BC HEALTH
Saved by @Alex1Powell

UK variant update:

50% more contagious and the main difference is in the rate of infection in children up to the age of 9.

No significant difference found yet in clinical course, mortality within 28 days or chance of re-infection.

1/

https://t.co/D8DXVvBeew

 50% higher infection rate

(Secondary attack rate 15.1% versus 9.8%)

2/
Main effect in children under 9 years old

(see age distributions, second image has overlay of reference onto UK variant)

3/
Essential to stop the UK variant: 50% higher transmission will lead to more cases, more hospitalizations, more ICU cases, more deaths, and greater economic costs.
Independent SAGE's plan for the UK variant

With the new Covid variant everywhere, it's not enough to just wait for the vaccine | Stephen Reicher

5/

https://t.co/cF1HPC3U2l
1)Accelerate vaccinations
2)Control: a) Advance application for travel to and from the UK, a negative PCR test prior to travel, managed isolation on arrival b) Schools should remain closed until buildings are made as safe as possible for pupils and staff
c)Universities online

6/
3) test,trace,isolate: a)Test, b)Trace contacts as quickly as possible, isolate before they can infect others. Include forward tracing (identifying who you might have infected) and backwards tracing (who infected you), c)Practical support to isolate

7/
4) Provide guidance for workplace safety.
5) Provide financial support for the public.

8/
Compare
👉higher fatality, with
👉increase in transmissibility ON fatality.

Example:
50% higher fatality increases deaths from 129 to 193.
50% higher transmissibility increases from 129 to 978 after one month, more if longer

See:
https://t.co/MYiQUL804z

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I have now read the study, and I teach critical appraisal as part of my job, so let's dive into it a bit.

@KatyMontgomerie @ElPolloDiabloX @AbigailShrier @chadfelixg First things first, the sample size in this study is tiny. 46 people. Plus, the point of comparison was "all women and men under the age of 30 in the Air Force between 2004 and 2014" rather than a longitudinal group.

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Back in January, a news story was published about Kerrianne’s study showing improved social interaction outcomes for autistic adults when paired with another autistic partner.

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Can any MP ask the government why early treatment kits to stop viral replication & infection are not made available cheaply & prescription free in pharmacies as they are in India? Is it lives we want to save or is it Big Pharma profits? Because the two are mutually exclusive.


There could even be competing kits, & the decision which to take could be left to doctors & patients, as happens with most medicines. The problem is that there is not one of these kits available cheaply & prescription free anywhere in the West.

Doxycycline, Ivermectin, Azithromycin, Hydroxychloroquine, Zinc, Vitamin D, Vitamin C, omega-3s, all approved as safe drugs decades ago. This is clearly not an issue of safety. It should be left to a doctor's experience & judgement whether they are effective or not, not academia.

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Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
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A thread based on Figure 1

A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
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Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
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Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
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The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
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This may seem bizarre - who fights against improved acceptance? - but actually has clear roots in the ongoing culture war the West seems engaged in. The identity positive autistic movement, of which I am a part, is viewed by some as another manifestation of 'wokeness'.

This is the right-wing definition of 'wokeness', of course - ie a modern equivalent of the pejorative take on political correctness, but it's definitely at the core of this 'neurorealist' movement - the idea the autistic community is being hijacked by 'woke lefties'.

They believe that the push for acceptance of neurodiversity and rejection of the medicalisation of autism is misguided and drawing attention away from those autistic people who, in their view, need more help and intervention.

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