BC HEALTH
Saved by @Alex1Powell

I am very late to this #MedicareForAll floor vote debate, but since it is still raging, I’ll join the fray by telling you a little story.

 In 2019, after I testified at the first ever #MedicareForAll hearing, I got back to Santa Barbara and realized that my own Democratic congressman was not a cosponsor of the bill! So I did some organizing.
We pulled together a ragtag coalition of some old timer health care activists, the local DSA chapter, some college students, a women’s political club, and a local elected official. We met in my living room three times to scheme.
We scheduled a meeting with our rep, @RepCarbajal. 25 of us crammed into his office even though his staff said there was only room for 8). We talked, he listened. He talked, we listened. He said he supported a strong public option. He promised to send us questions in writing.
We left, disappointed but eager to win his support. We started planning a rally. We gathered petition signatures at the farmers market and the college housing. His staff sent over 15 really detailed and good questions. We asked the National Nurses Union to help us answer them.
We sent over the answers and scheduled a second meeting. And, as we settled down, expecting a long debate, Rep. Carbajal surprised us. He would cosponsor the bill, he said! https://t.co/BM7NEdLgPM
Now, I know that it won’t always be this easy. Some representatives will require press conferences, protests, civil disobedience, and a primary challenge. Some will never sign on. But this is the work that needs to happen if we want to make real progress.
You want #MedicareForAll? Let’s build local coalitions like the Santa Barbara one in 150 districts around the country. The pieces are there. We need to get organized.
My assessment is that a floor vote would not be very helpful right now.
. @AOC is right that a floor vote is no more real or “on the record” than the cosponsor list. Especially with the Senate in Republican control. We know who is willing to publicly support us right now.
Another day of news coverage (especially of a loss) is not going to advance our agenda in a big way. We had an enormous amount of attention and debate about this during the primary.
What we need now is deep organizing to build support and hard district by district pressure for more cosponsors. Sure, a floor vote will be a good leverage point. But we aren’t ready for it right now. We haven’t done the work.
Plus, a floor vote is not nearly enough. We need structural changes to the House rules and organization that sheandothers are negotiating. We need a more democratic House, where power is distributed more widely.
But, look, this is not a foundational point. It’s tactics. It’s okay if we disagree. The Squad and @PramilaJayapal are hearing your thoughts, and they will do what they think is best. That is what we elected them to do.
But if you wanna do more than argue on Twitter, then let’s work together. Send me a DM with your name, phone number, congressional district and email address. I’ll be in touch in the new year. We’ll get our floor vote in this coming Congress. And, soon, we’ll win it.

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Nick Hinton
@NickHintonn
A Conspiracy Thread: The Sentient World Simulation


In 2007, the Department of Defense worked with researchers at Purdue University to create SEAS, or the Synthetic Environment for Analysis and Simulations. SEAS uses data from the internet to create realistically detailed models of the world which are used to predict the future.


We’re told SEAS is now capable of running real-time simulations of up to 62 nations and that it’s been used by Fortune 500 companies for strategic planning, or in other words, manipulating the market. Nevertheless, there are plans to turn SEAS into something even more advanced.


Developers say their goal is to turn SEAS into a Sentient World Simulation, or a “continuously running, continually updated mirror model of the real world.” However, some conspiracy theorists claim the SWS is already live and running inside a network of quantum computers.


Researchers like Seth Lloyd have suggested that the entire universe could be simulated inside a quantum computer. According to Geordie Rose, the co-founder of D-Wave Systems, a company that creates these machines, they can even tap into parallel worlds and other dimensions.
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Tony Breu
Tony Breu
@tony_breu
1/16
Why do B12 and folate deficiencies lead to HUGE red blood cells?

And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?

For answers, we'll have to go back a few billion years.


2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.

Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine

But why does DNA contains thymine (T) instead of uracil (U)?

https://t.co/XlxT6cLLXg


3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).

In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?

https://t.co/bIZGviHBUc


4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.

DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.

https://t.co/bIZGviHBUc


5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.

When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.

[*Note: thymine is the base in dTMP]

https://t.co/AnDUtKkbZh
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Aureliano Stingi
Aureliano Stingi
@AurelianoStingi
Controversial 3D. Probably none of you knows about Leber congenital amaurosis type 10, congenital blindness that affects 3 out of 100,000 children, condemning them to blindness for life. The only possible treatment is through gene therapy. 1/n


Thanks to Crispr-CAS9 technology we MODIFY the defective gene inside the patient eye ( they directly inject the treatment into the eye). Before CRISPR the treatment was based on Adenovirus carrying the correct form of the gene

In both cases, we MODIFY the patient DNA and that's the only way (today) to treat this disease. LCA10 is not the only genetic disease affecting kids unfortunately the list is long and the variety of diseases is terrifying.

Now think about a parent with a kid with a genetic disease, he/she would try and do anything to save him/her. ANYTHING and they would take some RISKS, gene therapy was a risk at the beginning, and any new experimental treatment shares a percentage of risk. 4/n

Now we come to #COVID19 and #vaccines. The new RNA vaccines are a HUGE scientific breakthrough, that may open new amazing therapeutic paths. And like ANY other human activity share a risk.
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matthew remski
matthew remski
@matthewremski
A staple of anti-lockdown conspiracism in yoga/wellness is that public health measures are oppressive, authoritarian, and stifling what it means to be human. Masks suppress identity and speech. Vaccines assault the sovereign body. Influencers must rise up against tyranny! /1

Ironically, pandemic management in economies where yoga/wellness is lucrative has been a neoliberal, choose-your-own-adventure mess in which centre-right governments barter with public health to enact a patchwork of half-measures that punish the poor and marginalized. /2

The goal is not universal health rights, or protecting medical systems, or saving as many lives as possible. The goal is to return to business-as-usual, using public health as a pit stop on a productivity race off a cliff. The ice caps aren’t melting fast enough, I guess. /3

Right-leaning governments, like influencers, have assessed the COVID threat with the magical bias of limitless optimism. Then they work to normalize COVID casualties as a new cost of doing business. *This* is what alt-healthers and Qamoms call “socialist”, or “communist”. /4

Centre-right governments and wellness influencers share a goal: get back to the optimism of making productivity heroic and consumption virtuous, without any reflection on structural issues of injustice, or what universal health care funding and standards would look like. /5
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Dylan Burnette
Dylan Burnette
@MAG2ART
Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
1/13
A thread based on Figure 1

A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13


Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13


Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13


The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
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