened to youth smoking rates in the absence of ECs. In our case, simulation modeling

4/14 First, we look at the declining smoking trends *that were already happening* before ECs came (~2010), and project them into the present. This is our BASE-CASE SCENARIO about what smoking trends would be if ECs were never invented. Actual trends were LOWER than this base-case

5/14 Side note about terminology: We use the term “catalyst” instead of “gateway,” because “catalyst” is more precise about the claim we are modeling (that ECs are used first, and then causally lead to smoking). Whereas "gateway" can include other mechanisms like renormalization.

@LaurenMurphyMMA @_Miatonin @AOC There is no no differences in strength between men and women are seen when normalized for muscle cross-sectional

@_Miatonin @AOC It is reductionist (and wrong) to suggest the performance gap is all about biology (e.g. testosterone).

@_Miatonin @AOC Based on the present evidence, it is reasonable to suggest that biological, psychological, and sociocultural factors contribute to the range of gender gaps observed across sports.

@_Miatonin @AOC Men and women exhibit similar relative responses to resistance training, with no gender-specific responses noted after 10-weeks of resistance

@_Miatonin @AOC A number of other gender-‘independent’ factors contribute to the regulation of adult muscle mass, including genetics, race, adiposity, training, diet, and birth

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10