There is going to be a mental health crisis unlike anything we've seen before. PTSD will be widespread, and look who we've got running the country.
Nearly half of ICU staff in England treating people in the first corona wave experienced severe anxiety, depression, post-traumatic stress disorder or problem drinking.
— Louisa Compton (@louisa_compton) January 13, 2021
1 in 7 had thoughts of self-harming or being "better off dead" according to research from Kings College London
This is the same govt which has decimated mental health care over the past 10 years.
In 2017 the number of young people arriving in A&E with psychiatric problems had doubled since 2009 but mental health services were cut by £538million.
I'll take a stab at how much planning Johnson and his cronies have done to mitigate the onslaught of trauma-related psychological injury: none.
More from Health
1/16
Why do B12 and folate deficiencies lead to HUGE red blood cells?
And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?
For answers, we'll have to go back a few billion years.
2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.
Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine
But why does DNA contains thymine (T) instead of uracil (U)?
https://t.co/XlxT6cLLXg
3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).
In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?
https://t.co/bIZGviHBUc
4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.
DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.
https://t.co/bIZGviHBUc
5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.
When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.
[*Note: thymine is the base in dTMP]
https://t.co/AnDUtKkbZh
Why do B12 and folate deficiencies lead to HUGE red blood cells?
And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?
For answers, we'll have to go back a few billion years.

2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.
Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine
But why does DNA contains thymine (T) instead of uracil (U)?
https://t.co/XlxT6cLLXg

3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).
In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?
https://t.co/bIZGviHBUc

4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.
DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.
https://t.co/bIZGviHBUc

5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.
When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.
[*Note: thymine is the base in dTMP]
https://t.co/AnDUtKkbZh

Public Health Scholarships
This may help for those considering MS/PhD in Public Health
1. The Erasmus Mundus Joint Master Degree in Public Health in Disasters
https://t.co/1Z5qpstsSu
2. Afya Bora Global Health
3. Carl Duisberg Scholarships
https://t.co/HnNXdbWBxy
4. Commonwealth Scholarships for Developing Countries
https://t.co/3fWGf5b2OH
5. Fellowships in Public Health & Tropical
6. Fellowships to Promote Mental Health Journalism
https://t.co/MVV9PFsBJ1
7. 2021-22 Jeroen Ensink Memorial Fund
8. Paul S. Lietman Global Travel Grant for Residents & Fellows
https://t.co/qK76R495QT
9. Global Health Internships and Funding
https://t.co/FD9Gh2wXvO
10. Kofi Annan Global Health Leadership
11. MA in European Public Health
https://t.co/5x0Vr7b1j8
12. MSc in Public Health Scholarships - Maastricht University,
This may help for those considering MS/PhD in Public Health
1. The Erasmus Mundus Joint Master Degree in Public Health in Disasters
https://t.co/1Z5qpstsSu
2. Afya Bora Global Health
3. Carl Duisberg Scholarships
https://t.co/HnNXdbWBxy
4. Commonwealth Scholarships for Developing Countries
https://t.co/3fWGf5b2OH
5. Fellowships in Public Health & Tropical
6. Fellowships to Promote Mental Health Journalism
https://t.co/MVV9PFsBJ1
7. 2021-22 Jeroen Ensink Memorial Fund
8. Paul S. Lietman Global Travel Grant for Residents & Fellows
https://t.co/qK76R495QT
9. Global Health Internships and Funding
https://t.co/FD9Gh2wXvO
10. Kofi Annan Global Health Leadership
11. MA in European Public Health
https://t.co/5x0Vr7b1j8
12. MSc in Public Health Scholarships - Maastricht University,
Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13
Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13
Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13
The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13

Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13

Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13

The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13

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**Thread on Bravery of Sikhs**
(I am forced to do this due to continuous hounding of Sikh Extremists since yesterday)
Rani Jindan Kaur, wife of Maharaja Ranjit Singh had illegitimate relations with Lal Singh (PM of Ranjit Singh). Along with Lal Singh, she attacked Jammu, burnt - https://t.co/EfjAq59AyI
Hindu villages of Jasrota, caused rebellion in Jammu, attacked Kishtwar.
Ancestors of Raja Ranjit Singh, The Sansi Tribe used to give daughters as concubines to Jahangir.
The Ludhiana Political Agency (Later NW Fronties Prov) was formed by less than 4000 British soldiers who advanced from Delhi and reached Ludhiana, receiving submissions of all sikh chiefs along the way. The submission of the troops of Raja of Lahore (Ranjit Singh) at Ambala.
Dabistan a contemporary book on Sikh History tells us that Guru Hargobind broke Naina devi Idol Same source describes Guru Hargobind serving a eunuch
YarKhan. (ref was proudly shared by a sikh on twitter)
Gobind Singh followed Bahadur Shah to Deccan to fight for him.
In Zafarnama, Guru Gobind Singh states that the reason he was in conflict with the Hill Rajas was that while they were worshiping idols, while he was an idol-breaker.
And idiot Hindus place him along Maharana, Prithviraj and Shivaji as saviours of Dharma.
(I am forced to do this due to continuous hounding of Sikh Extremists since yesterday)
Rani Jindan Kaur, wife of Maharaja Ranjit Singh had illegitimate relations with Lal Singh (PM of Ranjit Singh). Along with Lal Singh, she attacked Jammu, burnt - https://t.co/EfjAq59AyI

Tomorrow again same thing happens bcoz fudus like you are creating a narrative oh Khalistan. when farmers are asking MSP. (RSS ki tatti khane wale Kerni sena ke kutte).
— Ancient Economist (@_stock_tips) December 5, 2020
U kill sikhs in 1984 just politics. To BC low IQ fudu Saale entire history was politics.
Hindu villages of Jasrota, caused rebellion in Jammu, attacked Kishtwar.
Ancestors of Raja Ranjit Singh, The Sansi Tribe used to give daughters as concubines to Jahangir.

The Ludhiana Political Agency (Later NW Fronties Prov) was formed by less than 4000 British soldiers who advanced from Delhi and reached Ludhiana, receiving submissions of all sikh chiefs along the way. The submission of the troops of Raja of Lahore (Ranjit Singh) at Ambala.
Dabistan a contemporary book on Sikh History tells us that Guru Hargobind broke Naina devi Idol Same source describes Guru Hargobind serving a eunuch
YarKhan. (ref was proudly shared by a sikh on twitter)
Gobind Singh followed Bahadur Shah to Deccan to fight for him.

In Zafarnama, Guru Gobind Singh states that the reason he was in conflict with the Hill Rajas was that while they were worshiping idols, while he was an idol-breaker.
And idiot Hindus place him along Maharana, Prithviraj and Shivaji as saviours of Dharma.
