#MedicalNicotine

348,601 "ever-#snus users had about 60% lower Parkinson's disease risk compared with never-snus users."
https://t.co/YHB9FKkUtQ

30,000 British doctors followed for 60 years: "current smokers at baseline had a 30% lower risk of

#MedicalNicotine

Nicotine is beneficial for people with #ADHD. Research on adults and adolescents with ADHD shows that nicotine patches improve focus and attention, and reduce hyperactivity & impulsivity.
https://t.co/0mTHFftmDf
#MedicalNicotine

Nicotine reduces symptoms of Alzheimer's disease (AD).
https://t.co/Tht2Y8CZiN
#MedicalNicotine

Nicotine is beneficial for people with schizophrenia. More than 70% of people with schizophrenia smoke.

#SaferNicotine alternatives could help them as therapy, and to not die from smoking.
https://t.co/lNH75kqGGM
#MedicalNicotine

Nicotine, "(either 2 mg nicotine gum or 7 mg transdermal nicotine patch) potentiates [enhances] the therapeutic properties of neuroleptics in treating Tourette's syndrome... A single patch may be effective for a variable number of days."
https://t.co/lBJztxciio
#MedicalNicotine

Nicotine promotes weight loss. It is "associated with ...increased energy expenditure as a result of increased locomotor activity, increased thermogenesis in brown adipose tissue (BAT), and alterations in fuel substrate utilization."
https://t.co/jNufO6rFdq
#MedicalNicotine

Nicotine helps smokers quit (and thus not die). Nicotine patches & gum increase smoking cessation success (5% for cold turkey; 9% for patches & gum... but many relapse by 3 years). Longer-term quit efficacy for nicotine vapes is ~20%.
https://t.co/tnNUufg80Y
#MedicalNicotine

Nicotine patch therapy may be an effective treatment in #epilepsy patients who have nAChR gene variants.
https://t.co/gGCpX96QSW
#MedicalNicotine

"Transdermal nicotine ...improves symptoms in patients with ulcerative colitis."
https://t.co/wY6PUlDqL6

"Complete resolution of symptoms was observed in 48.6% of cases with nicotine and only in 24.3% of cases with placebo."
https://t.co/iVZqgnojR0
#MedicalNicotine for #COVID19?

"Compared with never smokers, current smokers appear to be at reduced risk of SARS‐CoV‐2 infection, while former smokers appear to be at increased risk of hospitalization, disease severity and mortality from COVID‐19."
https://t.co/wuP4SZmN7m
#MedicalNicotine THREAD
👆👆👆👆👆

Nicotine has therapeutic benefits for #StopSmoking; #ParkinsonsDisease; #Alzheimers #Dementia; #ADHD; #MentalHealth; #Tourettes; #UlcerativeColitis; #Schizophrenia; #Epilepsy; #weightloss; and, possibly, preventing #coronavirus infection

More from Health

1/16
Why do B12 and folate deficiencies lead to HUGE red blood cells?

And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?

For answers, we'll have to go back a few billion years.


2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.

Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine

But why does DNA contains thymine (T) instead of uracil (U)?

https://t.co/XlxT6cLLXg


3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).

In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?

https://t.co/bIZGviHBUc


4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.

DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.

https://t.co/bIZGviHBUc


5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.

When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.

[*Note: thymine is the base in dTMP]

https://t.co/AnDUtKkbZh

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